Clarithromycin suppresses IL-13-induced goblet cell metaplasia via the TMEM16A-dependent pathway in guinea pig airway epithelial cells
ConclusionsCAM inhibited IL-13-induced TMEM16A expression, Cl ion transport and goblet cell metaplasia both in vitro and in vivo. CAM may thus improve airway mucociliary differentiation by attenuating TMEM16A expression in IL-13-related asthma. (Source: Respiratory Investigation)
Source: Respiratory Investigation - November 3, 2018 Category: Respiratory Medicine Source Type: research
Baloxavir heralds a new era in influenza virus biology
Publication date: Available online 3 November 2018Source: Respiratory InvestigationAuthor(s): Toshiaki Kikuchi, Akira WatanabeAbstractBaloxavir marboxil is an orally available prodrug of baloxavir acid. Japan was the first country to approve baloxavir marboxil as a treatment for influenza. The antiviral mechanism of action of baloxavir is unique; the drug blocks initiation of viral mRNA synthesis, thus preventing proliferation of the influenza virus. A single oral dose of baloxavir is usually well tolerated; it hastens alleviation of influenza symptoms and shortens the duration of viral shedding. However, novel influenza v...
Source: Respiratory Investigation - November 3, 2018 Category: Respiratory Medicine Source Type: research
Editorial Board
Publication date: November 2018Source: Respiratory Investigation, Volume 56, Issue 6Author(s): (Source: Respiratory Investigation)
Source: Respiratory Investigation - October 31, 2018 Category: Respiratory Medicine Source Type: research
Quantitative measurement of airway dimensions using ultra-high resolution computed tomography
ConclusionsThe ultra-high resolution scan may allow more accurate measurement of the bronchioles with smaller dimensions compared with the conventional scan. (Source: Respiratory Investigation)
Source: Respiratory Investigation - October 25, 2018 Category: Respiratory Medicine Source Type: research
Factors affecting bacterial culture positivity in specimens from bronchoscopy in patients with suspected lung cancer
ConclusionBecause of the low prevalence of positive bacterial cultures in patients with suspected lung cancer, bacterial culture may be limited to specific patients, such as those with calcifications. Lesions with cavitation warrant close monitoring. (Source: Respiratory Investigation)
Source: Respiratory Investigation - October 25, 2018 Category: Respiratory Medicine Source Type: research
