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D-Ribose aids heart failure patients with preserved ejection fraction and diastolic dysfunction: a pilot study
Conclusions: This pilot study revealed some beneficial trends with D-ribose even with this small cohort size. However, future investigations are necessary to further substantiate these observed benefits. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - May 19, 2015 Category: Cardiology Authors: Bayram, M., St. Cyr, J. A., Abraham, W. T. Tags: Original Research Source Type: research

Angiotensin II receptor blockade and skeletal muscle metabolism in overweight and obese adults with elevated blood pressure
Conclusions: Treatment with olmesartan for 8 weeks does not improve fatty acid oxidation or the activity of enzymes associated with oxidative metabolism in skeletal muscle from overweight and obese individuals. Taken together, our results indicate that improvements in skeletal muscle metabolism are not among the additional benefits of olmesartan that extend beyond blood pressure reduction. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - March 3, 2015 Category: Cardiology Authors: Boutagy, N. E., Marinik, E. L., McMillan, R. P., Anderson, A. S., Frisard, M. I., Davy, B. M., Rivero, J. M., Davy, K. P., Hulver, M. W. Tags: Original Research Source Type: research

Chronic aortic root pressure-loading assessment model
Conclusions: This animal model allowed successful serial pressure-load sensing assessment of the aortic root/annular areas, providing a better physiological understanding of these anatomical inter-relationships. This added information could aid in future device designs with potential improved clinical outcomes. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - March 3, 2015 Category: Cardiology Authors: Rakow, N., Barka, N., Gerhart, R., Grassl, E., Green, M., Rothstein, P., Schu, C., Kopcak, M., Shecterle, L. M., St.Cyr, J. A. Tags: Original Research Source Type: research

Outcome of prolonged QRS interval in dilated cardiomyopathy: role of implantable cardioverter-defibrillators on mortality
Conclusions: Prolonged QRS interval is significantly associated with a higher rate of mortality. However, we believe that cardiac pacing with an ICD in such patients can significantly improve outcomes. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - March 3, 2015 Category: Cardiology Authors: Shuaib, W., Shahid, H., Khan, M. S., Alweis, R., Sanchez, L. R. Tags: Original Research Source Type: research

Perspective The failure of cholesteryl ester transfer protein inhibitors: is it due to increased blood viscosity?
(Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - March 3, 2015 Category: Cardiology Authors: Sloop, G. D., Weidman, J. J., St.Cyr, J. A. Tags: Editorial Source Type: research

The role of chronic hyperviscosity in vascular disease
Gregory Sloop, Ralph E. Holsworth Jr, Joseph J. Weidman, John A. St CyrFeb 1, 2015; 9:19-25Review (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - February 1, 2015 Category: Cardiology Authors: Gregory Sloop, Ralph E. Holsworth Jr, Joseph J. Weidman, John A. St Cyr Tags: Review Source Type: research

The role of chronic hyperviscosity in vascular disease
The pathogenesis of several major cardiovascular diseases, including atherosclerosis, hypertension, and the metabolic syndrome, is not widely understood because the role of blood viscosity is overlooked. Low-density lipoprotein accelerates atherosclerosis by increasing blood viscosity in areas of low flow or shear, predisposing to thrombosis. Atherosclerotic plaques are organized mural thrombi, as proposed by Duguid in the mid-twentieth century. High-density lipoprotein protects against atherosclerosis by decreasing blood viscosity in those areas. Blood viscosity, at the least, contributes to hypertension by increasing sys...
Source: Therapeutic Advances in Cardiovascular Disease - January 13, 2015 Category: Cardiology Authors: Sloop, G., Holsworth, R. E., Weidman, J. J., St Cyr, J. A. Tags: Review Source Type: research

Antihypertensive effectiveness of combination therapy with losartan/hydrochlorothiazide for 'real world' management of isolated systolic hypertension
Conclusions: Lo/HTCZ is safe and effective in reducing and improving BP control in a ‘real world’ setting. Treatment with Lo/HTCZ enabled a substantial proportion of hypertensive patients with associated diseases to achieve the recommended goal of <140 mm Hg. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - January 13, 2015 Category: Cardiology Authors: Suzuki, H., Shimada, K., Fujiwara, K. Tags: Original Research Source Type: research

Oral verapamil in paroxysmal supraventricular tachycardia recurrence control: a randomized clinical trial
Conclusion: Oral verapamil can decrease paroxysmal supraventricular tachycardia recurrence after successful control with intravenous adenosine. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - January 13, 2015 Category: Cardiology Authors: Shaker, H., Jahanian, F., Fathi, M., Zare, M. Tags: Original Research Source Type: research

A rare cause of cardiogenic shock: variant angina
Variant angina (VA) is a clinical syndrome caused by spontaneous vasospasm of the epicardial coronary artery which is characterized by episodes of angina. Endothelial dysfunction and neurohormonal hyperactivity are important factors in pathogenesis of VA. Although patient prognosis is good, VA may be one of the reasons of sudden cardiac death (SCD) in case of persistent ST segment elevation and malignant arrhythmias. Therefore, early treatment of VA is crucial for prevention of malignant arrhythmias and SCD. In this case report we describe a case of VA presented with cardiogenic shock and malignant ventricular arrhythmia. ...
Source: Therapeutic Advances in Cardiovascular Disease - November 11, 2014 Category: Cardiology Authors: Akhundova, A., Sunbul, M., Bozbay, M., Paudel, A., Yesildag, O. Tags: Letter to the Editor Source Type: research

A review of anomalous origination of a coronary artery from an opposite sinus of Valsalva (ACAOS) impact on major adverse cardiovascular events based on coronary computerized tomography angiography: a 6-year single center review
Conclusion: ACAOS continues to be a rare but presumed fatal condition in subsets identified to carry high risk features. As the characteristics of the anomalous vessels that increase risk are still debated, over an intermediate to long follow up in a single large center, none of the different anomalous findings with varying degrees of high risk findings were associated with sudden death. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - November 11, 2014 Category: Cardiology Authors: Clark, R. A., Marler, A. T., Lin, C. K., McDonough, R. J., Prentice, R. L., Malik, J. A., Villines, T. C., Hulten, E. A., Thomas, D. M., Slim, A. M. Tags: Original Research Source Type: research

Adiponectin expression and the cardioprotective role of the vitamin D receptor activator paricalcitol and the angiotensin converting enzyme inhibitor enalapril in ApoE-deficient mice
Conclusion: Together, our data presented a novel role for VDRA and ACEI in reducing factors associated with CHD that may lead to the discovery of new therapeutic venues. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - November 11, 2014 Category: Cardiology Authors: Suarez-Martinez, E., Husain, K., Ferder, L. Tags: Original Research Source Type: research

Current state of endothelin receptor antagonism in hypertension and pulmonary hypertension
Endothelin 1 (ET-1), a potent vasoconstrictive substance, was discovered in 1988 by Yanagisawa and colleagues, and since then, a quarter of a century has passed. Understanding the biology of ET-1 has rapidly developed by characterizing the components of its receptors and processing enzymes. Numerous studies have revealed not only physiological but also various pathophysiological roles of the ET system. At first, ET-1 was the attractive and promising target for the treatment of hypertension owing to its potent vasoconstrictive nature and a variety of ET receptor antagonists (ERAs) were studied. However, the clinical applica...
Source: Therapeutic Advances in Cardiovascular Disease - August 19, 2014 Category: Cardiology Authors: Miyagawa, K., Emoto, N. Tags: Reviews Source Type: research

Rare infection of implantable cardioverter-defibrillator lead with Candida albicans: case report and literature review
Infection of implanted cardiac devices has a low rate of occurrence. Fungal infections of such devices represent an atypical phenomenon, associated with high mortality. Both medical and surgical therapies are recommended for a successful outcome. A 60-year-old woman with past medical history of heart failure with reduced ejection fraction, implantable cardioverter-defibrillator (ICD) placement, sarcoidosis and diabetes presented with fevers and atypical pleuritic chest pain. Transthoracic echocardiogram revealed a highly mobile 2.09 cm by 4.49 cm mass associated with the ICD wire. Blood cultures were positive for Candida a...
Source: Therapeutic Advances in Cardiovascular Disease - August 19, 2014 Category: Cardiology Authors: Rivera, N. T., Bray, N., Wang, H., Zelnick, K., Osman, A., Vicuna, R. Tags: Reviews Source Type: research