microRNA-186 in extracellular vesicles from bone marrow mesenchymal stem cells alleviates idiopathic pulmonary fibrosis via interaction with SOX4 and DKK1
Previous reports have identified that human bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) with their cargo microRNAs (miRNAs) are a promising therapeutic approach for the treatmen... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 3, 2021 Category: Stem Cells Authors: Jing Zhou, Yang Lin, Xiuhua Kang, Zhicheng Liu, Wei Zhang and Fei Xu Tags: Research Source Type: research
MSI-1436 improves EMS adipose derived progenitor stem cells in the course of adipogenic differentiation through modulation of ER stress, apoptosis, and oxidative stress
Protein tyrosine phosphatase 1B (PTP1B) is one of the major negative regulators of leptin and insulin signaling, and has been strongly implicated in insulin resistance development in the course of obesity and ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 3, 2021 Category: Stem Cells Authors: Lynda Bourebaba, Katarzyna Kornicka-Garbowska, Mohamad Al Naem, Michael R öcken, Jacek Łyczko and Krzysztof Marycz Tags: Research Source Type: research
Dynamic proteomic profiling of human periodontal ligament stem cells during osteogenic differentiation
Human periodontal ligament stem cells (hPDLSCs) are ideal seed cells for periodontal regeneration. A greater understanding of the dynamic protein profiles during osteogenic differentiation contributed to the i... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 3, 2021 Category: Stem Cells Authors: Jianjia Li, Zhifa Wang, Xiangyu Huang, Zhaodan Wang, Zehao Chen, Runting Wang, Zhao Chen, Wei Liu, Buling Wu, Fuchun Fang and Wei Qiu Tags: Research Source Type: research
The effect of endothelial progenitor cell transplantation on neointimal hyperplasia and reendothelialisation after balloon catheter injury in rat carotid arteries
Reendothelialisation is the natural pathway that inhibits neointimal hyperplasia and in-stent restenosis. Circulating endothelial progenitor cells (EPCs) derived from bone marrow (BM) might contribute to endot... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 3, 2021 Category: Stem Cells Authors: Wei Wang, Yingqian Zhang, Hui Hui, Wei Tong, Zechen Wei, Zhongxuan Li, Suhui Zhang, Xin Yang, Jie Tian and Yundai Chen Tags: Research Source Type: research
Electrospun fibers enhanced the paracrine signaling of mesenchymal stem cells for cartilage regeneration
Secretome profiles of mesenchymal stem cells (MSCs) are reflective of their local microenvironments. These biologically active factors exert an impact on the surrounding cells, eliciting regenerative responses... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 3, 2021 Category: Stem Cells Authors: Nurul Dinah Kadir, Zheng Yang, Afizah Hassan, Vinitha Denslin and Eng Hin Lee Tags: Research Source Type: research
Lung organoids, useful tools for investigating epithelial repair after lung injury
Organoids are derived from stem cells or organ-specific progenitors. They display structures and functions consistent with organs in vivo. Multiple types of organoids, including lung organoids, can be generate... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 30, 2021 Category: Stem Cells Authors: Jing Kong, Shiyuan Wen, Wenjing Cao, Peng Yue, Xin Xu, Yu Zhang, Lisha Luo, Taigui Chen, Lianbao Li, Feng Wang, Jian Tao, Guozhong Zhou, Suyi Luo, Aihua Liu and Fukai Bao Tags: Review Source Type: research
Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series
Acute respiratory distress syndrome (ARDS) is a fatal complication of coronavirus disease 2019 (COVID-19). There are a few reports of allogeneic human mesenchymal stem cells (MSCs) as a potential treatment for... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 29, 2021 Category: Stem Cells Authors: Seyed-Mohammad Reza Hashemian, Rasoul Aliannejad, Morteza Zarrabi, Masoud Soleimani, Massoud Vosough, Seyedeh-Esmat Hosseini, Hamed Hossieni, Saeid Heidari Keshel, Zeinab Naderpour, Ensiyeh Hajizadeh-Saffar, Elham Shajareh, Hamidreza Jamaati, Mina Soufi-Z Tags: Research Source Type: research
Generation of dyskeratosis congenita-like hematopoietic stem cells through the stable inhibition of DKC1
Dyskeratosis congenita (DC) is a rare telomere biology disorder, which results in different clinical manifestations, including severe bone marrow failure. To date, the only curative treatment for the bone marr... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 29, 2021 Category: Stem Cells Authors: Carlos Carrascoso-Rubio, Hidde A. Zittersteijn, Laura Pintado-Berninches, Beatriz Fern ández-Varas, M. Luz Lozano, Cristina Manguan-Garcia, Leandro Sastre, Juan A. Bueren, Rosario Perona and Guillermo Guenechea Tags: Short report Source Type: research
Clinical Translation of Cell Therapies in Stroke (CT2S) Checklist —a pragmatic tool to accelerate development of cell therapy products
Cell therapies present an exciting potential but there is a long history of expensive translational failures in stroke research. Researchers engaged in cell therapy research would benefit from a practical fram... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 29, 2021 Category: Stem Cells Authors: Anjali Nagpal, Austin G. Milton, Simon A. Koblar and M. Anne Hamilton-Bruce Tags: Method Source Type: research
Adipose-derived cellular therapies prolong graft survival in an allogenic hind limb transplantation model
The long-term survival after vascularized composite allotransplantation (VCA) is often limited by systemic rejection as well as the adverse effects of immunosuppressants. The stromal vascular fraction (SVF) ca... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 29, 2021 Category: Stem Cells Authors: Jingting Chen, Yinmin Wang, Haoyue Hu, Yao Xiong, Shoubao Wang and Jun Yang Tags: Research Source Type: research
Myocardial ischemia reperfusion injury is alleviated by curcumin-peptide hydrogel via upregulating autophagy and protecting mitochondrial function
Ischemia-reperfusion injury (IRI) is an important factor limiting the success of cardiac reperfusion therapy. Curcumin has a significant cardioprotective effect against IRI, can inhibit ventricular remodeling ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 28, 2021 Category: Stem Cells Authors: Chi-Lin Liao, Yang Liu, Meng-Zhao Huang, Hua-Yong Liu, Zi-Liang Ye and Qiang Su Tags: Research Source Type: research
Requirement of splicing factor hnRNP A2B1 for tumorigenesis of melanoma stem cells
Cancer stem cells play essential roles in tumorigenesis, thus forming an important target for tumor therapy. The hnRNP family proteins are important splicing factors that have been found to be associated with ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 28, 2021 Category: Stem Cells Authors: Mengqi Chu, Haitao Wan and Xiaobo Zhang Tags: Research Source Type: research
Akt signaling is activated by TGF β2 and impacts tenogenic induction of mesenchymal stem cells
Tissue engineered and regenerative approaches for treating tendon injuries are challenged by the limited information on the cellular signaling pathways driving tenogenic differentiation of stem cells. Members ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 26, 2021 Category: Stem Cells Authors: Sophia K. Theodossiou, Jett B. Murray, LeeAnn A. Hold, Jeff M. Courtright, Anne M. Carper and Nathan R. Schiele Tags: Research Source Type: research
Improvement of sensory neuron growth and survival via negatively regulating PTEN by miR-21-5p-contained small extracellular vesicles from skin precursor-derived Schwann cells
Patients with peripheral nerve injury (PNI) often suffer from hypoxic ischemic impairments, in particular when combined with vascular damage, causing neuronal dysfunction and death. Increasing attention has be... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 25, 2021 Category: Stem Cells Authors: Meng Cong, Mi Shen, Xia Wu, Yan Li, Liting Wang, Qianru He, Haiyan Shi and Fei Ding Tags: Research Source Type: research
CAR T cells in solid tumors: challenges and opportunities
CARs are simulated receptors containing an extracellular single-chain variable fragment (scFv), a transmembrane domain, as well as an intracellular region of immunoreceptor tyrosine-based activation motifs (IT... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 25, 2021 Category: Stem Cells Authors: Faroogh Marofi, Roza Motavalli, Vladimir A. Safonov, Lakshmi Thangavelu, Alexei Valerievich Yumashev, Markov Alexander, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Mostafa Jarahian, Sepideh Izadi, Ali Hassanzadeh, Naghmeh Shirafkan, Safa Tahmas Tags: Review Source Type: research
