Therapeutic Advances in Cardiovascular Disease This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Pathophysiological links, echocardiographic characteristics, and clinical implications of QRS morphology in patients with dilated cardiomyopathy
Heart failure is an important clinical problem worldwide. There is great interest in evaluating the relationship between electrocardiographic variations and dilated cardiomyopathy (DCM) since it has been used as a predictor of increased morbidity and mortality. The presence of fragmentation in the QRS complexes on 12-lead electrocardiogram (ECG) was reported as a marker of depolarization abnormality in patients with DCM. Previous studies have investigated the relation between QRS morphology and DCM. QRS morphology and duration are associated with clinical deterioration and increased mortality in patients with DCM. Although...
Source: Therapeutic Advances in Cardiovascular Disease - October 9, 2015 Category: Cardiology Authors: Sunbul, M., Tigen, K. Tags: Review Source Type: research

Sesamin enhances nitric oxide bioactivity in aortas of spontaneously hypertensive rats
Conclusion: Chronic treatment with sesamin could reduce hypertension and improve endothelial dysfunction through enhancement of NO bioactivity in SHR aortas. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - October 9, 2015 Category: Cardiology Authors: Kong, X., Li, W., Guo, L.-q., Zhang, J.-x., Chen, X.-p., Liu, W.-y., Yang, J.-r. Tags: Original Research Source Type: research

Association between HbA1c levels with severity of coronary artery disease and short-term outcomes of acute ST-elevation myocardial infarction in nondiabetic patients
Conclusion: Among nondiabetic patients presenting with STEMI, the severity of CAD was higher in those with HbA1c level >5.8%; 1-year mortality and hospital readmission rates were also higher in this group of patients. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - October 9, 2015 Category: Cardiology Authors: Ghaffari, S., Niafar, F., Separham, A., Niafar, M., Pourafkari, L., Nader, N. D. Tags: Original Research Source Type: research

Regular exercise improves weight stability in patients with advanced heart failure
Conclusion: This study demonstrated that exercise is a successful adjunctive therapy to managing the daily weight variability or fluid status instability of patients with NYHA class III/IV heart failure that is often a debilitating aspect of the syndrome. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - October 9, 2015 Category: Cardiology Authors: Boyd, A. M. Tags: Original Research Source Type: research

Expression of genes of the cardiac and renal renin-angiotensin systems in preterm piglets: is this system a suitable target for therapeutic intervention?
Conclusions: Preterm cardiac and renal RAS mRNA levels were similar to term piglets, suggesting that immaturity of these RASs does not contribute to preterm cardiovascular compromise. Since preterm expression of both renal and cardiac angiotensin II-AT1R is similar to term animals, cardiovascular dysfunction in the sick preterm human neonate might be effectively treated by agents acting on their RASs. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - October 9, 2015 Category: Cardiology Authors: Kim, E., Eiby, Y., Lumbers, E., Boyce, A., Gibson, K., Lingwood, B. Tags: Original Research Source Type: research

Value of pentraxin-3 and galectin-3 in acute coronary syndrome: a short-term prospective cohort study
Conclusion: Pentraxin-3 and galectin-3 hold much promise in the ACS population as prognostic biomarkers. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - October 9, 2015 Category: Cardiology Authors: George, M., Shanmugam, E., Srivatsan, V., Vasanth, K., Ramraj, B., Rajaram, M., Jena, A., Sridhar, A., Chaudhury, M., Kaliappan, I. Tags: Original Research Source Type: research

Characterization of diastolic dysfunction heart failure following an acute hospitalization for heart failure in an urban, underserved population
Conclusion: In our population, DHF is more prevalent in younger patients of any ethnicity, especially Hispanic/Latino and black ethnicities, compared with nationwide estimates. Our patients with DHF had higher ejection fractions and were prescribed higher rates of traditional heart failure medications. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - October 9, 2015 Category: Cardiology Authors: Wobeter, B. R., Anderson, S. L., Marrs, J. C. Tags: Original Research Source Type: research

The relationship of TIMI risk index with SYNTAX and Gensini risk scores in predicting the extent and severity of coronary artery disease in patients with STEMI undergoing primary percutaneous coronary intervention
Conclusion: TRI is significantly related to SS and Gensini score in predicting the extent and severity of CAD in patients with STEMI. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - October 9, 2015 Category: Cardiology Authors: Acet, H., Ertas, F., Bilik, M. Z., Aydın, M., Yuksel, M., Polat, N., Yıldız, A., Ozyurtlu, F., Akıl, M. A., Ciftci, L., Ozbek, M., Alan, S., Toprak, N. Tags: Original Research Source Type: research

Phytochemical and in vitro and in vivo biological investigation on the antihypertensive activity of mango leaves (Mangifera indica L.)
Conclusions: Dichloromethanic fraction of M. indica presented an antihypertensive effect, most likely by ACE inhibition, with benefits in baroreflex sensitivity and cardiac hypertrophy. Altogether, the results of the present study suggest that the dichloromethanic fraction of M. indica leaves may have potential as a promoting antihypertensive agent. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - October 9, 2015 Category: Cardiology Authors: Ronchi, S. N., Brasil, G. A., do Nascimento, A. M., de Lima, E. M., Scherer, R., Costa, H. B., Romao, W., Boechat, G. A. P., Lenz, D., Fronza, M., Bissoli, N. S., Endringer, D. C., de Andrade, T. U. Tags: Original Research Source Type: research

ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension
The renin–angiotensin system (RAS) is a key component of cardiovascular physiology and homeostasis due to its influence on the regulation of electrolyte balance, blood pressure, vascular tone and cardiovascular remodeling. Deregulation of this system contributes significantly to the pathophysiology of cardiovascular and renal diseases. Numerous studies have generated new perspectives about a noncanonical and protective RAS pathway that counteracts the proliferative and hypertensive effects of the classical angiotensin-converting enzyme (ACE)/angiotensin (Ang) II/angiotensin type 1 receptor (AT1R) axis. The key compon...
Source: Therapeutic Advances in Cardiovascular Disease - September 2, 2015 Category: Cardiology Authors: Mendoza-Torres, E., Oyarzun, A., Mondaca-Ruff, D., Azocar, A., Castro, P. F., Jalil, J. E., Chiong, M., Lavandero, S., Ocaranza, M. P. Tags: Reviews Source Type: research

Angiotensin-(1-7): beyond its central effects on blood pressure
Angiotensin (Ang) (1–7) is the main component of the depressor and protective arm of the renin-angiotensin system. Ang-(1–7) induces vasodilation, natriuresis and diuresis, cardioprotection, inhibits angiogenesis and cell growth and opposes the pressor, proliferative, profibrotic, and prothrombotic actions mediated by Ang II. Centrally, Ang-(1–7) induces changes in mean arterial pressure and this effect may be linked with its inhibitory neuromodulatory action on norepinephrine neurotransmission. The present review is focused on the role of Ang-(1–7) as a protective agent in the brain. (Source: Thera...
Source: Therapeutic Advances in Cardiovascular Disease - September 2, 2015 Category: Cardiology Authors: Gironacci, M. M. Tags: Reviews Source Type: research

The compensatory renin-angiotensin system in the central regulation of arterial pressure: new avenues and new challenges
Hypertension is a widespread condition that affects millions of people around the world and has a major impact in public health. The classic renin–angiotensin system is a complex system comprised of multiple peptides and pathways that have been the driver of drug development over the years to control hypertension. However, there are still patients whose hypertension is very difficult to control with current drugs and strategies, thus motivating further research in this field. In the past two decades, important discoveries have expanded our knowledge of this system and new pathways are emerging that are helping us und...
Source: Therapeutic Advances in Cardiovascular Disease - September 2, 2015 Category: Cardiology Authors: Mendoza, A., Lazartigues, E. Tags: Reviews Source Type: research

Roles of collecting duct renin and (pro)renin receptor in hypertension: mini review
In angiotensin (Ang)-II-dependent hypertension, collecting duct renin synthesis and secretion are stimulated despite suppression of juxtaglomerular (JG) renin. This effect is mediated by Ang II type 1 (AT1) receptor independent of blood pressure. Although the regulation of JG renin is known, the mechanisms by which renin is regulated in the collecting duct are not completely understood. The presence of renin activity in the collecting duct may provide a pathway for intratubular Ang II formation since angiotensinogen substrate and angiotensin converting enzyme are present in the distal nephron. The recently named new member...
Source: Therapeutic Advances in Cardiovascular Disease - September 2, 2015 Category: Cardiology Authors: Gonzalez, A. A., Prieto, M. C. Tags: Reviews Source Type: research

Role of stimulated intrarenal angiotensinogen in hypertension
Experimental models of hypertension and patients with inappropriately increased renin formation due to a stenotic kidney, arteriosclerotic narrowing of the renal arterioles or a rare juxtaglomerular cell tumor have shown a progressive augmentation of the intrarenal/intratubular renin–angiotensin system (RAS). The increased intrarenal angiotensin II (Ang II) elicits renal vasoconstriction and enhanced tubular sodium reabsorption in proximal and distal nephron segments. The enhanced intrarenal Ang II levels are due to both increased Ang II type 1 (AT1) receptor mediated Ang II uptake and AT1 receptor dependent stimulat...
Source: Therapeutic Advances in Cardiovascular Disease - September 2, 2015 Category: Cardiology Authors: Satou, R., Shao, W., Navar, L. G. Tags: Reviews Source Type: research

Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue
Conclusions: Higher Ang-(1-12) expression and upregulation of chymase gene transcripts and enzymatic activity from the atrial appendages connected to the enlarged left versus right atrial chambers of subjects with left heart disease defines a role of this alternate Ang II forming pathway in the processes accompanying adverse atrial and ventricular remodeling. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - September 2, 2015 Category: Cardiology Authors: Nagata, S., Varagic, J., Kon, N. D., Wang, H., Groban, L., Simington, S. W., Ahmad, S., Dell'Italia, L. J., VonCannon, J. L., Deal, D., Ferrario, C. M. Tags: Original Research Source Type: research