Immunomodulatory and antioxidants properties of fixed combination of fish oil with plant extracts
Publication date: October 2015 Source:Synergy, Volume 2, Issue 3 Author(s): Olga N. Pozharitskaya, Alexander N. Shikov, Vera M. Kosman, Arina I. Selezneva, Irina N. Urakova, Marina N. Makarova, Valery G. Makarov The immunomodulatory and antioxidant properties of fixed combination of fish oil with Schisandra chinensis oil extract (CFS) and Matricaria chamomilla oil extract (CFM) (5 volumes of fish oil with 1 volume of plant extract) were evaluated in vivo and in vitro. The fixed combinations exhibited 27.8% (CFS) and 21.7% (CFM) inhibition of the delayed-type hypersensitivity in mice at 5460mg/kg dose whic...
Source: Synergy - August 7, 2015 Category: Molecular Biology Source Type: research
Immunomodulatory and antoxidants properties of fixed combination of fish oil with plant extracts
Publication date: Available online 18 July 2015 Source:Synergy Author(s): Olga N. Pozharitskaya, Alexander N. Shikov, Vera M. Kosman, Arina I. Selezneva, Irina N. Urakova, Marina N. Makarova, Valery G. Makarov The immunomodulatory and antioxidant properties of fixed combination of fish oil with Schisandra chinensis oil extract (CFS) and Matricaria chamomilla oil extract (CFM) (5 volumes of fish oil with 1 volume of plant extract) were evaluated in vivo and in vitro. The fixed combinations exhibited 27.8% (CFS) and 21.7% (CFM) inhibition of the delayed-type hypersensitivity in mice at 5460mg/kg dose which ...
Source: Synergy - July 18, 2015 Category: Molecular Biology Source Type: research
EGFR Inhibitors in Combination with Cyclopamine as Chemotherapeutic Strategy for Treating Breast Cancer
Conclusions Combination of cyclopamine and afatinib or gefitinib leads to a supra-additive inhibition of MDA-MB-231 and MCF-7 cell proliferation and was found to be dose, time, cell line and schedule dependent. Also, combination therapy more effectively induced apoptosis, inhibited cell migration and downregulated Gli-1 expression compared to monotherapy in breast cancer cells. Graphical abstract (Source: Synergy)
Source: Synergy - July 11, 2015 Category: Molecular Biology Source Type: research
Combined effect of paclitaxel and piperine on a MCF-7 breast cancer cell line in vitro: evidence of a synergistic interaction
Publication date: Available online 23 April 2015 Source:Synergy Author(s): M.N. Motiwala , V.D. Rangari In spite of increasingly improved treatment options breast cancer remains a severe life threatening disease. Major challenges in cancer chemotherapies of today are increasing health care costs, the effect of anticancer drugs on healthier cells, complex multiple interconnected nodes of cell signaling and multidrug resistance. Recently piperine, a major bioactive constituent of black and long pepper (Piper nigrum L., Piper longum L.) was reported to support the reduction of lung cancer in mice, but also enhance the b...
Source: Synergy - April 23, 2015 Category: Molecular Biology Source Type: research
Adenosine receptors: Intermembrane receptor–receptor interactions in the brain
Publication date: December 2014 Source:Synergy, Volume 1, Issue 2 Author(s): Karen Nieber , Sebastian Michael In the vertebrate central nervous system (CNS) the modulation of synaptic transmission by metabotropic or ionotropic receptors is an important source of control and dynamical adjustment in synaptic activity and can contribute to synergistic or antagonistic effects. Adenosine is released from most cells, including Sneurons and glial cells. Once in the extracellular space, adenosine modifies cell functioning by operating G-protein-coupled receptors. In general, adenosine has been found to act in concert with ot...
Source: Synergy - November 16, 2014 Category: Molecular Biology Source Type: research
Differential Transcriptional Profiles in HepG2 cells after the exposure to a chemically characterized complex preparation of Silybi Mariani Fructus and its chemically-defined constituent Silybin
Conclusion Although cell proliferation was not affected by silybin A+B or the extract, gene expression profiles revealed differently activated cellular mechanisms. This emphasizes that the biological function of multicomponent mixtures may differ widely from the one of the designated bioactive constituent. A comparative gene expression is likely to expidize bioguided fractionations with the identification of relevant signal cascades and networks which allow to generate hypotheses for antagonistic, additive or synergistic cellular processes. (Source: Synergy)
Source: Synergy - November 12, 2014 Category: Molecular Biology Source Type: research
Antimicrobial activity of Mentha piperita essential oil in combination with silver ions
Publication date: Available online 11 November 2014 Source:Synergy Author(s): Aijaz Ahmad , Amber Khan , Neha Samber , Nikhat Manzoor Peppermint (Mentha piperita L.) is time-honored for its medicinal properties and its antimicrobial characteristics are well established and supported in the literature. In the present study the composition and in vitro antimicrobial activity of Mentha piperita essential oil (MpEO) alone and in combination with silver ions (Ag+) against the cultures of Escherichia coli, Staphylococcus aureus and Candida albicans is highlighted. The nature of the interaction was studied from fractional...
Source: Synergy - November 12, 2014 Category: Molecular Biology Source Type: research
Effectiveness versus toxicity: How to assess combinations?
Publication date: September 2014 Source:Synergy, Volume 1, Issue 1 Author(s): Olaf Kelber , Heba Abdel-Aziz , Dieter Schrenk The pharmacology and toxicology of combination medicinal products are preferentially studied using the combination as the test substance, as testing of the isolated constituents does not allow to detect potential sub- or supra-additive effects. This applies as well to combinations of chemically defined pharmaceutically active ingredients as to herbal medicinal products, which typically contain a combination of hundreds or even thousands of constituents as the active substance. (Source: Synergy)
Source: Synergy - November 7, 2014 Category: Molecular Biology Source Type: research
The development of fixed drug combinations – The example of Aspirin® Complex
Publication date: September 2014 Source:Synergy, Volume 1, Issue 1 Author(s): Uwe Gessner Aspirin® Complex is a fixed drug combination containing acetylsalicylic acid (ASA) and pseudoephedrine hydrochloride (PSE) as active ingredients, which have pain-relieving, anti-inflammatory, fever reducing and nasal decongestant properties. The pharmaceutical form is granules for oral suspension. Each sachet contains 500mg ASA and 30mg PSE. (Source: Synergy)
Source: Synergy - November 7, 2014 Category: Molecular Biology Source Type: research
A personalised medicine drug sensitivity and resistance testing platform and utilisation of acoustic droplet ejection at the Institute for Molecular Medicine Finland
Publication date: September 2014 Source:Synergy, Volume 1, Issue 1 Author(s): Jani Saarela , Evgeny Kulesskiy , Karoliina Laamanen , Tea Pemovska , Vilja Pietiäinen , Swapnil Potdar , Carina von Schantz-Fant , Laura Turunen , Päivi Östling , Krister Wennerberg The High Throughput Biomedicine (HTB) unit at FIMM Technology Centre provides a wide range of biomedical high throughput assays. In collaboration with research groups and the Hospital District of Helsinki and Uusimaa, we have set up drug sensitivity and resistance testing (DSRT) platform with a set of 450 approved and investigational oncology drugs o...
Source: Synergy - November 7, 2014 Category: Molecular Biology Source Type: research
Novel options of complex combinatory screening by digital dispensing technology
Publication date: September 2014 Source:Synergy, Volume 1, Issue 1 Author(s): M. Biegger , M. Counsell , F. Gyger , B. Maurer , E. Würsten , B. Merzenich (Source: Synergy)
Source: Synergy - November 7, 2014 Category: Molecular Biology Source Type: research
Status quo and future developments of combinations of medicinal products
Publication date: September 2014 Source:Synergy, Volume 1, Issue 1 Author(s): J.K. Schweim , H.G. Schweim Combinations of medicinal products were in common use during the 1950s and 1960s. These combinations were rarely a result of a rational development, but rather based on empirical experience. Following the German Drug Law (AMG) in 1976, a rational pharmacological justification for combinations of medicinal products became mandatory. Simultaneously cases of certain fixed combinations were found to possess high health risks, leading to the opinion that an effective and safe therapy requires an individual dosing of ...
Source: Synergy - November 7, 2014 Category: Molecular Biology Source Type: research
Combination screening of synthetic drugs and plant derived natural products—Potential and challenges for drug development
Publication date: September 2014 Source:Synergy, Volume 1, Issue 1 Author(s): Gudrun Sigrid Ulrich-Merzenich Plants are a precious source for medicine and drug development. An estimated one third of our present medicines are derived from natural sources – either directly isolated, synthesized or semi-synthesized by structural modification of their natural compounds. Well known examples are colchicine, morphine, semi-synthetic aspirin, taxol or penicillin. However, drug development from natural sources as well as by synthesis is presently facing a set back. Most new drugs fail in the step from the preclinic to the cl...
Source: Synergy - November 7, 2014 Category: Molecular Biology Source Type: research
Overcoming of P-glycoprotein-mediated multidrug resistance of tumors in vivo by drug combinations
Publication date: September 2014 Source:Synergy, Volume 1, Issue 1 Author(s): Mohamed Saeed , Maen Zeino , Onat Kadioglu , Manfred Volm , Thomas Efferth Inhibition of P-glycoprotein represents an attractive possibility to modulate resistance of cancer cells to anticancer drugs. One major strategy to overcome P-glycoprotein-mediated multidrug resistance (MDR) of tumors is to increase intracellular concentrations of anticancer drugs. This can be achieved by blocking of P-glycoprotein-mediated drug efflux using synthetic or natural small molecules or monoclonal antibodies, which bind to various parts of the efflux ch...
Source: Synergy - November 7, 2014 Category: Molecular Biology Source Type: research
Searching for synergy in silico, in vitro and in vivo
Publication date: September 2014 Source:Synergy, Volume 1, Issue 1 Author(s): Nikolaus J. Sucher In this paper, I examine the role of the idea of synergy in life science research using examples in the fields of pharmacology/toxicology, molecular genetics and development, biochemistry, ecology and metabolic engineering. The research shows that synergy exhibits scale invariance. Small molecules act synergistically in the activation of single receptor molecules. Proteins function synergistically in development, metabolism and signaling. Synergy was found in the interaction between communities of organisms. Synergy manife...
Source: Synergy - November 7, 2014 Category: Molecular Biology Source Type: research
