Recent Patents on Anti-Infective Drug Discovery 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Methicillin-Resistant Staphylococcus aureus: Treatment with Cultures of Non Drug-Resistant Staphylococcus epidermidis.
Authors: Werner FM, Covenas R
Abstract
The colonization and infection with methicillin-resistant Staphylococcus aureus is a major health problem in hospitals and long-term care facilities. Although bacteriaemias with MRSA (methicillin-resistant Staphylococcus aureus) can be treated with vancomycin and other reserve antibiotics, 20% of patients cannot be successfully cured. Inpatients colonized with MRSA are isolated in hospitals according to the guidelines of the Robert-Koch-Institute, although in long-term care facilities these patients are not urgently isolated. Active decolonization measures are taken t...
Source: Recent Patents on Anti-Infective Drug Discovery - October 27, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Site Targeted Press Coated Delivery of Methylprednisolone using Eudragit RS 100 and Chitosan for Treatment of Colitis.
CONCLUSION: In-vivo x-ray placebo study for formulation B2 had shown that the tablet reached to the ascending colon after 5 hours. This indicated a potential site targeted delivery of optimized batch B2.
PMID: 26377799 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - September 18, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Chloroquine: An Old Drug With New Perspective Against Giardiasis.
Authors: Escobedo AA, Almirall P, Cimerman S, Lalle M, Pacheco F, Acanda CZ, Sánchez N
Abstract
The occurrence of treatment failures to first-line treatment for giardiasis, one of the most widespread although neglected parasitic disease, has long been recognised. Nowadays, it starts to represent a great challenge to clinicians, especially in endemic countries. This requires the introduction of new drug interventions, but the development of novel drugs is a time and money consuming effort with most of the compounds never reaching the market. Consequently, alternative strategies are needed, especially for t...
Source: Recent Patents on Anti-Infective Drug Discovery - September 15, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Antibiotic Susceptibility Patterns of Extended Spectrum beta-lactamase and non Extended Spectrum beta-lactamase Pseudomonas aeruginosa Clinical Isolates.
CONCLUSION: based on our knowledge obtained from results, both ESBL and non-ESBL P. aeruginosa were resistant to extended antibiotics and this is a major health care problem. On the other hand, MDR strains more identified in ESBL producer P .a eruginosa. Also, carabapenem resistance observed in non-ESBL producer strains. Hence, it is recommended that the MDR strains should be following up. the prescription of ceftazidim, ciprofloxacin, Ticarcillin and aztreonam should be limited.
PMID: 26324233 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - September 4, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Methicillin-resistant Staphylococcus aureus: treatment with cultures of not drug-resistant Staphylocuccus epidermidis.
Authors: Werner FM, Coveñas R
Abstract
The colonization and infection with methicillin-resistant Staphylococcus aureus is a major health problem in hospitals and long-term care facilities. Although bacteriaemias with MRSA (methicillin-resistant Staphylococcus aureus) can be treated with vancomycin and other reserve antibiotics, 20% of patients cannot be successfully cured. Inpatients colonized with MRSA are isolated in hospitals according to the guidelines of the Robert-Koch-Institute, althouth in long-term care facilities these patients are not urgently isolated. Active decolonization measures are taken ...
Source: Recent Patents on Anti-Infective Drug Discovery - August 29, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
A Novel Advanced Laboratory Diagnosis to Guide Tuberculosis Drug Therapy.
Authors: Amaral L, van Soolingen D
Abstract
Tuberculosis presenting severe resistance, defined as extensively drug resistant tuberculosis (XDR TB) continues to increase world-wide to the point that resistance to all available drugs, defined as totally drug resistant tuberculosis (TDR TB) is now significantly present in India, Iran, and other countries (ex. China) and regions (ex. Central Asia) where multi-drug resistance is commonplace. Although the need for new- and more effective drugs is urgent, control of tuberculosis lies primarily in early case finding, prevention of transmission and successful thera...
Source: Recent Patents on Anti-Infective Drug Discovery - August 4, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Optimal antibiotic dosage for chronic kidney disease patient: a pharmacological manual for oral clinicians.
Authors: Chidambaram R
Abstract
Chronic kidney disease, (CKD) a gradual and inevitable deterioration in renal function, is the disease with the most associations in dentistry. Dosage adjustment is one among the vital elements to be familiar with, during their oral care. CKD patients take extended duration to filter out medications, therefore, dosage must always be tailored under the supervision of nephrologist. The relished benefits from antibiotic could transform as anti-microbial resistance on its abuse and nephrotoxic when contraindicated drugs are encouraged. It's a comeback for antibiotics as new pate...
Source: Recent Patents on Anti-Infective Drug Discovery - July 31, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Preface.
Authors: Kabelitz D
PMID: 26203470 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - July 25, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
The Human Epidermal Antimicrobial Barrier: Current Knowledge, Clinical Relevance and Therapeutic Implications.
Authors: Gunathilake R
Abstract
Most of the defensive functions of the human skin are localized to the stratum corneum (SC), the outermost layer of the epidermis consisting of several layers of cornified keratinocytes embedded in a lipid matrix. Included in the armamentarium of the epidermal barrier against microbial invasion are surface pH, SC lipids, specialized antimicrobial peptides such as defensins and cathelicidins, enzymes and enzyme inhibitors, chemokines, and epidermal Toll-like receptors. Multiple epidermal defensive mechanisms are co-localized, co-regulated, and intertwined. The purpose of this...
Source: Recent Patents on Anti-Infective Drug Discovery - June 25, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Antiseptic Resistance in Methicillin Sensitive and Methicillin Resistant Staphylococcus aureus Isolates from Some Major Hospitals, Iran.
CONCLUSION: We found SCCmec types III, Vc was related to high MIC of biocide in MRSA isolates.
PMID: 26100979 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - June 25, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Current status of chemically synthesized inhibitors of ebola virus.
Authors: Cardile AP, Mayers DL, Bavari S
Abstract
The current Ebola virus outbreak is unprecedented in its scope and international impact. Given that there are currently no approved antivirals to treat Ebola virus, there is urgency to conduct more rapid development and evaluation of Ebola antivirals. Recently, the World Health Organization identified a number of antivirals as high priority to include AVI-6002 (AVI-7537 and AVI-7539), BCX4430, brincidofovir, favipiravir, and TKM-100802. This review describes these chemically synthesized inhibitors of Ebola virus, relevant patent development and gives an upd...
Source: Recent Patents on Anti-Infective Drug Discovery - June 4, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Opinion paper: why should governments invest in antibiotic drug discovery against multi-drug-resistant bacteria?
Authors: Meletis G
PMID: 25851116 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - June 4, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Crofelemer: In HIV Associated Diarrhea and Secretory Diarrhea - A Patent Perspective.
CONCLUSION: Crofelemer is a first-in-class agent that possesses a unique mechanism of action through dual inhibition of both the intestinal chloride channels in secretory diarrhea.
PMID: 25851117 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - June 4, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Invited Editorial: MERS-CoV An Emerging Viral Zoonotic Disease: Three Years After and Counting.
Authors: Memish ZA
PMID: 25851253 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - June 4, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Invited editorial: chikungunya, the 2014, emerging infectious diseases in the americas.
Authors: Alpuche-Aranda CM, Lopez-Gatell H
PMID: 25851254 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - June 4, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
