In vitro synergistic interactions of Protocatechuic acid and Chlorogenic acid in combination with antibiotics against animal pathogens
ConclusionsThe study showed that Protocatechuic acid and Chlorogenic acid can enhance the antimicrobial activity of most of the tested antibiotics against the bacterial strains of Escherichia coli, Staphylococcus aureus, Streptococcus iniae, Proteus mirabilis.Graphical abstract (Source: Synergy)
Source: Synergy - September 10, 2019 Category: Molecular Biology Source Type: research
Publisher Note
Publication date: June 2019Source: Synergy, Volume 8Author(s): (Source: Synergy)
Source: Synergy - June 8, 2019 Category: Molecular Biology Source Type: research
Publisher's Note
Publication date: Available online 1 June 2019Source: SynergyAuthor(s): (Source: Synergy)
Source: Synergy - June 1, 2019 Category: Molecular Biology Source Type: research
Essential oils: Fragrant pools of antimicrobial synergism explored
Publication date: Available online 29 May 2019Source: SynergyAuthor(s): Sandy van Vuuren, Ane Orchard, Alvaro Viljoen (Source: Synergy)
Source: Synergy - May 30, 2019 Category: Molecular Biology Source Type: research
Computerized quantification of drugs synergism in animal studies or in clinical trials using only ten data points
This article presents two examples for drug combinations in vivo: (i) in animals (anticancer drug combination against human HCT-116 colon carcinoma xenografts in nude mice, Taxotere + T607) and (ii) in a clinical trial (anti-retroviral drug combinations against HIV/AIDS, AZT + INF). Only 36 patients respectively only 66 nude mice were required. Both examples require only ten data points (D1, D2 and [D1+D2], each with 3 doses plus one control) to quantitatively determine synergism or antagonism with the CompuSyn software.Graphical abstract (Source: Synergy)
Source: Synergy - May 30, 2019 Category: Molecular Biology Source Type: research
Making Connections: Linking redolent synergy to the aroma therapeutic treatment of respiratory tract infections
Publication date: Available online 14 May 2019Source: SynergyAuthor(s): Stephanie de Rapper, Sandy van Vuuren, Alvaro Viljoen (Source: Synergy)
Source: Synergy - May 15, 2019 Category: Molecular Biology Source Type: research
Combination of chemotherapy, radiotherapy and hyperthermia in vitro
Publication date: Available online 14 May 2019Source: SynergyAuthor(s): Helena C. Besse, Clemens Bos, Maurice M.J.M Zandvliet, Chrit T.W. Moonen, Roel Deckers (Source: Synergy)
Source: Synergy - May 15, 2019 Category: Molecular Biology Source Type: research
In Memory of Paul Talalay
Publication date: Available online 26 March 2019Source: SynergyAuthor(s): Gudrun Ulrich-Merzenich (Source: Synergy)
Source: Synergy - March 27, 2019 Category: Molecular Biology Source Type: research
Implementation of the Chou-Talalay method for studying the in vitro pharmacodynamic interactions of binary and ternary drug combinations on MDA-MB-231 triple negative breast cancer cells
Publication date: Available online 20 March 2019Source: SynergyAuthor(s): Ahmed Elwakeel, Hadeer Soudan, Ahmed Aldoksh, Manal Shalaby, Maha Eldemellawy, Doaa Ghareeb, Myriam Abouseif, Amira Fayad, Mostafa Hassan, Hesham SaeedAbstractTriple Negative Breast Cancer (TNBC) treatment is more challenging than other subtypes of breast malignancy and due to the lack of markers for the molecularly targeted therapies (ER, PR, and HER-2/Neu), the conventional chemotherapeutic agents are still the mainstay of the therapeutic protocols of its patients. Unfortunately, the initial good response to the chemotherapy eventually turns into a...
Source: Synergy - March 21, 2019 Category: Molecular Biology Source Type: research
The effects of fluid shear stress and O2 concentration on the phosphorylation of eNOS at Ser635 in endothelial cells
Publication date: Available online 20 March 2019Source: SynergyAuthor(s): Toshihiro Sera, Keiichi Ueyama, Alireza Karimi, Susumu KudoAbstractUnder hypoxic conditions, NO plays an important role in regulating O2 delivery by controlling local blood vessel relaxation. NO is primarily produced by endothelial NO synthase (eNOS), which is reportedly phosphorylated at Ser635 and thereby activated under conditions of fluid shear stress and O2 concentration. The aim of this work was to investigate the effects of fluid shear stress and O2 concentration on the phosphorylation of eNOS at Ser635. Bovine aortic endothelial cells were ex...
Source: Synergy - March 21, 2019 Category: Molecular Biology Source Type: research
Effects of salmon calcitonin and omega – 3 fatty acids on selected biomarkers in experimental diabetic – osteoarthritic rats
In conclusion, the co-administration of Sct and N-3, and not the single therapy, could be preferably used in the management of diabetic-osteoarthritic state.Graphical abstract (Source: Synergy)
Source: Synergy - December 28, 2018 Category: Molecular Biology Source Type: research
Editorial Board
Publication date: December 2018Source: Synergy, Volume 7Author(s): (Source: Synergy)
Source: Synergy - November 23, 2018 Category: Molecular Biology Source Type: research
Synergy: Easier to say than to prove
Publication date: Available online 28 October 2018Source: SynergyAuthor(s): R. Verpoorte, H.K. Kim, Y.H. Choi (Source: Synergy)
Source: Synergy - October 29, 2018 Category: Molecular Biology Source Type: research
Exploring Synergy in Ayurveda and Traditional Indian Systems of Medicine
Publication date: Available online 23 October 2018Source: SynergyAuthor(s): Pulok K Mukherjee, Subhadip Banerjee, Amit KarAbstractSynergy is a phenomenon of life. It has been observed that combinatory treatments may achieve more stable ‘‘network responses’’ than single drugs. Drug combination treatments are routinely applied in an increasing number of disciplines in medicine. Single drug treatments are less effective than drug combinations in complex treatment regimes. Plant derived herbal drugs or phytopharmaceuticals can be considered a natural “model” for combinatory treatments. Specific compositions of mult...
Source: Synergy - October 24, 2018 Category: Molecular Biology Source Type: research
Effect of quercetin on myocardial potency of curcumin against ischemia reperfusion induced myocardial toxicity
ConclusionFrom this study it can be concluded that combination of CUR and QUE exhibited profound protection compared to CUR alone treated group against IRI induced myocardial toxicity. Findings of pharmacokinetic interaction justified the results of pharmacodynamic interaction. (Source: Synergy)
Source: Synergy - October 19, 2018 Category: Molecular Biology Source Type: research
