Challenges in the investigation of combinatory modes of action of nutrients and pharmaceuticals
Publication date: Available online 9 October 2018Source: SynergyAuthor(s): Alexander N. Shikov, Olga N. Pozharitskaya, Valery G. MakarovAbstractRecent publication evidenced about rationality and efficacy of combinatory therapy of antibiotic resistance, diabetes, obesity, cancer, viral infections, inflammatory bowel disease, etc. The combination of nutrients and pharmaceuticals has a good chance of contributing to a modern strategy of multi-target drug discovery. Different approaches and methods for the investigation of combinatory modes of action can be roughly classified into: in vitro, in vivo, in silico and in clinic. T...
Source: Synergy - October 10, 2018 Category: Molecular Biology Source Type: research
Synergy assessments of plant extracts used in the treatment of stress and aging-related disorders
Publication date: Available online 9 October 2018Source: SynergyAuthor(s): Alexander Panossian, Ean-Jeong Seo, Thomas EfferthGraphical abstract (Source: Synergy)
Source: Synergy - October 10, 2018 Category: Molecular Biology Source Type: research
Omega-3 fatty acids moderate oxidative and proinflammatory events in experimental hepatotoxicity in Wistar rats: comparison with livolin
Publication date: December 2018Source: Synergy, Volume 7Author(s): Luqman Aribidesi Olayaki, Wale Johnson Adeyemi, Joseph Sunday Yinusa, Grace Amarachi AdedayoAbstractDietary supplementation with omega-3 fatty acids have been advocated because of the global preference for the omega-6 fatty acids - rich Western style diet. The study investigated the effects of omega-3 fatty acids (combination of N-3: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); EPA/DHA ratio = 3/2) compared to livolin (Phosphatidylcholin + vitamins) on biochemical and haematological parameters in diclofenac (DF) - induced hepatotoxici...
Source: Synergy - September 12, 2018 Category: Molecular Biology Source Type: research
Omega – 3 Fatty Acids Moderates Oxidative and Pro-inflammatory Events in Experimental Hepatotoxicity in Wistar Rats: Comparisons with Livolin
Publication date: Available online 31 August 2018Source: SynergyAuthor(s): Luqman Aribidesi Olayaki, Wale Johnson Adeyemi, Joseph Sunday Yinusa, Grace Amarachi AdedayoAbstractDietary supplementation with omega-3 fatty acids have been advocated because of the global preference for the omega-6 fatty acids - rich Western style diet. The study investigated the effects of omega-3 fatty acids (combination of N-3: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); EPA/DHA ratio = 3/2) compared to livolin (Phosphatidylcholin + vitamins) on biochemical and haematological parameters in diclofenac (DF) -induced hepat...
Source: Synergy - September 1, 2018 Category: Molecular Biology Source Type: research
Methotrexate induced cell death mechanisms in MCF-7 adenocarcinoma breast cancer cells: Enhanced cytotoxicity following dff45-siRNA pre-treatment
Publication date: Available online 30 August 2018Source: SynergyAuthor(s): Fatemeh Kiani, Negin Rasouli, Tahereh Kashkoolinejad, Shahrokh Safarian, Seyed Jalal Zargar, Nader SheibaniAbstractThere are many efforts to diminish risks associated with the use of cancer chemotherapeutic agents through design and utilization of new strategies including gene therapy. We previously showed knockdown of dff45 or overexpression of dff40, the important apoptosis regulators, resulted in enhanced sensitization of cancer cells to chemotherapeutic agents. Here we show that pre-treatment with dff45-siRNA additively increased the overall cyt...
Source: Synergy - August 31, 2018 Category: Molecular Biology Source Type: research
Regulation of monocyte redox balance by 1,8-cineole (eucalyptol) controls oxidative stress and pro-inflammatory responses in vitro: a new option to increase the antioxidant effects of combined respiratory therapy with budesonide and formoterol?
ConclusionsWe report an inhibition of superoxide anions, balancing partial dismutation of superoxide anions and independent inhibition of H2O2 by 1,8-cineole. These results suggest a non-specific combined, antioxidant and anti-inflammatory mode of action of 1,8-cineole as bifunctional drug for further clinical evaluation in mild to severe COPD and as adjunctive therapy to control disease progression. (Source: Synergy)
Source: Synergy - July 19, 2018 Category: Molecular Biology Source Type: research
Editorial Board
Publication date: December 2017Source: Synergy, Volume 5, Part BAuthor(s): (Source: Synergy)
Source: Synergy - July 11, 2018 Category: Molecular Biology Source Type: research
Potential pharmacodynamic and pharmacokinetic interaction of pomegranate juice and nateglinide against diabetis induced complications in rats
ConclusionIn comparison to NAT alone, the combination of PJ and NAT improved alloxan induced parameters of diabetic complications probably due to a higher bioavailability of NAT. This phenomenon deservers further investigations.Graphical abstract (Source: Synergy)
Source: Synergy - July 11, 2018 Category: Molecular Biology Source Type: research
Curcumin synergizes with the endocannabinoid reuptake inhibitor OMDM-2 in human MCF-7 breast cancer and U-87 glioblastoma cells
ConclusionThese findings provide experimental support for the use of curcumin as a modulator of tumor cell pharmacointeraction in cannabinoid based therapies. To achieve synergism dose ratios should be established for each cell type and ratiometric dosing be considered.Graphical abstract (Source: Synergy)
Source: Synergy - July 11, 2018 Category: Molecular Biology Source Type: research
In vitro and in silico anticancer effect of combined crude acetone extracts of Plumbago zeylanica L., Limonia acidissima L. and Artocarpus heterophyllus Lam
ConclusionThe CCAE showed significant antioxidant activity, brine shrimp toxicity and anticancer activity. The GC–MS analysis revealed with a number of active compounds; the binding energy was high in several ligands for certain cancer receptors. The CCAE should be further investigated in the context of breast cancer and synergistic activities of its constituents.Graphical abstract (Source: Synergy)
Source: Synergy - July 11, 2018 Category: Molecular Biology Source Type: research
The Combination Index (CI < 1) As the Definition of Synergism and of Synergy Claims
Publication date: Available online 27 April 2018Source: SynergyAuthor(s): Ting-Chao ChouAbstractThe unified theory of the median-effect equation (MEE) of the mass-action law (MAL) indicates that dose and effect are interchangeable, and all dose-effect curves can be transformed into straight- lines by the median-effect plot. Therefore, it allows pharmacodynamics (PD) analysis using small size experimentation for in vitro and in vivo studies. Further, extension of MEE has proven that the Combination Index Equation (CIE) which defines Synergism (CI < 1), Additive Effect (CI = 1) and Antagonism (CI > 1), can be...
Source: Synergy - July 11, 2018 Category: Molecular Biology Source Type: research
Editorial Board
Publication date: June 2018Source: Synergy, Volume 6Author(s): (Source: Synergy)
Source: Synergy - July 11, 2018 Category: Molecular Biology Source Type: research
Synergistic effects and their potential significance for the influence of natural intensities of environmental factors on cell growth
ConclusionThe existence of optimal conditions providing the greatest synergistic effect and its dependence on the intensity of applied agents was demonstrated. Common patterns were identified. It is concluded that synergistic interactions are important for the evaluation of biological consequences and risk assessment from combined effects at low intensities of ionizing radiation, UV-light, electromagnetic fields, or small concentration of chemicals.Graphical abstract (Source: Synergy)
Source: Synergy - July 11, 2018 Category: Molecular Biology Source Type: research
Editorial Board
Publication date: December 2017Source: Synergy, Volume 5, Part BAuthor(s): (Source: Synergy)
Source: Synergy - July 6, 2018 Category: Molecular Biology Source Type: research
Potential pharmacodynamic and pharmacokinetic interaction of pomegranate juice and nateglinide against diabetis induced complications in rats
ConclusionIn comparison to NAT alone, the combination of PJ and NAT improved alloxan induced parameters of diabetic complications probably due to a higher bioavailability of NAT. This phenomenon deservers further investigations.Graphical abstract (Source: Synergy)
Source: Synergy - July 6, 2018 Category: Molecular Biology Source Type: research
