Curcumin synergizes with the endocannabinoid reuptake inhibitor OMDM-2 in human MCF-7 breast cancer and U-87 glioblastoma cells
ConclusionThese findings provide experimental support for the use of curcumin as a modulator of tumor cell pharmacointeraction in cannabinoid based therapies. To achieve synergism dose ratios should be established for each cell type and ratiometric dosing be considered.Graphical abstract (Source: Synergy)
Source: Synergy - July 6, 2018 Category: Molecular Biology Source Type: research
In vitro and in silico anticancer effect of combined crude acetone extracts of Plumbago zeylanica L., Limonia acidissima L. and Artocarpus heterophyllus Lam
ConclusionThe CCAE showed significant antioxidant activity, brine shrimp toxicity and anticancer activity. The GC–MS analysis revealed with a number of active compounds; the binding energy was high in several ligands for certain cancer receptors. The CCAE should be further investigated in the context of breast cancer and synergistic activities of its constituents.Graphical abstract (Source: Synergy)
Source: Synergy - July 6, 2018 Category: Molecular Biology Source Type: research
The Combination Index (CI < 1) As the Definition of Synergism and of Synergy Claims
Publication date: Available online 27 April 2018Source: SynergyAuthor(s): Ting-Chao ChouAbstractThe unified theory of the median-effect equation (MEE) of the mass-action law (MAL) indicates that dose and effect are interchangeable, and all dose-effect curves can be transformed into straight- lines by the median-effect plot. Therefore, it allows pharmacodynamics (PD) analysis using small size experimentation for in vitro and in vivo studies. Further, extension of MEE has proven that the Combination Index Equation (CIE) which defines Synergism (CI < 1), Additive Effect (CI = 1) and Antagonism (CI > 1), can be...
Source: Synergy - July 6, 2018 Category: Molecular Biology Source Type: research
Editorial Board
Publication date: June 2018Source: Synergy, Volume 6Author(s): (Source: Synergy)
Source: Synergy - July 6, 2018 Category: Molecular Biology Source Type: research
Synergistic effects and their potential significance for the influence of natural intensities of environmental factors on cell growth
ConclusionThe existence of optimal conditions providing the greatest synergistic effect and its dependence on the intensity of applied agents was demonstrated. Common patterns were identified. It is concluded that synergistic interactions are important for the evaluation of biological consequences and risk assessment from combined effects at low intensities of ionizing radiation, UV-light, electromagnetic fields, or small concentration of chemicals.Graphical abstract (Source: Synergy)
Source: Synergy - July 6, 2018 Category: Molecular Biology Source Type: research
The Combination Index (CI & lt; 1) As the Definition of Synergism and of Synergy Claims
Publication date: Available online 27 April 2018 Source:Synergy Author(s): Ting-Chao Chou The unified theory of the median-effect equation (MEE) of the mass-action law (MAL) indicates that dose and effect are interchangeable, and all dose-effect curves can be transformed into straight- lines by the median-effect plot. Therefore, it allows pharmacodynamics (PD) analysis using small size experimentation for in vitro and in vivo studies. Further, extension of MEE has proven that the Combination Index Equation (CIE) which defines Synergism (CI < 1), Additive Effect (CI = 1) and Antagonism (CI > 1),...
Source: Synergy - April 27, 2018 Category: Molecular Biology Source Type: research
Synergistic effects and their potential significance for the influence of natural intensities of environmental factors on cell growth
Conclusion The existence of optimal conditions providing the greatest synergistic effect and its dependence on the intensity of applied agents was demonstrated. Common patterns were identified. It is concluded that synergistic interactions are important for the evaluation of biological consequences and risk assessment from combined effects at low intensities of ionizing radiation, UV-light, electromagnetic fields, or small concentration of chemicals. Graphical abstract (Source: Synergy)
Source: Synergy - December 12, 2017 Category: Molecular Biology Source Type: research
In vitro and In silico anticancer effect of combined crude acetone extracts of Plumbago zeylanica L., Limonia acidissima L. and Artocarpus heterophyllus Lam
Conclusion The CCAE showed significant antioxidant activity, brine shrimp toxicity and anticancer activity. The GC–MS analysis revealed many active compounds; the binding energy was high in several ligands for certain cancer receptors. The CCAE could be probed further for the treatment of cancer Graphical abstract (Source: Synergy)
Source: Synergy - December 6, 2017 Category: Molecular Biology Source Type: research
Potential pharmacodynamic and pharmacokinetic interaction of pomegranate juice and nateglinide against diabetic induced complications in rats
Conclusion In comparison to NAT alone, the combination of PJ and NAT improved alloxan induced parameters of diabetic complications probably due to a higher bioavailability of NAT. This phenomenon deservers further investigations. Graphical abstract (Source: Synergy)
Source: Synergy - November 24, 2017 Category: Molecular Biology Source Type: research
Curcumin synergizes with the endocannabinoid reuptake inhibitor OMDM-2 in human MCF-7 breast cancer and U-87 glioblastoma cells
Conclusion These findings provide experimental support for the use of curcumin as a modulator of tumor cell pharmacointeraction in cannabinoid based therapies. To achieve synergism dose ratios should be established for each cell type and ratiometric dosing be considered. Graphical abstract (Source: Synergy)
Source: Synergy - November 23, 2017 Category: Molecular Biology Source Type: research
The combination of the extracts of Rauwolfia vomitoria and Gongronema latifolium show protective effects on the cerebellumline
Conclusion RV+GL combination ameliorates RV induced-cerebellar cells trauma, but not their proliferation. Graphical abstract (Source: Synergy)
Source: Synergy - October 7, 2017 Category: Molecular Biology Source Type: research
Combinational effect of Paclitaxel and Clotrimazole on human breast cancer: proof for synergistic interaction
Publication date: Available online 12 September 2017 Source:Synergy Author(s): Arun Sharma, Vineet Mehta, Arun Parashar, Udayabanu Malairaman Study was aimed to determine the anti-cancerous co-effect of paclitaxel (PAX) with clotrimazole (CLZ) on breast cancer cells and to explore the mechanism involved. Cell viability was evaluated through MTT assay followed by CompuSyn simulations to evaluate, whether the effect of PAX and CLZ in combination was additive, synergistic or antagonistic. Nuclear morphology was examined through DAPI/PI staining and AO/EtBr staining. Level of H2O2 and NO were evaluated to detect reactive...
Source: Synergy - September 13, 2017 Category: Molecular Biology Source Type: research
Involvement of the monoaminergic system in the antidepressant-like effect of the crude extract of Mentha piperita (Lamiaceae) in the forced swimming test in mice
Publication date: Available online 9 September 2017 Source:Synergy Author(s): Saeid Abbasi-Maleki, Azam Bakhtiarian, Vahid Nikoui The aim of the present study was to investigate the involvement of the monoaminergic system in antidepressant-like effects of a characterized ethanolic extract of Mentha piperita (MP) in the forced swimming test (FST) in male mice. The animals were intraperitoneally (i.p.) treated with the MP extract (50–400mg/kg) one hour before FST. To examine the involvement of the monoaminergic system in the antidepressant-like effect of MP, receptor antagonists were administrated fifteen minutes prio...
Source: Synergy - September 10, 2017 Category: Molecular Biology Source Type: research
Anti-inflammatory effects of 1,8-cineole (eucalyptol) improve glucocorticoid effects in vitro: a novel approach of steroid-sparing add-on therapy for COPD and asthma?
Conclusions These results suggest a new mode of action of 1,8-cineole as non-steroidal, anti-inflammatory agent. Its potential to suppress airway inflammation and to improve the efficacy of inhaled steroids in COPD and asthma should be clinically further investigated. Graphical abstract (Source: Synergy)
Source: Synergy - August 13, 2017 Category: Molecular Biology Source Type: research
Substance P-induced nerve growth factor release is down-regulated by serotonin in serum-free cultured osteoarthritis macrophage-like synovial cells
Conclusion SP might trigger synovitis via a self-perpetuating feedback loop in OA pain. The SP-mediated response is downregulated by a combination of 5-HT. The synergistic or antagonistic effect of SP, 5-HT and IL-1β should be further investigated. Graphical abstract (Source: Synergy)
Source: Synergy - August 13, 2017 Category: Molecular Biology Source Type: research
