From additivity to synergism – A modelling perspective
Publication date: September 2014 Source:Synergy, Volume 1, Issue 1 Author(s): Christian Ritz , Jens C. Streibig Interest in synergistic or antagonistic effects through mixture experiments has grown immensely over the past two decades, not the least within in pharmacology and toxicology. Several definitions of reference models exist; one commonly used reference model is concentration or dose addition, which assumes compounds, when administrated simultaneously, do not interfere with each other at the site of action. We focus on statistical modelling that allows evaluation of dose addition. We will describe several stat...
Source: Synergy - November 7, 2014 Category: Molecular Biology Source Type: research
Frequently asked questions in drug combinations and the mass-action law-based answers
This article reviews the current status and enlists the frequently occurred pit-falls, misconceptions and common errors in drug combination studies. The questions and issues are contemplated to be answered and clarified with the physico-chemical algorithms of the mass-action law, specifically with the unified theory of the median-effect equation and its combination index theorem for drug combinations. The derived theory, algorithm and its computer simulation lead to a quantitative indexed bioinformatics, and econo-green bio-research using small number of data points. (Source: Synergy)
Source: Synergy - November 7, 2014 Category: Molecular Biology Source Type: research
Adenosine receptors: Intermembrane receptor-receptor interactions in the brain
Publication date: Available online 30 October 2014 Source:Synergy Author(s): Karen Nieber , Sebastian Michael In the vertebrate central nervous system (CNS) the modulation of synaptic transmission by metabotropic or ionotropic receptors is an important source of control and dynamical adjustment in synaptic activity and can contribute to synergistic or antagonistic effects. Adenosine is released from most cells, including Sneurons and glial cells. Once in the extracellular space, adenosine modifies cell functioning by operating G-protein-coupled receptors. In general, adenosine has been found to act in concert with ot...
Source: Synergy - November 7, 2014 Category: Molecular Biology Source Type: research
