Human placental mesenchymal stem cells ameliorate chemotherapy-induced damage in the testis by reducing apoptosis/oxidative stress and promoting autophagy
The side effects of busulfan on male reproduction are serious, so fertility preservation in children undergoing busulfan treatment is a major worldwide concern. Human placental mesenchymal stem cells (hPMSCs) ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 20, 2021 Category: Stem Cells Authors: Jiafeng Lu, Zhenxing Liu, Mingkai Shu, Liya Zhang, Wenjuan Xia, Liuna Tang, Jincheng Li, Boxian Huang and Hong Li Tags: Research Source Type: research
Adipose-derived mesenchymal stem cells attenuate dialysis-induced peritoneal fibrosis by modulating macrophage polarization via interleukin-6
Life-long peritoneal dialysis (PD) as a renal replacement therapy is limited by peritoneal fibrosis. Previous studies showed immunomodulatory and antifibrotic effects of adipose-derived mesenchymal stem cells ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 19, 2021 Category: Stem Cells Authors: Chih-Yu Yang, Pu-Yuan Chang, Jun-Yi Chen, Bo-Sheng Wu, An-Hang Yang and Oscar Kuang-Sheng Lee Tags: Research Source Type: research
Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency
While therapeutic success of the limbal tissue or cell transplantation to treat severe cases of limbal stem cell (LSC) deficiency (LSCD) strongly depends on the percentage of LSCs within the transplanted cells... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 19, 2021 Category: Stem Cells Authors: Alexandra Norrick, Jasmina Esterlechner, Elke Niebergall-Roth, Ulf Dehio, Samar Sadeghi, Hannes M. Schr öder, Seda Ballikaya, Nicole Stemler, Christoph Ganss, Kathrin Dieter, Ann-Kathrin Dachtler, Patrick Merz, Saadettin Sel, James Chodosh, Claus Cursief Tags: Research Source Type: research
Alterations of mesenchymal stromal cells in cerebrospinal fluid: insights from transcriptomics and an ALS clinical trial
Mesenchymal stromal cells (MSCs) have been studied with increasing intensity as clinicians and researchers strive to understand the ability of MSCs to modulate disease progression and promote tissue regenerati... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 18, 2021 Category: Stem Cells Authors: Ashley A. Krull, Deborah O. Setter, Tania F. Gendron, Sybil C. L. Hrstka, Michael J. Polzin, Joseph Hart, Amel Dudakovic, Nicolas N. Madigan, Allan B. Dietz, Anthony J. Windebank, Andre J. van Wijnen and Nathan P. Staff Tags: Research Source Type: research
Online marketing practices of regenerative medicine clinics in US-Mexico border region: a web surveillance study
The potential of regenerative medicine to improve human health has led to the rapid expansion of stem cell clinics throughout the world with varying levels of regulation and oversight. This has led to a market... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 18, 2021 Category: Stem Cells Authors: Javier Chavez, Neal A. Shah, Severin Ruoss, Raphael E. Cuomo, Samuel R. Ward and Tim K. Mackey Tags: Research Source Type: research
GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line
Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 18, 2021 Category: Stem Cells Authors: Mika J. V älimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku Varjosalo, Merja Heinäniemi, Bogac L. Kaynak and Heikki Ruskoaho Tags: Research Source Type: research
Repair abilities of mouse autologous adipose-derived stem cells and ShakeGel ™3D complex local injection with intrauterine adhesion by BMP7-Smad5 signaling pathway activation
The objective was to explore the therapeutic effect of autologous adipose-derived stem cells (ADSCs) combined with ShakeGel ™3D transplantation to activate the BMP7-Smad5 signaling pathway to treat intrauterine... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 18, 2021 Category: Stem Cells Authors: Yun-xia Zhao, Shao-rong Chen, Qiao-yi Huang, Wei-can Chen, Tian Xia, Yan-chuan Shi, Hong-zhi Gao, Qi-yang Shi and Shu Lin Tags: Research Source Type: research
Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical applications have received much attention from the global scientific community in an increasing manner. Firstly, MSCs wer... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 18, 2021 Category: Stem Cells Authors: Alexander Markov, Lakshmi Thangavelu, Surendar Aravindhan, Angelina Olegovna Zekiy, Mostafa Jarahian, Max Stanley Chartrand, Yashwant Pathak, Faroogh Marofi, Somayeh Shamlou and Ali Hassanzadeh Tags: Review Source Type: research
Secreted factors from dental pulp stem cells improve Sj ögren’s syndrome via regulatory T cell-mediated immunosuppression
Sj ögren’s syndrome (SS) is a chronic autoimmune disease primarily characterized by inflammation in the salivary and lacrimal glands. Activated T cells contribute to disease pathogenesis by producing proinflamm... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 16, 2021 Category: Stem Cells Authors: Mayu Matsumura-Kawashima, Kenichi Ogata, Masafumi Moriyama, Yuka Murakami, Tatsuya Kawado and Seiji Nakamura Tags: Research Source Type: research
Analyses of the pericyte transcriptome in ischemic skeletal muscles
Peripheral arterial disease (PAD) affects millions of people and compromises quality of life. Critical limb ischemia (CLI), which is the most advanced stage of PAD, can cause nonhealing ulcers and strong chron... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 16, 2021 Category: Stem Cells Authors: Yuan-chi Teng, Alfredo Leonardo Porf írio-Sousa, Giulia Magri Ribeiro, Marcela Corso Arend, Lindolfo da Silva Meirelles, Elizabeth Suchi Chen, Daniela Santoro Rosa and Sang Won Han Tags: Research Source Type: research
Gene engineered mesenchymal stem cells: greater transgene expression and efficacy with minicircle vs. plasmid DNA vectors in a mouse model of acute lung injury
Acute lung injury (ALI) and in its severe form, acute respiratory distress syndrome (ARDS), results in increased pulmonary vascular inflammation and permeability and is a major cause of mortality in many criti... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 16, 2021 Category: Stem Cells Authors: Maria Florian, Jia-Pey Wang, Yupu Deng, Luciana Souza-Moreira, Duncan J. Stewart and Shirley H. J. Mei Tags: Research Source Type: research
Apoptosis repressor with caspase recruitment domain (ARC) promotes bone regeneration of bone marrow-derived mesenchymal stem cells by activating Fgf-2/PI3K/Akt signaling
This study aims to investigate whether apoptosis repressor with caspase recruitment domain (ARC) could promote survival and enhance osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMS... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 16, 2021 Category: Stem Cells Authors: Longwei Hu, Yang Wang, Hongya Pan, Kathreena Kadir, Jin Wen, Siyi Li and Chenping Zhang Tags: Research Source Type: research
EIF5A2 enhances stemness of epithelial ovarian cancer cells via a E2F1/KLF4 axis
Ovarian cancer stem cells (OCSC), endowed with tumor-initiating and self-renewal capacity, would account not only for the tumor growth, the peritoneal metastasis, and the relapse, but also for the acquisition ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 16, 2021 Category: Stem Cells Authors: Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang and Xingsheng Yang Tags: Research Source Type: research
Therapeutic effects of peripherally administrated neural crest stem cells on pain and spinal cord changes after sciatic nerve transection
Severe peripheral nerve injury significantly affects patients ’ quality of life and induces neuropathic pain. Neural crest stem cells (NCSCs) exhibit several attractive characteristics for cell-based therapies ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 15, 2021 Category: Stem Cells Authors: Yang Zhang, Xiang Xu, Yuxin Tong, Xijie Zhou, Jian Du, In Young Choi, Shouwei Yue, Gabsang Lee, Blake N. Johnson and Xiaofeng Jia Tags: Research Source Type: research
Extracellular vesicles derived from EphB2-overexpressing bone marrow mesenchymal stem cells ameliorate DSS-induced colitis by modulating immune balance
The bone marrow mesenchymal stem cell (BMSCs)-derived extracellular vesicles (EVs) open up a new avenue for ulcerative colitis (UC) treatment recently, but they are not selectively enriched in targeted tissues... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 15, 2021 Category: Stem Cells Authors: Ting Yu, Si Chu, Xingxing Liu, Junyi Li, Qianyun Chen, Meng Xu, Hui Wu, Mingyue Li, Yalan Dong, Feng Zhu, Haifeng Zhou, Desheng Hu and Heng Fan Tags: Research Source Type: research
