Combination therapy of vitamin C and phenolics-rich fraction of Khaya senegalensis stem bark extract against Trypanosoma brucei brucei infection
Publication date: Available online 28 April 2017 Source:Synergy Author(s): Mohammed Auwal Ibrahim, Aliyu Muhammad Musa, Hassanat Taye Tairu, Maryam Kassim, Abubakar Babando Aliyu, Nasir Tajuddeen, Hadiza Lawal Abdullahi, Nathan Habila The phenolics-rich fraction of Khaya senegalensis A. Juss (Meliaceae) stem bark extract (pfks) has been previously reported to possess potent antitrypanosomal activity at 300mg/kg body weight (bw) but could not completely prevent disease-induced anemia and organ damage in addition to being slightly hepatotoxic at the same dose. Therefore, the effects of a combined administration of ...
Source: Synergy - April 29, 2017 Category: Molecular Biology Source Type: research
Synergistic interactions of chamomile flower, myrrh and coffee charcoal in inhibiting pro-inflammatory chemokine release from activated human macrophages
Conclusion Synergistic effects between all plant components contribute to the anti-inflammatory activity of all dual combinations of the plant components and support the composition of the herbal combination. Graphical abstract (Source: Synergy)
Source: Synergy - April 21, 2017 Category: Molecular Biology Source Type: research
Synergistic interactions of chamomile flower; myrrh and coffee charcoal in inhibiting pro-inflammatory chemokine release from activated human macrophages
Conclusion Synergistic effects between all plant components contribute to the anti-inflammatory activity of all dual combinations of the plant components and support the composition of the herbal combination. Graphical abstract (Source: Synergy)
Source: Synergy - March 23, 2017 Category: Molecular Biology Source Type: research
Synergistic effects —Is it possible to make ‘the devil an angel’?
Publication date: June 2017 Source:Synergy, Volume 4 Author(s): H.G Schweim At the conclusion of all drug research is the ‘approval of the (new) drug’. Therefore, for scientists, it’s unavoidable to think about the process of regulation. First, keep in mind that all regulators are (very) conservative. All regulators have learned the lesson: avoid pharmacovigilance cases. Don’t take risks; it will infringe on your career. Non-approval is the best way to avoid failures. To be frank, there were and are several unacceptable combinations on the market. If new ideas like ‘synergy’ come up, ‘slow motion’ is the...
Source: Synergy - January 6, 2017 Category: Molecular Biology Source Type: research
Herb –drug interaction potential of Berberis aristata through cytochrome P450 inhibition assay
Publication date: June 2017 Source:Synergy, Volume 4 Author(s): Shiv Bahadur, Pulok K. Mukherjee, Subrata Pandit, S.K. Milan Ahmmed, Amit Kar Herbal medicines have been used from ancient times for the management of several disease and ailments along with prescribed medicine without consulting the physicians. Berberis aristata DC. has been widely used in management of diabetes as alternative therapy in India and other Asian countries. An approach has been made to evaluate the possible cytochrome P450 (CYP450) enzyme inhibition potential with the bark of the anti-diabetic herb Berberis aristata DC. along with combinat...
Source: Synergy - December 30, 2016 Category: Molecular Biology Source Type: research
Synergistic effects – is it possible to make ‘the devil an angel’?
Publication date: Available online 23 December 2016 Source:Synergy Author(s): H.G Schweim At the conclusion of all drug research is the ‘approval of the (new) drug’. Therefore, for scientists, it’s unavoidable to think about the process of regulation. First, keep in mind that all regulators are (very) conservative. All regulators have learned the lesson: avoid pharmacovigilance cases. Don’t take risks; it will infringe on your career. Non-approval is the best way to avoid failures. To be frank, there were and are several unacceptable combinations on the market. If new ideas like ‘synergy’ come up, ‘slow mo...
Source: Synergy - December 23, 2016 Category: Molecular Biology Source Type: research
Statement to the future of combination medicinal products [1]
Publication date: December 2016 Source:Synergy, Volume 3, Issue 4 Author(s): Harald G. Schweim (Source: Synergy)
Source: Synergy - December 7, 2016 Category: Molecular Biology Source Type: research
Herb-drug interaction potential of Berberis aristata through cytochrome P450 inhibition assay
Publication date: Available online 7 December 2016 Source:Synergy Author(s): Shiv Bahadur, Pulok K Mukherjee, Subrata Pandit, SKMilan Ahmmed, Amit Kar Herbal medicines have been used from ancient times for the management of several disease and ailments along with prescribed medicine without consulting the physicians. Berberis aristata DC. has been widely used in management of diabetes as alternative therapy in India and other Asian countries. An approach has been made to evaluate the possible cytochrome P450 (CYP450) enzyme inhibition potential with the bark of the anti-diabetic herb Berberis aristata DC. along with...
Source: Synergy - December 6, 2016 Category: Molecular Biology Source Type: research
Statement to the future of combination medicinal products1
Publication date: Available online 5 December 2016 Source:Synergy Author(s): Harald G. Schweim (Source: Synergy)
Source: Synergy - December 4, 2016 Category: Molecular Biology Source Type: research
Combination screening of synthetic drugs and plant derived natural products —Potential and challenges for drug development
Publication date: September 2014 Source:Synergy, Volume 1, Issue 1 Author(s): Gudrun Sigrid Ulrich-Merzenich Plants are a precious source for medicine and drug development. An estimated one third of our present medicines are derived from natural sources – either directly isolated, synthesized or semi-synthesized by structural modification of their natural compounds. Well known examples are colchicine, morphine, semi-synthetic aspirin, taxol or penicillin. However, drug development from natural sources as well as by synthesis is presently facing a set back. Most new drugs fail in the step from the preclinic to the c...
Source: Synergy - July 20, 2016 Category: Molecular Biology Source Type: research
Adenosine receptors: Intermembrane receptor –receptor interactions in the brain
Publication date: December 2014 Source:Synergy, Volume 1, Issue 2 Author(s): Karen Nieber, Sebastian Michael In the vertebrate central nervous system (CNS) the modulation of synaptic transmission by metabotropic or ionotropic receptors is an important source of control and dynamical adjustment in synaptic activity and can contribute to synergistic or antagonistic effects. Adenosine is released from most cells, including Sneurons and glial cells. Once in the extracellular space, adenosine modifies cell functioning by operating G-protein-coupled receptors. In general, adenosine has been found to act in concert with o...
Source: Synergy - July 20, 2016 Category: Molecular Biology Source Type: research
Drug combination in vivo using combination index method: Taxotere and T607 against colon carcinoma HCT-116 xenograft tumor in nude mice
Publication date: Available online 30 June 2016 Source:Synergy Author(s): Jianing Fu, Ning Zhang, Joseph H. Chou, Hua-Jin Dong, Shu-Fu Lin, Gudrun S. Ulrich-Merzenich, Ting-Chao Chou The median-effect equation (MEE) of the mass-action law and the combination index (CI) theorem have been used for quantitative determination of synergism (CI <1), antagonism (CI >1) and additive effect (CI=1) in animals in vivo. Experimental design, the theoretical algorithm and the CompuSyn software simulation have been used to illustrate step-by-step for the combination of two anti-cancer agents, Taxotere and ...
Source: Synergy - June 30, 2016 Category: Molecular Biology Source Type: research
Screening of Synergistic Interactions of Epigallocatechin-3-gallate with Antiangiogenic and Antitumor Compounds
Conclusion Combinations of EGCG and 4-methylumbelliferone synergistically decrease endothelial and tumor cell survival. In contrast, the presence of EGCG antagonizes with the antiproliferative effect exerted by vitamin D3 on endothelial and tumor cells. Graphical abstract (Source: Synergy)
Source: Synergy - June 29, 2016 Category: Molecular Biology Source Type: research
Modelling synergistic effects of appetite regulating hormones
Publication date: Available online 23 December 2015 Source:Synergy Author(s): Julie B. Schmidt, Christian Ritz We briefly reviewed one definition of dose addition, which is applicable within the framework of generalized linear models. We established how this definition of dose addition corresponds to effect addition in case only two doses per compound are considered for evaluating synergistic effects. The link between definitions was exemplified for an appetite study where two appetite hormones were studied. Graphical abstract Highlights (Source: Synergy)
Source: Synergy - December 25, 2015 Category: Molecular Biology Source Type: research
To investigate the pharmacokinetic profile of ellagic acid in presence of Aloe Vera gel powder in rabbits using validated HPLC method
Publication date: Available online 22 November 2015 Source:Synergy Author(s): A.N. Ranade, N.S. Ranpise, C. Ramesh The purpose of this study was to evaluate the pharmacokinetic parameters of ellagic acid in rabbits. A bilayer floating tablet of ellagic acid and Aloe vera gel powder was prepared to treat Helicobacter pylori induced gastric ulcers. There was a need to assess the effect of Aloe vera on the pharmacokinetic parameters of ellagic acid. For this purpose comparison was done between standard ellagic acid formulation and bilayer floating tablet using a validated HPLC method. The method developed was found ...
Source: Synergy - November 22, 2015 Category: Molecular Biology Source Type: research
