PET/MRI Hybrid Systems
Over the last decade, the combination of PET and MRI in one system has proven to be highly successful in basic preclinical research, as well as in clinical research. Nowadays, PET/MRI systems are well established in preclinical imaging and are progressing into clinical applications to provide further insights into specific diseases, therapeutic assessments, and biological pathways. Certain challenges in terms of hardware had to be resolved concurrently with the development of new techniques to be able to reach the full potential of both combined techniques. (Source: Seminars in Nuclear Medicine)
Source: Seminars in Nuclear Medicine - April 10, 2018 Category: Nuclear Medicine Authors: Julia G. Mannheim, Andreas M. Schmid, Johannes Schwenck, Prateek Katiyar, Kristina Herfert, Bernd J. Pichler, Jonathan A. Disselhorst Source Type: research
PET/MRI in Infection and Inflammation
Hybrid positron emission tomography/magnetic resonance imaging (PET/MR) systems are now more and more available for clinical use. PET/MR combines the unique features of MR including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as well as MR spectroscopy with the quantitative physiologic information that is provided by PET. Most of the evidence of the potential clinical utility of PET/MRI is available for neuroimaging. (Source: Seminars in Nuclear Medicine)
Source: Seminars in Nuclear Medicine - April 5, 2018 Category: Nuclear Medicine Authors: Martina Sollini, Raffaella Berchiolli, Margarita Kirienko, Alexia Rossi, A.W.J.M. Glaudemans, Riemer Slart, Paola Anna Erba Source Type: research
Radiation Imagers for Quantitative, Single-particle Digital Autoradiography of Alpha- and Beta-particle Emitters
Promising therapies are being developed or are in early-stage clinical trials that employ the use of alpha- and beta-emitting radionuclides to cure hematologic malignancies. However, these targeted radionuclide therapies have not yet met their expected potential for cancer treatment. A primary reason is lack of biodistribution, dosimetry, and dose-response information at cellular levels, which are directly related to optimal targeting, achieving a requisite therapeutic dose, and assessing the safety profile in normal organs and tissues. (Source: Seminars in Nuclear Medicine)
Source: Seminars in Nuclear Medicine - March 22, 2018 Category: Nuclear Medicine Authors: Brian W. Miller Source Type: research
Absolute Quantitation of SPECT Studies
Methods for absolute quantitation of SPECT images provide an estimate of the activity uptakes in various organs and tissues in units of (M)Bq or (m)Ci. However, because tomographic SPECT images generally are hampered by several physical and camera-specific effects, accurate and precise compensation methods are required. The most important effects are (1) photon attenuation in the patient resulting in a reduction of expected acquired count; (2) the contribution of events from photons, scattered in the phantom and the collimator but accepted by the energy window because of a poor energy resolution of the NaI(Tl) crystal; and...
Source: Seminars in Nuclear Medicine - March 19, 2018 Category: Nuclear Medicine Authors: Michael Ljungberg Source Type: research
Innovations in Nuclear Imaging Instrumentation: Cerenkov Imaging
Cerenkov luminescence (CL) is blue glow light produced by charged subatomic particles travelling faster than the phase velocity of light in a dielectric medium such as water or tissue. CL was first discovered in 1934, but for biomedical research it was recognized only in 2009 after advances in optical camera sensors brought the required high sensitivity. Recently, applications of CL from clinical radionuclides have been rapidly expanding to include not only preclinical and clinical biomedical imaging but also an approach to therapy. (Source: Seminars in Nuclear Medicine)
Source: Seminars in Nuclear Medicine - March 16, 2018 Category: Nuclear Medicine Authors: Ryo Tamura, Edwin C. Pratt, Jan Grimm Source Type: research
SNMMI Procedure Standard/EANM Practice Guideline for Diuretic Renal Scintigraphy in Adults With Suspected Upper Urinary Tract Obstruction 1.0
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and professional organization founded in 1954 to promote the science, technology, and practical application of nuclear medicine. Its 18,000 members are physicians, technologists, and scientists specializing in the research and practice of nuclear medicine. In addition to publishing journals, newsletters, and books, the SNMMI also sponsors international meetings and workshops designed to increase the competencies of nuclear medicine practitioners and to promote new advances in the science of nuclear medicine. (Source: Seminars in Nuclear Medicine)
Source: Seminars in Nuclear Medicine - March 16, 2018 Category: Nuclear Medicine Authors: Andrew T. Taylor, David C. Brandon, Diego de Palma, M. Donald Blaufox, Emmanuel Durand, Belkis Erbas, Sandra F. Grant, Andrew J.W. Hilson, Anni Morsing Source Type: research
Innovations in Nuclear Imaging Instrumentation: Cerenkov Imaging
Cerenkov luminescence (CL) is blue glow light produced by charged subatomic particles travelling faster than the phase velocity of light in a dielectric medium such as water or tissue. CL was first discovered in 1934, but for biomedical research it was recognized only in 2009 after advances in optical camera sensors brought the required high sensitivity. Recently, applications of CL from clinical radionuclides have been rapidly expanding to include not only preclinical and clinical biomedical imaging but also an approach to therapy. (Source: Seminars in Nuclear Medicine)
Source: Seminars in Nuclear Medicine - March 16, 2018 Category: Nuclear Medicine Authors: Ryo Tamura, Edwin C. Pratt, Jan Grimm Source Type: research
SNMMI Procedure Standard/EANM Practice Guideline for Diuretic Renal Scintigraphy in Adults With Suspected Upper Urinary Tract Obstruction 1.0
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and professional organization founded in 1954 to promote the science, technology, and practical application of nuclear medicine. Its 18,000 members are physicians, technologists, and scientists specializing in the research and practice of nuclear medicine. In addition to publishing journals, newsletters, and books, the SNMMI also sponsors international meetings and workshops designed to increase the competencies of nuclear medicine practitioners and to promote new advances in the science of nuclear medicine. (Source: Seminars in Nuclear Medicine)
Source: Seminars in Nuclear Medicine - March 16, 2018 Category: Nuclear Medicine Authors: Andrew T. Taylor, David C. Brandon, Diego de Palma, M. Donald Blaufox, Emmanuel Durand, Belkis Erbas, Sandra F. Grant, Andrew J.W. Hilson, Anni Morsing Source Type: research
Innovations in Instrumentation for Positron Emission Tomography
PET scanners are sophisticated and highly sensitive biomedical imaging devices that can produce highly quantitative images showing the 3-dimensional distribution of radiotracers inside the body. PET scanners are commonly integrated with x-ray CT or MRI scanners in hybrid devices that can provide both molecular imaging (PET) and anatomical imaging (CT or MRI). Despite decades of development, significant opportunities still exist to make major improvements in the performance of PET systems for a variety of clinical and research tasks. (Source: Seminars in Nuclear Medicine)
Source: Seminars in Nuclear Medicine - March 12, 2018 Category: Nuclear Medicine Authors: Eric Berg, Simon R. Cherry Source Type: research
The “3M” Approach to Cardiovascular Infections: Multimodality, Multitracers, and Multidisciplinary
Cardiovascular infections are associated with high morbidity and mortality. Early diagnosis is crucial for adequate patient management, as early treatment improves the prognosis. The diagnosis cannot be made on the basis of a single symptom, sign, or diagnostic test. Rather, the diagnosis requires a multidisciplinary discussion in addition to the integration of clinical signs, microbiology data, and imaging data. The application of multimodality imaging, including molecular imaging techniques, has improved the sensitivity to detect infections involving heart valves and vessels and implanted cardiovascular devices while als...
Source: Seminars in Nuclear Medicine - March 9, 2018 Category: Nuclear Medicine Authors: Martina Sollini, Raffaella Berchiolli, Roberto C. Delgado Bolton, Alexia Rossi, Margarita Kirienko, Roberto Boni, Elena Lazzeri, Riemer Slart, Paola Anna Erba Source Type: research
Molecular Imaging of Vulnerable Plaque
Molecular imaging provides multiple imaging techniques to identify characteristics of vulnerable plaque including I) Inflammatory cells (the presence and metabolic activity of macrophages), II) synthesis of lipid and fatty acid in the plaque, III) the presence of hypoxia in severely inflamed lesions, IV) expression of factors stimulating angiogenesis, V) expression of protease enzymes in the lesion, VI) development of microthrombi in late-phase lesions, VII) apoptosis, and VIII) microcalcification. (Source: Seminars in Nuclear Medicine)
Source: Seminars in Nuclear Medicine - March 9, 2018 Category: Nuclear Medicine Authors: Takehiro Nakahara, Jagat Narula, H. William Strauss Source Type: research
