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Statin therapy and the risk for diabetes among adult women: do the benefits outweigh the risk?
Purpose of review: The purpose of this review was to examine statin therapy and the risk for diabetes among adult women using a selective review. Recent findings: The literature contains reports of new-onset diabetes associated with statin use. While many studies do not report sex-specific results, there is evidence indicating the risk to benefit ratio may vary by gender. However, the absolute effects are not clear because women have historically been under-represented in clinical trials. Summary: A review of the literature indicates that the cardiovascular benefits of statins appear to outweigh the risk for statin-relat...
Source: Therapeutic Advances in Cardiovascular Disease - February 7, 2013 Category: Cardiology Authors: Ma, Y., Culver, A., Rossouw, J., Olendzki, B., Merriam, P., Lian, B., Ockene, I. Tags: Review Source Type: research

Clinical and economic outcomes associated with amlodipine/renin-angiotensin system blocker combinations
Conclusion: The results suggested that treatment with FDC AML/OM was associated with greater likelihood of adherence and lower overall costs than with FDC AML/BEN and LDC AML/ARB, and lower risk of cardiovascular event composite versus LDC AML/ARB. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - February 7, 2013 Category: Cardiology Authors: Ferrario, C. M., Panjabi, S., Buzinec, P., Swindle, J. P. Tags: Original Research Source Type: research

The new patent foramen ovale occluder FIGULLA in complex septal anatomy: a case series
Conclusion: FSO shows high performance in patients with PFO and complex septal anatomy when compared with patients with PFO and uncomplicated atrial anatomy treated by ASO. Its favorable behavior is probably related to fabric features such as the total amount of metal and the presence of titanium. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - February 7, 2013 Category: Cardiology Authors: Baglini, R., Baldari, D., Amaducci, A., D'Ancona, G. Tags: Original Research Source Type: research

Angiotensin II receptor blockade and insulin sensitivity in overweight and obese adults with elevated blood pressure
We tested the hypothesis that olmesartan, an angiotensin II receptor blocker (ARB) devoid of peroxisome proliferator-activated receptor agonist activity, would improve whole-body insulin sensitivity in overweight and obese individuals with elevated blood pressure (BP). Sixteen individuals (8 women, 8 men; age=49.5 ± 2.9 years; body mass index=33.0 ± 1.7 kg/m2) were randomly assigned in a crossover manner to control and ARB interventions. Insulin sensitivity was determined from intravenous glucose tolerances tests before and after each 8-week intervention. BP, body weight, body fat, lipid and lipoprotein conc...
Source: Therapeutic Advances in Cardiovascular Disease - February 7, 2013 Category: Cardiology Authors: Marinik, E. L., Frisard, M. I., Hulver, M. W., Davy, B. M., Rivero, J. M., Savla, J. S., Davy, K. P. Tags: Original Research Source Type: research

Comparing the safety of ticagrelor versus clopidogrel: insights from the FDA reports
(Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - February 7, 2013 Category: Cardiology Authors: DiNicolantonio, J. J., Serebruany, V. L. Tags: Editorial Source Type: research

Angiotensin II receptor blockade and insulin sensitivity in overweight and obese adults with elevated blood pressure
Elaina L. Marinik, Madlyn I. Frisard, Matthew W. Hulver, Brenda M. Davy, Jose M. Rivero, Jyoti S. Savla, Kevin P. DavyFeb 1, 2013; 7:11-20Original Research (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - February 1, 2013 Category: Cardiology Authors: Elaina L. Marinik, Madlyn I. Frisard, Matthew W. Hulver, Brenda M. Davy, Jose M. Rivero, Jyoti S. Savla, Kevin P. Davy Tags: Original Research Source Type: research

Statin therapy and the risk for diabetes among adult women: do the benefits outweigh the risk?
Yunsheng Ma, Annie Culver, Jacques Rossouw, Barbara Olendzki, Philip Merriam, Bill Lian, Ira OckeneFeb 1, 2013; 7:41-44Review (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - February 1, 2013 Category: Cardiology Authors: Yunsheng Ma, Annie Culver, Jacques Rossouw, Barbara Olendzki, Philip Merriam, Bill Lian, Ira Ockene Tags: Review Source Type: research

Altered regional blood flow distribution in Mas-deficient mice
Giancarla Aparecida Botelho-Santos, Michael Bader, Nathalia Alenina, Robson Augusto Souza SantosOct 1, 2012; 6:201-211Original Research (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - October 1, 2012 Category: Cardiology Authors: Giancarla Aparecida Botelho-Santos, Michael Bader, Nathalia Alenina, Robson Augusto Souza Santos Tags: Original Research Source Type: research

Safety and efficacy of intracoronary adenosine administration in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: a meta-analysis of randomized controlled trials
Mukesh Singh, Tejaskumar Shah, Kavia Khosla, Param Singh, Janos Molnar, Sandeep Khosla, Rohit AroraJun 1, 2012; 6:101-114Original Research (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - June 1, 2012 Category: Cardiology Authors: Mukesh Singh, Tejaskumar Shah, Kavia Khosla, Param Singh, Janos Molnar, Sandeep Khosla, Rohit Arora Tags: Original Research Source Type: research

What is the evidence for IABP in STEMI with and without cardiogenic shock?
Suzanne de Waha, Steffen Desch, Ingo Eitel, Georg Fuernau, Philipp Lurz, Antoinette de Waha, Gerhard Schuler, Holger ThieleJun 1, 2012; 6:123-132Review (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - May 31, 2012 Category: Cardiology Authors: Suzanne de Waha, Steffen Desch, Ingo Eitel, Georg Fuernau, Philipp Lurz, Antoinette de Waha, Gerhard Schuler, Holger Thiele Tags: Review Source Type: research

Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats
Norihito Moniwa, Jasmina Varagic, Sarfaraz Ahmad, Jessica L. VonCannon, Carlos M. FerrarioFeb 1, 2012; 6:15-29Original Research (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - February 1, 2012 Category: Cardiology Authors: Norihito Moniwa, Jasmina Varagic, Sarfaraz Ahmad, Jessica L. VonCannon, Carlos M. Ferrario Tags: Original Research Source Type: research