Variation in interferon-γ production between QFT-Plus and QFT-GIT assays in TB contact investigation
ConclusionsQFT-Plus revealed significantly higher positivity rate compared with QFT-GIT, which might be attributed to increased IFN-γ production. The cut-off in both QFT-Plus and QFT-GIT was 0.35 IU/mL. These effects might resulted in the higher positivity rate in QFT-Plus. (Source: Respiratory Investigation)
Source: Respiratory Investigation - August 10, 2019 Category: Respiratory Medicine Source Type: research
Summary of the Japanese Respiratory Society statement for the treatment of lung cancer with comorbid interstitial pneumonia
Publication date: Available online 1 August 2019Source: Respiratory InvestigationAuthor(s): Takashi Ogura, Nagio Takigawa, Keisuke Tomii, Kazuma Kishi, Yoshikazu Inoue, Eiki Ichihara, Sakae Homma, Kazuhisa Takahashi, Hiroaki Akamatsu, Satoshi Ikeda, Naohiko Inase, Tae Iwasawa, Yuichiro Ohe, Hiromitsu Ohta, Hiroshi Onishi, Isamu Okamoto, Kazumasa Ogawa, Kazuo Kasahara, Hiroki Karata, Takumi KishimotoAbstractDramatic progress in targeted therapy and immunotherapy has been changing clinical practices in lung cancer. With the accumulation of clinical practice, it has become clear that pre-existing interstitial pneumonia (IP) c...
Source: Respiratory Investigation - August 1, 2019 Category: Respiratory Medicine Source Type: research
Probe-based optical fiberscopy for the direct observation of peripheral pulmonary lesions
ConclusionsThese results suggest that the findings of direct observation using probe-based optical fiberscopy are useful for differentiating malignant from benign peripheral pulmonary lesions.Trial registryUMIN-CTR; UMIN000018796; URL: https://www.umin.ac.jp/ctr/index.htm. (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 26, 2019 Category: Respiratory Medicine Source Type: research
Association of specific metastatic organs with the prognosis and chemotherapeutic response in patients with advanced lung cancer
ConclusionsMuscle and liver metastases were associated with poor outcomes. Muscle and skin metastases were associated with a lower response rate to treatment. For patients with advanced lung cancer, oncologists should select treatment strategies considering the patients’ metastatic statuses as well as other clinical characteristics. (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 19, 2019 Category: Respiratory Medicine Source Type: research
Objective measurement of nocturnal cough in infants with acute bronchiolitis
ConclusionsOur data demonstrated that the number of coughing events due to acute bronchiolitis was similar to that of acute asthma exacerbation, although the acute bronchiolitis did not show a characteristic overnight cough pattern. (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 19, 2019 Category: Respiratory Medicine Source Type: research
Outcomes of prolonged mechanical ventilation in patients who underwent bedside percutaneous dilatation tracheostomy in intermediate care units – A single center study
ConclusionThe prognosis of CCI patients in intermediate care units is generally poor. Identified risk factors for complications and survival should be presented to patients and their surrogates when discussing courses of action and future treatments. (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 18, 2019 Category: Respiratory Medicine Source Type: research
Interstitial pneumonitis associated with dasatinib: two case reports and literature review
Publication date: Available online 13 July 2019Source: Respiratory InvestigationAuthor(s): Yuhei Ito, Motoaki Tanigawa, Keisuke Iwamoto, Akina Nigi, Hidetoshi Itani, Shigeto Kondo, Toshiya Tokui, Eiji Usui, Shigehisa TamakiAbstractDasatinib has increasingly been used to treat chronic myeloid leukemia (CML), although interstitial pneumonitis has been found as a complication in large clinical trials. In the present study, 23 patients received dasatinib for CML between 2012 and 2017 at our institution, of whom 2 developed symptomatic interstitial pneumonitis. Notably, the first patient developed interstitial pneumonitis five ...
Source: Respiratory Investigation - July 14, 2019 Category: Respiratory Medicine Source Type: research
Editorial Board
Publication date: July 2019Source: Respiratory Investigation, Volume 57, Issue 4Author(s): (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 5, 2019 Category: Respiratory Medicine Source Type: research
Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-small cell lung cancer
ConclusionsPre-existing ILA are risk factors for ICI-ILD and GGA in ILA is an independent risk factor for ICI-ILD. Therefore, we should be more aware of the development of ICI-ILD in patients with ILA, especially those with GGA. (Source: Respiratory Investigation)
Source: Respiratory Investigation - June 25, 2019 Category: Respiratory Medicine Source Type: research
Acute or subacute progressive interstitial pneumonia
Publication date: Available online 24 June 2019Source: Respiratory InvestigationAuthor(s): Tomoo Kishaba (Source: Respiratory Investigation)
Source: Respiratory Investigation - June 24, 2019 Category: Respiratory Medicine Source Type: research
Clinical features of interstitial pneumonia associated with systemic lupus erythematosus
ConclusionIn SLE cases, IP primarily occurred in male and elderly patients. In addition to the NSIP pattern, the UIP pattern was evident on HRCT scans of IP-related SLE. The survival of SLE patients was unrelated to IP. (Source: Respiratory Investigation)
Source: Respiratory Investigation - June 22, 2019 Category: Respiratory Medicine Source Type: research
Sex-specific differences in the association between birth weight and lung volume in Japanese young adults
ConclusionsBirth weight is significantly associated with pulmonary function in Japanese young adults. The associations are especially significant in males. (Source: Respiratory Investigation)
Source: Respiratory Investigation - June 15, 2019 Category: Respiratory Medicine Source Type: research
Programmed cell death-ligand 1 expression and efficacy of cisplatin-based chemotherapy in lung cancer: A sub-analysis of data from the two Okayama Lung Cancer Study Group prospective feasibility studies
ConclusionPD-L1 expression was negatively correlated with survival in patients receiving cisplatin-based chemotherapy. (Source: Respiratory Investigation)
Source: Respiratory Investigation - June 9, 2019 Category: Respiratory Medicine Source Type: research
Editorial Board
Publication date: May 2019Source: Respiratory Investigation, Volume 57, Issue 3Author(s): (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 24, 2019 Category: Respiratory Medicine Source Type: research
Patients with unresectable stage III non-small cell lung cancer eligible to receive consolidation therapy with durvalumab in clinical practice based on PACIFIC study criteria
ConclusionIn clinical practice, approximately 70% of patients with unresectable stage III NSCLC would be eligible to receive consolidation therapy with durvalumab. (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 17, 2019 Category: Respiratory Medicine Source Type: research
