Recent Patents on Anti-Infective Drug Discovery 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Antibiotic Effects of Loperamide:Homology of human targets of Loperamide with targets in Acanthamoeba spp.
CONCLUSION: Though, Acanthamoeba does not express a homolog of the human mu-opioid receptor, but does shows evidence of the homologs for other known human targets of Loperamide that are involved in Ca+2 uptake and Ca+2 signal transduction pathways. This suggests optimization of similar drug interactions with these targets may be useful in developing new approaches to control the growth of this parasite and possibly the diseases caused by it.
PMID: 28506204 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - May 20, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Nanoemulsion for the Effective Treatment and Management of Anti-tubercular Drug Therapy.
CONCLUSION: The nanoemulsion loaded with antitubercular drugs can easily cross the biological barriers to reach the systemic circulation and consequently in the target for reducing the load of Mycobacterium tuberculosis. Besides, the lipidic nature of such systems facilitate targeting of the drugs to the lymph nodes, thus improves drug bioavailability and reduction of the dosing frequency. In lieu of this, the present article compiles the basics of nanoemulsions in brief along with an updated account on their applications in delivering antitubercular drugs for enhanced immunization. Moreover, overview of patent literature ...
Source: Recent Patents on Anti-Infective Drug Discovery - May 11, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Current approaches and future prospects of nanomedicines in tuberculosis therapy.
Authors: Athar MT, Ullah Z
Abstract
Tuberculosis (TB), which is caused by the Mycobacterium tuberculosis, is a serious threat and one of the major health problems worldwide. In recent years, an estimated of 9.6 million TB cases occurred and 1.5 million death occurred due to TB worldwide. The present review is an attempt to introduce this disease focusing on the pathophysiology of the disease, the current approachesand the related patents for treatment and the future planningfor combating this disease.
PMID: 28443511 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - April 28, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Oral colonization by nosocomial pathogens during hospitalization in invasive care unit and prevention strategies.
CONCLUSION: Finally, we discuss about the prevention strategies against oral colonization of nosocomial pathogens includes classic methods and novel methods such as Photodynamic therapy, NO based therapy, anti-virulence therapy and other new under investigation antimicrobial strategies.
PMID: 28215171 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - February 22, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
3rd Generation of Cephalosporins and Monobactam Resistant among Pathogenic Bacteria Collected from Ilam Hospitals during 2008 to 2015: A Systematic Review and Meta-analysis.
CONCLUSION: Antibiotic resistance had increased (except for aztreonam) during the period from 2008 to 2013.
PMID: 28137227 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - February 2, 2017 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Targets and patented drugs for chemotherapy of Chagas disease in the last 15 years-period.
Authors: Duschak VG
Abstract
The American trypanosomiasis, Chagas disease, is a parasitic infection typically spread by triatomine vectors affecting millions of people all over Latin America. Existing chemotherapy is centered on the nitroaromatic compounds benznidazole and nifurtimox that provide unsatisfactory results and substantial side effects. So, the finding and exploration of novel ways to challenge this neglected disease is a main priority. The biologic and biochemical progress in the scientific knowledge of Trypanosoma cruzi in the period comprising the last 15-years, has increased the identificat...
Source: Recent Patents on Anti-Infective Drug Discovery - October 29, 2016 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Correlation Between qacE and qacE Δ1 Efflux Pump Genes, Antibiotic and Disinfectant Resistant Among Clinical Isolates of E.coli.
CONCLUSION: Our study indicated that there was a strong correlation between presence of qacE and qacΔE genes with resistant to some antibiotics and growing in media which contain high concentration of disinfectant. In conclusion, also other mechanisms play important role in resistant to antimicrobial agents but the role of efflux pumps in resistant to antimicrobial agents should not neglected.
PMID: 27527725 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - August 18, 2016 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Detection of blaKPC and blaGES carbapenemase genes in Klebsiella pneumoniae isolated from hospitalized patients in Kashan, Iran.
In this study we have detected the blaKPC and blaGES carbapenemase genes and integron class 1 in Klebsiella pneumoniae isolated from hospitalized patient in Kashan, Iran. In a cross-sectional study, a total of 181 K. pneumoniae isolates were recovered K. pneumoniae from clinical specimens during November 2013 to October 2014. Antimicrobial susceptibility profiles were determined using disk diffusion method according to CLSI guidelines. Carbapenem-resistant K. pneumoniae isolates were identified. PCR method and sequencing were used for detection of integron class 1 and blaKPC and blaGES carbapenemase genes. Of the 181 K. pn...
Source: Recent Patents on Anti-Infective Drug Discovery - August 18, 2016 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Complement 3 Receptor Expression in Individuals with Type 2 Diabetes.
CONCLUSION: This study utilizes a quantitative PCR (qPCR), demonstrating decreased transcription of C3R mRNA in patients with T2DM as compared to non-diabetics.
PMID: 27291248 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - June 15, 2016 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Lipid-based Vesicular Nanocargoes as Nanotherapeutic Targets for the Effective Management of Rheumatoid Arthritis.
CONCLUSION: The present review, therefore, covers the brief pathophysiology of RA, current medication and their challenges in RA therapy. Besides, an extensive account on recent advancements in novel lipid vesicular nanocarriers in RA therapy has also been addressed with special emphasis on the patent literature too.
PMID: 27193030 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - May 20, 2016 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Hybolites Revisited.
Authors: Norris V, Verrier C, Feuilloley M
Abstract
BACKGROUND: Hyperstructures are large assemblies of molecules and macromolecules that perform functions such as metabolism (including RNA and protein synthesis and degradation), transport, DNA replication, cell division, signalling and chemotaxis.
METHODS: Such hyperstructures might be manipulated by hybrid metabolites or hybolites made by a pairwise, covalently linked combination of the thousands of small molecules involved in metabolism and signalling.
RESULTS: Here, we review recent evidence for hyperstructures in prokaryotes and for in...
Source: Recent Patents on Anti-Infective Drug Discovery - April 9, 2016 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Effect of low dose oral vitamin-D and calcium replacement in HIV patients.
Conclusion After 12 months of follow up, replacement of low dose once daily oral vitamin-D with calcium in treatment experienced HIV patients with vitamin-D deficiency can increase vitamin-D level, reduce PTH level without any change in BMD of hip and spine.
PMID: 26844688 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - February 5, 2016 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
The Antidiabetic Effects of The Bioactive Flavonoid (Kaempferol-3-O-β-D-6{P- Coumaroyl} Glucopyranoside) Isolated From Allium cepa.
Authors: Ikechukwu OJ, Ifeanyi OS
Abstract
Allium cepa has been in use in traditional medicine in treatment of diabetes mellitus. The aqueous and ethanolic extracts have been found effective in lowering blood glucose levels in experimental diabetic rats and guinea pigs. The study was carried out to isolate the active principle responsible for the observed hypoglycaemic effect in experimental animals. Freeze-dried aqueous extract of Allium cepa was separated into various fractions using column chromatography with silica gel as stationary phase. The column was eluted with various ratios of mixtures of hexane...
Source: Recent Patents on Anti-Infective Drug Discovery - November 7, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Effect of Pistacia atlantica fruit and leaf extracts on hydatid cyst protoscolices.
CONCLUSION: Information from the current study have shown that the strong scolicidal effective fresh fruit hydroalcoholic extract of Pistacia atlantica on protoscoleces, which may be used as a scolicidal agent during the surgery techniques.
PMID: 26510900 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - October 30, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
In vitro Antimicrobial Study for Biological Evaluation of Clerodendrum infortunatum Linn.
Conclusion: The findings evidently appear promising antibacterial and antifungal properties of C. infortunatum against antagonistic pathogens. Leaf possess quite potent activity than root and stem specially root extract > leaf extract > stem extract. One of the more significant achievements of this study to follows and covers the most recent and important patents WO2009075290 (2009) which deals on yeast having immunopotentiating effect and food or feed. This study serves as basis for further research to lead compounds to be isolated so that may be as a template for the implications of these results for bioactivity an...
Source: Recent Patents on Anti-Infective Drug Discovery - October 27, 2015 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
