Morusin induces osteogenic differentiation of bone marrow mesenchymal stem cells by canonical Wnt/ β-catenin pathway and prevents bone loss in an ovariectomized rat model
Osteoporosis (OP) is a metabolic bone disease due to the imbalance of osteogenesis and bone resorption, in which, bone marrow mesenchymal stem cells (BMSCs) have a significant effect as the seed cells. Recent ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 12, 2021 Category: Stem Cells Authors: Ming Chen, Hui Han, Siqi Zhou, Yinxian Wen and Liaobin Chen Tags: Research Source Type: research
Reprogrammed mesenchymal stem cells derived from iPSCs promote bone repair in steroid-associated osteonecrosis of the femoral head
Cellular therapy based on mesenchymal stem cells (MSCs) is a promising novel therapeutic strategy for the osteonecrosis of the femoral head (ONFH), which is gradually becoming popular, particularly for early-s... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 12, 2021 Category: Stem Cells Authors: Meiling Zhou, Jiaoya Xi, Yaofeng Cheng, Denglong Sun, Peng Shu, Shuiqing Chi, Shuo Tian and Shunan Ye Tags: Research Source Type: research
Lnc13728 facilitates human mesenchymal stem cell adipogenic differentiation via positive regulation of ZBED3 and downregulation of the WNT/ β-catenin pathway
Obesity has received increasing attention because of its widespread worldwide occurrence and many threats to health. Human adipose-derived mesenchymal stem cells (hADSCs) are a critical source of adipocytes. L... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 12, 2021 Category: Stem Cells Authors: Haoying Xu, Yanlei Yang, Linyuan Fan, Luchan Deng, Junfen Fan, Di Li, Hongling Li and Robert Chunhua Zhao Tags: Research Source Type: research
Concentrated exosomes from menstrual blood-derived stromal cells improves ovarian activity in a rat model of premature ovarian insufficiency
Premature ovarian insufficiency (POI) is one of the major causes of infertility. We previously demonstrated that transplantation of menstrual blood-derived stromal cells (MenSCs) effectively improved ovarian f... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 12, 2021 Category: Stem Cells Authors: Siwen Zhang, Boxian Huang, Peng Su, Qiyuan Chang, Pingping Li, Aixin Song, Xinyang Zhao, Zhengwei Yuan and Jichun Tan Tags: Research Source Type: research
Will mesenchymal stem cells be future directions for treating radiation-induced skin injury?
Radiation-induced skin injury (RISI) is one of the common serious side effects of radiotherapy (RT) for patients with malignant tumors. Mesenchymal stem cells (MSCs) are applied to RISI repair in some clinical... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 12, 2021 Category: Stem Cells Authors: Zhuoqun Fang, Penghong Chen, Shijie Tang, Aizhen Chen, Chaoyu Zhang, Guohao Peng, Ming Li and Xiaosong Chen Tags: Review Source Type: research
hiPSC-derived NSCs effectively promote the functional recovery of acute spinal cord injury in mice
Spinal cord injury (SCI) is a common disease that results in motor and sensory disorders and even lifelong paralysis. The transplantation of stem cells, such as embryonic stem cells (ESCs), induced pluripotent... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 11, 2021 Category: Stem Cells Authors: Desheng Kong, Baofeng Feng, Asiamah Ernest Amponsah, Jingjing He, Ruiyun Guo, Boxin Liu, Xiaofeng Du, Xin Liu, Shuhan Zhang, Fei Lv, Jun Ma and Huixian Cui Tags: Research Source Type: research
Mitochondrial activity regulates the differentiation of skin-derived mesenchymal stem cells into brown adipocytes to contribute to hypertension
Brown adipocytes (BAs) are major components of brown adipose tissue (BAT), which is involved in blood pressure regulation. BAs are derived from multiple progenitors, including PDGFR α+ adipose-derived stem cells (... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 10, 2021 Category: Stem Cells Authors: Wenda Xi, Wendong Chen, Weihong Sun, Xiangxiao Li, Zhimin Suo, Gonghao Jiang, Pingjin Gao and Qun Li Tags: Research Source Type: research
Migration of pre-induced human peripheral blood mononuclear cells from the transplanted to contralateral eye in mice
Retina diseases may lead to blindness as they often afflict both eyes. Stem cell transplantation into the affected eye(s) is a promising therapeutic strategy for certain retinal diseases. Human peripheral bloo... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 10, 2021 Category: Stem Cells Authors: Jianfa Huang, Bikun Xian, Yuting Peng, Baozhu Zeng, Weihua Li, Zhiquan Li, Yaojue Xie, Minglei Zhao, Hening Zhang, Minyi Zhou, Huan Yu, Peixin Wu, Xing Liu and Bing Huang Tags: Research Source Type: research
Transcriptional factor FoxM1-activated microRNA-335-3p maintains the self-renewal of neural stem cells by inhibiting p53 signaling pathway via Fmr1
New mechanistic insights into the self-renewal ability and multipotent properties of neural stem cells (NSCs) are currently under active investigation for potential use in the treatment of neurological disease... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 10, 2021 Category: Stem Cells Authors: Jiaoying Jia, Yan Cui, Zhigang Tan, Min Liu and Yugang Jiang Tags: Research Source Type: research
mTOR inhibitor INK128 promotes wound healing by regulating MDSCs
Skin wounds in diabetic patients hardly recover. Accumulating evidence has shown that mammalian target of rapamycin (mTOR) pathway and myeloid-derived suppressor cells (MDSCs) are involved in inflammatory-rela... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 10, 2021 Category: Stem Cells Authors: Yi Li, Yujun Xu, Xinhan Liu, Xin Yan, Yue Lin, Qian Tan and Yayi Hou Tags: Research Source Type: research
Regulation of connective tissue growth factor expression by miR-133b for the treatment of renal interstitial fibrosis in aged mice with unilateral ureteral obstruction
Renal interstitial fibrosis, an important pathological feature of kidney aging and chronic renal failure, is regulated by mesenchymal stem cells (MSCs). We have previously demonstrated low expression of miR-13... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 10, 2021 Category: Stem Cells Authors: Dan Cao, Yuan Wang, Yingjie Zhang, Yinping Zhang, Qi Huang, Zhong Yin, Guangyan Cai, Xiangmei Chen and Xuefeng Sun Tags: Research Source Type: research
MSCs derived from amniotic fluid and umbilical cord require different administration schemes and exert different curative effects on different tissues in rats with CLP-induced sepsis
Mesenchymal stem cells (MSCs) are derived from multiple tissues, including amniotic fluid (AF-MSCs) and the umbilical cord (UC-MSCs). Although the therapeutic effect of MSCs on sepsis is already known, researc... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 6, 2021 Category: Stem Cells Authors: Rui Chen, Yingjun Xie, Xuan Zhong, Fei Chen, Yu Gong, Na Wang and Ding Wang Tags: Research Source Type: research
Effect of fibronectin, FGF-2, and BMP4 in the stemness maintenance of BMSCs and the metabolic and proteomic cues involved
Growing evidence suggests that the pluripotent state of mesenchymal stem cells (MSCs) relies on specific local microenvironmental cues such as adhesion molecules and growth factors. Fibronectin (FN), fibroblas... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 6, 2021 Category: Stem Cells Authors: Lingling Chen, Morgan Carlton, Xiaodan Chen, Navdeep Kaur, Hollie Ryan, Tony J Parker, Zhengmei Lin, Yin Xiao and Yinghong Zhou Tags: Research Source Type: research
The CAD risk locus 9p21 increases the risk of vascular calcification in an iPSC-derived VSMC model
Coronary artery disease (CAD) is the leading cause of death worldwide. Chromosome locus 9p21 was the first to be associated with increased risk of CAD and coronary artery calcification (CAC). Vascular calcific... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 6, 2021 Category: Stem Cells Authors: Anja Trillhaase, Beatrice Schmidt, Marlon M ärtens, Undine Haferkamp, Jeanette Erdmann and Zouhair Aherrahrou Tags: Research Source Type: research
Anti-apoptotic effect of adipose tissue-derived stromal vascular fraction in denervated rat muscle
Recovery of muscle function after peripheral nerve injury is often poor, and this can be attributed to muscle fiber atrophy and cell death. In the current study, we have investigated the effects of stromal vas... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 4, 2021 Category: Stem Cells Authors: R. El-Habta, G. Andersson, P. J. Kingham and L. J. Backman Tags: Research Source Type: research
