ER stress arm XBP1s plays a pivotal role in proteasome inhibition-induced bone formation

Bone destruction is a hallmark of multiple myeloma (MM). It has been reported that proteasome inhibitors (PIs) can reduce bone resorption and increase bone formation in MM patients, but the underlying mechanis...

Source: Stem Cell Research and Therapy - November 30, 2020 Category: Stem Cells Authors: Dan Zhang, Kim De Veirman, Rong Fan, Qiang Jian, Yuchen Zhang, Li Lei, Holly Evans, Yanmeng Wang, Lei Lei, Baiyan Wang, Ramone A. Williamson, Andrew Chantry, Pengcheng He, Ang Li, Hendrik De Raeve, Karin Vanderkerken & hellip; Tags: Research Source Type: research