Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9+ cells to prevent the development of liver cancer in a mouse model
Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal. The rate of symmetric division increases as more cancer stem cells (CSCs) become malignant; however, the signa... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 12, 2021 Category: Stem Cells Authors: Mi Chen, Chenxia Lu, Hanwen Lu, Junyi Zhang, Dan Qin, Shenghui Liu, Xiaodong Li and Lisheng Zhang Tags: Research Source Type: research
GSK3 β rephosphorylation rescues ALPL deficiency-induced impairment of odontoblastic differentiation of DPSCs
Premature exfoliation of the deciduous teeth is a common manifestation in childhood patients with hypophosphatasia (HPP), which is an autosomal inherited disease caused by ALPL mutations. Dysplasia of the ceme... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2021 Category: Stem Cells Authors: Liqiang Zhang, Jiangdong Zhao, Jiayi Dong, Yuting Liu, Kun Xuan and Wenjia Liu Tags: Research Source Type: research
Adipose-derived stem cells combined with platelet-rich plasma enhance wound healing in a rat model of full-thickness skin defects
This study hypothesizes that the combination ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2021 Category: Stem Cells Authors: Xuejun Ni, Xiuying Shan, Lili Xu, Wenjun Yu, Mingliang Zhang, Chen Lei, Nating Xu, Junyu Lin and Biao Wang Tags: Research Source Type: research
Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice
Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following lo... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2021 Category: Stem Cells Authors: Oliver Treacy, Kevin Lynch, Nick Murphy, Xizhe Chen, Ellen Donohoe, Aoife Canning, Paul Lohan, Georgina Shaw, Gerry Fahy, Aideen E. Ryan and Thomas Ritter Tags: Short report Source Type: research
Secretomes of human pluripotent stem cell-derived smooth muscle cell progenitors upregulate extracellular matrix metabolism in the lower urinary tract and vagina
Adult mesenchymal stem cells (MSCs) have been studied extensively for regenerative medicine; however, they have limited proliferation in vitro, and the long culture time induces cell senescence. MSCs also cont... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2021 Category: Stem Cells Authors: Guobing Zhuang, Yan Wen, Mason Briggs, Qingchun Shao, Darlene Tran, Hongbo Wang and Bertha Chen Tags: Research Source Type: research
Mesenchymal stromal/stem cells and their exosomes for restoration of spermatogenesis in non-obstructive azoospermia: a systemic review
Stem cells have been introduced as new promising therapeutic agents in treatment of degenerative diseases because of having high differentiation potential while maintaining the ability to self-replicate and re... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 6, 2021 Category: Stem Cells Authors: Rano Zhankina, Neda Baghban, Manarbek Askarov, Dana Saipiyeva, Almaz Ibragimov, Bakhyt Kadirova, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Ulanbek Zhanbyrbekuly and Amin Tamadon Tags: Review Source Type: research
Sodium alginate-bioglass-encapsulated hAECs restore ovarian function in premature ovarian failure by stimulating angiogenic factor secretion
Human amniotic epithelial cells (hAECs) exhibit a strong capability to restore ovarian function in chemotherapy-induced premature ovarian failure (POF). However, the therapeutic efficacy of hAECs is usually af... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 1, 2021 Category: Stem Cells Authors: Yating Huang, Zhijie Ma, Xiaojun Kuang, Qiuwan Zhang, Haiyan Li and Dongmei Lai Tags: Research Source Type: research
Mesenchymal stem cells and extracellular vesicles in therapy against kidney diseases
Kidney diseases pose a threat to human health due to their rising incidence and fatality rate. In preclinical and clinical studies, it has been acknowledged that mesenchymal stem cells (MSCs) are effective and... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 31, 2021 Category: Stem Cells Authors: Yuling Huang and Lina Yang Tags: Review Source Type: research
Efficacy of topical and systemic transplantation of mesenchymal stem cells in a rat model of diabetic ischemic wounds
Mesenchymal stem cells (MSCs) exert positive effects in chronic wounds. However, critical parameters, such as the most effective administration routes, remain unclear. Accordingly, the purpose of this study wa... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 31, 2021 Category: Stem Cells Authors: Jianxin Yan, Jiaji Liang, Yingxuan Cao, Mariya M. El Akkawi, Xuan Liao, Xiaojia Chen, Chengzhi Li, Kecheng Li, Guanghui Xie and Hongwei Liu Tags: Research Source Type: research
Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR-192-5p/IL-17RA/Smad axis
Hypertrophic scar (HS) is a fibro-proliferative disorder of dermis after burn or trauma and usually leads to esthetic disfiguration and functionary impairment for patients. Emerging evidences demonstrated ADSC... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 31, 2021 Category: Stem Cells Authors: Yan Li, Jian Zhang, Jihong Shi, Kaituo Liu, Xujie Wang, Yanhui Jia, Ting He, Kuo Shen, Yunchuan Wang, Jiaqi Liu, Wei Zhang, Tongtao Wang, Zhao Zheng and Dahai Hu Tags: Research Source Type: research
Therapeutic potential of small extracellular vesicles derived from lipoma tissue in adipose tissue regeneration —an in vitro and in vivo study
To explore the adipogenic effects of the small extracellular vesicles derived from the lipoma tissues (sEV-LT), and to find a new cell-free therapeutic approach for adipose tissue regeneration. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 31, 2021 Category: Stem Cells Authors: Pengyu Hong, Xiaoyang Xu, Xin Hu, Hao Yang, Yue Wu, Juan Chen, Kun Li and Zhangui Tang Tags: Research Source Type: research
The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection
Hepatic ischaemia-reperfusion injury (HIRI) is inevitable in complicated liver surgery and is a major factor leading to postoperative complications and liver dysfunction. Studies have shown that the paracrine ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 30, 2021 Category: Stem Cells Authors: Zhihui Jiao, Yajun Ma, Qianzhen Zhang, Yue Wang, Tao Liu, Xiaoning Liu, Chenxi Piao, Boyang Liu and Hongbin Wang Tags: Research Source Type: research
The effect of bone marrow-derived mesenchymal stem cell co-transplantation with hematopoietic stem cells on liver fibrosis alleviation and survival in patients with class III β-thalassemia major
Hepatic fibrosis is a common complication in transfusion-dependent thalassemia patients. Data on the co-transplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) in beta-thalassemia... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 29, 2021 Category: Stem Cells Authors: Tahereh Rostami, Amir Kasaeian, Nasrollah Maleki, Mohsen Nikbakht, Azadeh Kiumarsi, Seyed Mohammad Tavangar, Amir Pejman Hashemi Taheri, Seied Asadollah Mousavi and Ardeshir Ghavamzadeh Tags: Research Source Type: research
Transplantation of human induced pluripotent stem cell-derived neural crest cells for corneal endothelial regeneration
The corneal endothelium maintains corneal hydration through the barrier and pump function, while its dysfunction may cause corneal edema and vision reduction. Considering its development from neural crest cell... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 29, 2021 Category: Stem Cells Authors: Yajie Gong, Haoyun Duan, Xin Wang, Can Zhao, Wenjing Li, Chunxiao Dong, Zongyi Li and Qingjun Zhou Tags: Research Source Type: research
miR-133a silencing rescues glucocorticoid-induced bone loss by regulating the MAPK/ERK signaling pathway
Dysfunction of mesenchymal stem cells (MSCs) is recognized as critical to the pathogenesis of glucocorticoid-induced osteoporosis (GIO), suggesting the potential of MSC-targeting interventions for this disorde... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 29, 2021 Category: Stem Cells Authors: Gang Wang, Fengbin Wang, Lecheng Zhang, Chao Yan and Yuelei Zhang Tags: Research Source Type: research
