Therapeutic Advances in Cardiovascular Disease This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Systemic light-chain amyloidosis presenting with rapid progressive heart failure
We present here a case of AL amyloidosis with presenting rapid progressive heart failure. Despite improvements in diagnostic and therapeutic modalities, diagnosis is difficult and prognosis is still poor in patients with cardiac involvement as in the present case. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - July 18, 2013 Category: Cardiology Authors: Sunbul, M., Durmus, E., Kivrak, T., Besiroglu, F., Gerin, F., Sari, I., Mutlu, B. Tags: Letter to the Editor Source Type: research

Unprotected left main coronary stenting as alternative therapy to coronary bypass surgery in high surgical risk acute coronary syndrome patients
Acute coronary syndrome has a high mortality rate that dramatically increases in the presence of left main coronary artery (LMCA) disease. Over the past decades, coronary artery bypass graft (CABG) surgery has been commonly accepted as the standard of care for patients with LMCA stenosis and is still considered the first-line treatment in current practice guidelines. Percutaneous coronary intervention (PCI) of protected and unprotected LMCA has gained popularity and is increasingly utilized with comparable outcomes to CABG in randomized controlled trials. In-stent restenosis and the need for revascularization provide the m...
Source: Therapeutic Advances in Cardiovascular Disease - July 18, 2013 Category: Cardiology Authors: Abdelmalak, H. D., Omar, H. R., Mangar, D., Camporesi, E. M. Tags: Reviews Source Type: research

Update on platelet glycoprotein IIb/IIIa inhibitors: recommendations for clinical practice
Antiplatelet therapy is the cornerstone of treatment for patients with acute coronary syndrome (ACS) and undergoing percutaneous coronary intervention (PCI). Glycoprotein IIb/IIIa receptors mediate platelet aggregation, representing the final common pathway of platelet-mediated thrombosis. Therefore, agents blocking this pathway may be desirable for the treatment of patients with ACS and PCI. Glycoprotein IIb/IIIa receptor inhibitors have been widely investigated and have been key to the pharmacological advancements in the field. However, although GPIs have been important to reduce ischemic complications, their elevated ri...
Source: Therapeutic Advances in Cardiovascular Disease - July 18, 2013 Category: Cardiology Authors: Muniz-Lozano, A., Rollini, F., Franchi, F., Angiolillo, D. J. Tags: Reviews Source Type: research

Use of aliskiren in Latin America in a real-world setting: Aliskiren in Latin America Study (ALAS)
Conclusion: The BP reduction levels and the low adverse event rate demonstrate the adequate efficacy and safety profile of aliskiren (alone or with hydrochlorothiazide). (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - July 18, 2013 Category: Cardiology Authors: Volman, S., Benitez, F. N., Cedenio, H., Giorgi, M., Jaramillo, N., Molina, N., Zilberman, J. Tags: Original Research Source Type: research

Reducing residual risk: modern pharmacochemistry meets old-fashioned lifestyle and adherence improvement
Despite remarkable advances in identifying and managing coronary heart disease, the global burden of cardiovascular (CV) risk and levels of undetected, subclinical heart disease remain enormous. Substantial numbers of patients do not reach their therapeutic goals, others are unable to tolerate the treatments, half may fail to adhere to their programs, and in those who do attain their targets, major cardiovascular events may continue. Well-known risk factors, such as obesity and diabetes, have now gained the upper hand, with no evidence-based remedy capable of reversing this trend. All told, less than 1% of American adults ...
Source: Therapeutic Advances in Cardiovascular Disease - May 20, 2013 Category: Cardiology Authors: Kones, R. Tags: Reviews Source Type: research

Direct renin inhibition: extricating facts from facades
The renin–angiotensin system (RAS) affects vascular tone, cardiac output and kidney function. By these means the RAS plays a key role in the pathogenesis of arterial hypertension. As a result, RAS inhibition is highly effective not only in lowering blood pressure but also in reducing kidney disease progression (particularly when associated with proteinuria) and cardiovascular events. Among RAS blocking agents, direct renin inhibitors have shown not only excellent efficacy in hypertension control but also pharmacologic tolerance that is comparable with other renin–angiotensin suppressors. Indeed, aliskiren, the ...
Source: Therapeutic Advances in Cardiovascular Disease - May 20, 2013 Category: Cardiology Authors: Juncos, L. Tags: Reviews Source Type: research

Management of pulmonary hypertension in left heart disease
Pulmonary hypertension (PH) due to left heart disease is classified as group II according to the Dana Point classification, which includes left ventricular systolic and/or diastolic left heart failure, and left-sided valvular disease. PH due to left heart disease is the most common cause and when present, especially with right ventricular dysfunction, is associated with a worse prognosis. Left heart disease with secondary PH is associated with increased left atrial pressure, which causes a passive increase in pulmonary pressure. Passive PH could be superimposed by an active protective, and in some patients by an ‘out...
Source: Therapeutic Advances in Cardiovascular Disease - May 20, 2013 Category: Cardiology Authors: Schmeisser, A., Schroetter, H., Braun-Dulleaus, R. C. Tags: Reviews Source Type: research

A heat and moisture mask attenuates cardiovascular stress during cold air exposure
Conclusion: Subgroup analyses suggested that the effect of the HME in mitigating systolic blood pressure increase from inhalation of cold air was significantly greater for patients aged 60 years or over than for those under 60 years. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - May 20, 2013 Category: Cardiology Authors: Seifert, J., McNair, M., DeClercq, P., St Cyr, J. Tags: Original Research Source Type: research

Twenty-year route of prevalence of risk factors, treatment patterns, complications, and mortality rate of acute myocardial infarction in Iran
Conclusion: The results indicate prominent improvement in the management process of patients suffering from acute myocardial infarction within the past 20 years. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - May 20, 2013 Category: Cardiology Authors: Ghaffari, S., Hakim, H., Pourafkari, L., Asl, E. S., Goldust, M. Tags: Original Research Source Type: research

Exercise testing in hypertensive patients for assessing the cardiovascular protective potential of antihypertensive drugs
Exercise testing is an established noninvasive tool in cardiology used to diagnose and guide treatment in individuals with suspected or confirmed coronary artery disease. Owing to the wealth of information it provides, exercise testing is also being utilized to evaluate prehypertensive stages, characterize hypertension, assess tolerance to exercise and the efficacy of antihypertensive therapies, and predict target organ damage and cardiovascular risk. The literature on exercise tolerance tests is relatively limited since these studies are difficult to conduct although they represent a valuable test for evaluating the benef...
Source: Therapeutic Advances in Cardiovascular Disease - April 12, 2013 Category: Cardiology Authors: Brunel, P., Baschiera, F., Cifkova, R. Tags: Reviews Source Type: research

Chemotherapy-related cardiotoxicity
Cardiovascular toxicity caused by cancer therapy is a challenging area which needs thorough evaluation and research. Numerous studies, meta-analyses and reviews have been published in the past discussing cardiotoxicity caused by chemotherapeutic agents. A brief review of the on-target and off-target cardiotoxicities caused by chemotherapeutic agents is presented here. Cardiotoxicities are broadly outlined in terms of left ventricular dysfunction, hypertension and thromboembolic events. The mechanisms leading to the cardiotoxicity profiles of various chemotherapeutic agents are discussed. The management of various cardiotox...
Source: Therapeutic Advances in Cardiovascular Disease - April 12, 2013 Category: Cardiology Authors: Aggarwal, S., Kamboj, J., Arora, R. Tags: Reviews Source Type: research

Testosterone reduces vascular relaxation by altering cyclic adenosine monophosphate pathway and potassium channel activation in male Sprague Dawley rats fed a high-salt diet
Conclusion: Inhibition of potassium channel or adenylyl cyclase activation appears to contribute to the mechanisms by which a high-salt diet increases vascular tone. These effects were counteracted by orchidectomy in male Sprague Dawley rats. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - April 12, 2013 Category: Cardiology Authors: Oloyo, A. K., Sofola, O. A., Anigbogu, C. N., Nair, R. R., Vijayakumar, H. S., Fernandez, A. C. Tags: Original Research Source Type: research

Effect of acute exercise on cardiovascular hemodynamic and red blood cell concentrations of purine nucleotides in hypertensive compared with normotensives rats
Conclusion: SHRs were more tolerant to increases in HR and SBP induced by exercise, and have more profound postexercise hemodynamic effects than SDRs. The hemodynamic effects were linked closely with RBC concentrations of ATP and GTP in both SDRs and SHRs. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - April 12, 2013 Category: Cardiology Authors: Yeung, P. K. F., Dauphinee, J., Marcoux, T. Tags: Original Research Source Type: research

Burden of comorbidities among patients with atrial fibrillation
Conclusions: The health burden carried by patients often extends far beyond atrial fibrillation. Physicians should carefully consider comorbidities and concomitant medications when managing patients with atrial fibrillation. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - April 12, 2013 Category: Cardiology Authors: LaMori, J. C., Mody, S. H., Gross, H. J., daCosta DiBonaventura, M., Patel, A. A., Schein, J. R., Nelson, W. W. Tags: Original Research Source Type: research

Prognostic value of cardiac troponin levels in infective endocarditis
(Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - February 7, 2013 Category: Cardiology Authors: Burton, M. J., Cockrell, J., Holguin, G., Geraci, S. Tags: Letter to the Editor Source Type: research