Comparison of two ASC-derived therapeutics in an in vitro OA model: secretome versus extracellular vesicles
In the last years, several clinical trials have proved the safety and efficacy of adipose-derived stem/stromal cells (ASC) in contrasting osteoarthritis (OA). Since ASC act mainly through paracrine mechanisms,... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 3, 2020 Category: Stem Cells Authors: Chiara Giannasi, Stefania Niada, Cinzia Magagnotti, Enrico Ragni, Annapaola Andolfo and Anna Teresa Brini Tags: Research Source Type: research
Synthesis of aligned porous polyethylene glycol/silk fibroin/hydroxyapatite scaffolds for osteoinduction in bone tissue engineering
In this study, the effect of the biophysical microenvironment on rat bone m... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 3, 2020 Category: Stem Cells Authors: Yuchao Yang, Yanting Feng, Rongmei Qu, Qingtao Li, Dongming Rong, Tingyu Fan, Yiting Yang, Bing Sun, Zhenyu Bi, Asmat Ullah Khan, Ting Deng, Jingxing Dai and Jun Ouyang Tags: Research Source Type: research
What is the impact of human umbilical cord mesenchymal stem cell transplantation on clinical treatment?
Human umbilical cord mesenchymal stem cells (HUC-MSCs) present in the umbilical cord tissue are self-renewing and multipotent. They can renew themselves continuously and, under certain conditions, differentiat... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 1, 2020 Category: Stem Cells Authors: Qixin Xie, Rui Liu, Jia Jiang, Jing Peng, Chunyan Yang, Wen Zhang, Sheng Wang and Jing Song Tags: Review Source Type: research
Circ6401, a novel circular RNA, is implicated in repair of the damaged endometrium by Wharton ’s jelly-derived mesenchymal stem cells through regulation of the miR-29b-1-5p/RAP1B axis
Accumulating evidence indicates that mesenchymal stem cells (MSCs) exert tissue repair effects and therapeutic angiogenesis through their noncoding RNAs (ncRNAs). Our previous studies showed that MSCs derived ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 1, 2020 Category: Stem Cells Authors: Qin Shi, Baolan Sun, Di Wang, Yi Zhu, Xinxin Zhao, Xiaoqing Yang and Yuquan Zhang Tags: Research Source Type: research
Comparison of reversal of rat pulmonary fibrosis of nintedanib, pirfenidone, and human umbilical mesenchymal stem cells from Wharton ’s jelly
The present study compared the effects of antifibrotic medications, pirfenidone, and nintedanib, with transplantation of human umbilical mesenchymal stem cells (HUMSCs) in restoring rat pulmonary fibrosis (PF). (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 30, 2020 Category: Stem Cells Authors: Kuo-An Chu, Chang-Ching Yeh, Fu-Hsien Kuo, Wen-Ren Lin, Chien-Wei Hsu, Tien-Hua Chen and Yu-Show Fu Tags: Research Source Type: research
Detection of viral RNA fragments in human iPSC cardiomyocytes following treatment with extracellular vesicles from SARS-CoV-2 coding sequence overexpressing lung epithelial cells
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global pandemic. The prevalence/severity of COVID-19 is higher among patients with cardiovasc... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 30, 2020 Category: Stem Cells Authors: Youjeong Kwon, Sarath Babu Nukala, Shubhi Srivastava, Hiroe Miyamoto, Nur Izzah Ismail, Jordan Jousma, Jalees Rehman, Sang-Bing Ong, Won Hee Lee and Sang-Ging Ong Tags: Letter Source Type: research
ER stress arm XBP1s plays a pivotal role in proteasome inhibition-induced bone formation
Bone destruction is a hallmark of multiple myeloma (MM). It has been reported that proteasome inhibitors (PIs) can reduce bone resorption and increase bone formation in MM patients, but the underlying mechanis... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 30, 2020 Category: Stem Cells Authors: Dan Zhang, Kim De Veirman, Rong Fan, Qiang Jian, Yuchen Zhang, Li Lei, Holly Evans, Yanmeng Wang, Lei Lei, Baiyan Wang, Ramone A. Williamson, Andrew Chantry, Pengcheng He, Ang Li, Hendrik De Raeve, Karin Vanderkerken & hellip; Tags: Research Source Type: research
MicroRNA-enriched small extracellular vesicles possess odonto-immunomodulatory properties for modulating the immune response of macrophages and promoting odontogenesis
To investigate the odonto-immunomodulatory properties of dental pulp stem cell-derived small extracellular vesicles (DPSCs-sEV), which promote odontogenesis by switching macrophages toward the pro-healing M2 p... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 30, 2020 Category: Stem Cells Authors: Jianmao Zheng, Yuanyuan Kong, Xiaoli Hu, Zhishan Li, Yaoyin Li, Yingqun Zhong, Xi Wei and Junqi Ling Tags: Research Source Type: research
Long noncoding RNA MEG3 blocks telomerase activity in human liver cancer stem cells epigenetically
MEG3 downregulated the expression in several tumors and inhibits human tumorigenesis. But so far, the mechanism of MEG3 in tumorigenesis is still unclear. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 30, 2020 Category: Stem Cells Authors: Xiaoxue Jiang, Liyan Wang, Sijie Xie, Yingjie Chen, Shuting Song, Yanan Lu and Dongdong Lu Tags: Research Source Type: research
Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell-based in vitro disease modeling: convergence of schizophrenia- and autism-related cellular phenotypes
De novo mutations (DNMs) have been implicated in the etiology of schizophrenia (SZ), a chronic debilitating psychiatric disorder characterized by hallucinations, delusions, cognitive dysfunction, and decreased... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 27, 2020 Category: Stem Cells Authors: Edit Hathy, Eszter Szab ó, Nóra Varga, Zsuzsa Erdei, Csongor Tordai, Boróka Czehlár, Máté Baradits, Bálint Jezsó, Júlia Koller, László Nagy, Mária Judit Molnár, László Homolya, Zsófia Nemoda, Ágota Apáti and János M. Réthelyi Tags: Research Source Type: research
IRF-1 expressed in the inner cell mass of the porcine early blastocyst enhances the pluripotency of induced pluripotent stem cells
Despite years of research, porcine-induced pluripotent stem cells (piPSCs) with germline chimeric capacity have not been established. Furthermore, the key transcription factors (TFs) defining the na ïve state i... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 27, 2020 Category: Stem Cells Authors: Bingbo Shi, Dengfeng Gao, Liang Zhong, Minglei Zhi, Xiaogang Weng, Junjun Xu, Junhong Li, Xuguang Du, Yanli Xin, Jie Gao, Qianqian Zhu, Suying Cao, Zhonghua Liu and Jianyong Han Tags: Research Source Type: research
Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages
As the major interface between the body and the external environment, the skin is liable to various injuries. Skin injuries often lead to severe disability, and the exploration of promising therapeutic strateg... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 27, 2020 Category: Stem Cells Authors: Jin Liu, Xinyu Qiu, Yajie Lv, Chenxi Zheng, Yan Dong, Geng Dou, Bin Zhu, Anqi Liu, Wei Wang, Jun Zhou, Siying Liu, Shiyu Liu, Bo Gao and Yan Jin Tags: Research Source Type: research
Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts
Stem cell therapies represent a promising tool in regenerative medicine. Considering the drawbacks of direct stem cell injections (e.g. poor cell localisation), extracellular matrix-based biomaterials (e.g. sc... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 27, 2020 Category: Stem Cells Authors: H éctor Capella-Monsonís, Andrea De Pieri, Rita Peixoto, Stefanie Korntner and Dimitrios I. Zeugolis Tags: Research Source Type: research
Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells
Mesenchymal stem cell (MSC)-derived exosomes have shown comprehensive application prospects over the years. Despite performing similar functions, exosomes from different origins present heterogeneous character... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 27, 2020 Category: Stem Cells Authors: Zheng-gang Wang, Zhi-yi He, Shuang Liang, Qing Yang, Peng Cheng and An-min Chen Tags: Research Source Type: research
Transplantation of photobiomodulation-preconditioned diabetic stem cells accelerates ischemic wound healing in diabetic rats
Diabetic foot ulcer is the most costly and complex challenge for patients with diabetes. We hereby assessed the effectiveness of different preconditioned adipose-derived mesenchymal stem cells (AD-MSCs) and ph... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 25, 2020 Category: Stem Cells Authors: Houssein Ahmadi, Abdollah Amini, Fatemeh Fadaei Fathabady, Atarodsadat Mostafavinia, Fatemeh Zare, Roohollah Ebrahimpour-malekshah, Mustafa Neshat Ghalibaf, Matin Abrisham, Fatemehalsadat Rezaei, Richard Albright, Seyed Kamran Ghoreishi, Sufan Chien and M Tags: Research Source Type: research
