Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue

Conclusions:
Higher Ang-(1-12) expression and upregulation of chymase gene transcripts and enzymatic activity from the atrial appendages connected to the enlarged left versus right atrial chambers of subjects with left heart disease defines a role of this alternate Ang II forming pathway in the processes accompanying adverse atrial and ventricular remodeling.

Source: Therapeutic Advances in Cardiovascular Disease - September 2, 2015 Category: Cardiology Authors: Nagata, S., Varagic, J., Kon, N. D., Wang, H., Groban, L., Simington, S. W., Ahmad, S., Dell'Italia, L. J., VonCannon, J. L., Deal, D., Ferrario, C. M. Tags: Original Research Source Type: research