The updated classification of PVOD/PCH: A slight but meaningful change
Publication date: Available online 15 May 2019Source: Respiratory InvestigationAuthor(s): Seiichiro Sakao (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 16, 2019 Category: Respiratory Medicine Source Type: research
Development of a CT image case database and content-based image retrieval system for non-cancerous respiratory diseases: Method and preliminary assessment
ConclusionsAlthough this was a preliminary small-scale assessment, the results suggest that this system may contribute to an improved interpretation of CT findings and differential diagnosis of non-cancerous respiratory diseases, which are difficult to diagnose for inexperienced physicians. (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 16, 2019 Category: Respiratory Medicine Source Type: research
Diagnostic difficulty in idiopathic pulmonary fibrosis
Publication date: Available online 14 May 2019Source: Respiratory InvestigationAuthor(s): Yasuhiro Kondoh (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 14, 2019 Category: Respiratory Medicine Source Type: research
Four-meter gait speed predicts daily physical activity in patients with chronic respiratory diseases
ConclusionsThe 4MGS test is a simple screening test and a useful predictor of worsening daily activity in patients with chronic respiratory diseases. (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 13, 2019 Category: Respiratory Medicine Source Type: research
Handgrip strength measurement in patients with chronic obstructive pulmonary disease: Possible predictor of exercise capacity
ConclusionsWe found that HGS was significantly correlated with the 6MWD compared with spirometric measurements or respiratory muscle strength parameters in Japanese patients with COPD, suggesting that HGS could be a simple and noninvasive predictor of the 6MWD in patients with COPD. (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 12, 2019 Category: Respiratory Medicine Source Type: research
Cause of pleuroparenchymal fibroelastosis following allogeneic hematopoietic stem cell transplantation
Publication date: Available online 9 May 2019Source: Respiratory InvestigationAuthor(s): Hisao Higo, Nobuaki Miyahara, Akihiko Taniguchi, Yoshinobu Maeda, Katsuyuki KiuraAbstractLate-onset noninfectious pulmonary complications (LONIPCs) are life-threatening complications after hematopoietic stem cell transplantation (HSCT). Pleuroparenchymal fibroelastosis (PPFE) is a LONIPC, but its etiology remains elusive. Chronic graft-versus-host disease (cGVHD) and alkylating agents used for conditioning have been considered possible causes of PPFE. Therefore, to investigate the primary cause of PPFE in allogeneic HSCT, we compared t...
Source: Respiratory Investigation - May 10, 2019 Category: Respiratory Medicine Source Type: research
Application of a commercial serodiagnostic kit that measures the serum anti-glycopeptidolipid core IgA antibody in Mycobacterium avium complex pulmonary disease
Publication date: Available online 10 May 2019Source: Respiratory InvestigationAuthor(s): Seigo KitadaAbstractThe diagnosis of Mycobacterium avium complex (MAC) pulmonary disease is occasionally cumbersome and time-consuming because the MAC species is ubiquitous, and therefore its detection is not necessarily indicative of a definitive diagnosis. A serodiagnostic method specific for MAC pulmonary disease that measures the serum anti-glycopeptidolipid core antigen IgA has been developed and is commercially available. Meta-analysis revealed that the test showed a good diagnostic accuracy. The estimated sensitivity and specif...
Source: Respiratory Investigation - May 10, 2019 Category: Respiratory Medicine Source Type: research
Chronic obstructive pulmonary disease and the early stage of cor pulmonale: A perspective in treatment with pulmonary arterial hypertension-approved drugs
Publication date: Available online 10 May 2019Source: Respiratory InvestigationAuthor(s): Seiichiro SakaoAbstractCor pulmonale is right ventricular hypertrophy and/or dilation caused by pulmonary hypertension (PH) due to diseases affecting the lung function and structure. Recently, the definition of PH was revised from a mean pulmonary arterial pressure (mPAP)>25 mmHg to an mPAP>20 mmHg based on the Nice statement; this might expedite the detection of cor pulmonale. However, the only treatment for cor pulmonale for the past 3 decades has been to maintain the lung function and oxygen saturation.Chronic obstructive pulmona...
Source: Respiratory Investigation - May 10, 2019 Category: Respiratory Medicine Source Type: research
Diagnostic utility of transbronchial lung cryobiopsy: Two cases of anti-aminoacyl-tRNA synthetase syndrome with respiratory failure
Publication date: Available online 1 May 2019Source: Respiratory InvestigationAuthor(s): Hanako Yoshimura, Nobuyasu Awano, Minoru Inomata, Naoyuki Kuse, Mari Tone, Tatsunori Jo, Tamiko Takemura, Toshio Kumasaka, Takehiro IzumoAbstractTransbronchial lung cryobiopsy (TBLC) is a useful and safe method for the diagnosis of interstitial lung disease (ILD). Herein, we describe the cases of two patients who developed ILD from anti-aminoacyl-tRNA synthetase syndrome with respiratory failure. TBLC was performed instead of surgical lung biopsy. There were no complications, and sufficient specimens were harvested to make the precise ...
Source: Respiratory Investigation - May 2, 2019 Category: Respiratory Medicine Source Type: research
Pulmonary interstitial emphysema is a risk factor for poor prognosis and a cause of air leaks
ConclusionsWe found that pulmonary interstitial emphysema is an independent factor for poor prognosis, which also shows a trend to cause air leaks, including pneumothorax and mediastinal emphysema. (Source: Respiratory Investigation)
Source: Respiratory Investigation - April 29, 2019 Category: Respiratory Medicine Source Type: research
Serum amyloid A in patients with idiopathic pulmonary fibrosis
ConclusionsSAA is a promising marker of disease severity in patients with IPF. Our preliminary data suggest a potential pathogenetic role of alteration in lipid metabolism in this rare disease. (Source: Respiratory Investigation)
Source: Respiratory Investigation - April 26, 2019 Category: Respiratory Medicine Source Type: research
HIRA-TAN detects pathogens of pneumonia with a progressive course despite antibiotic treatment
ConclusionsThe result warrants a larger clinical trial to confirm the clinical efficacy of the HIRA-TAN in patients with progressive pneumonia despite previous antibiotic treatment. (Source: Respiratory Investigation)
Source: Respiratory Investigation - April 26, 2019 Category: Respiratory Medicine Source Type: research
Possible pathogenic roles of nitric oxide in asthma
Publication date: Available online 22 April 2019Source: Respiratory InvestigationAuthor(s): Kazuhiro Yatera, Hiroshi MukaeAbstractNitric oxide (NO) has broad physiologic functions, including vasodilation, bronchodilatation, neurotransmission, inflammation, and host defense. Fraction of exhaled NO (FeNO) is used as a biomarker of eosinophilic airway inflammation for asthma control. However, the role of NO in the pathogenesis and progression of asthma is not well understood. Additionally, the absence of bronchial eosinophilic inflammation, mucus hypersecretion, and increased Th2 cytokine levels in mice lacking NO synthase is...
Source: Respiratory Investigation - April 23, 2019 Category: Respiratory Medicine Source Type: research
Characteristics and association with survival of respiratory-related hospitalization in Japanese idiopathic pulmonary fibrosis patients
ConclusionsPneumonia is the most frequent cause of respiratory-related hospitalization in Japanese IPF patients. Furthermore, respiratory-related hospitalization is significantly associated with subsequent poor survival. (Source: Respiratory Investigation)
Source: Respiratory Investigation - April 17, 2019 Category: Respiratory Medicine Source Type: research
Evaluation of changes in the serum levels of Krebs von den Lungen-6 and surfactant protein-D over time as important biomarkers in idiopathic fibrotic nonspecific interstitial pneumonia
ConclusionsChanges in serum KL-6 and SP-D levels over time may provide useful predictive information on disease behavior during treatment in patients with idiopathic f-NSIP and especially in those with non-IPAF f-NSIP. (Source: Respiratory Investigation)
Source: Respiratory Investigation - April 17, 2019 Category: Respiratory Medicine Source Type: research
