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Prophylactic activity of biogenic selenium nanoparticles against chronic Toxoplasma gondii infection.
CONCLUSION: The results of the present study showed a new patent in the treatment of toxoplasmosis; so that taking the biogenic selenium nanoparticles in concentrations of 2.5-10 mg/kg for 2 weeks was able to prevent severe symptoms of the toxoplasmosis in mice model. This indicated the prophylactic effects of SeNPs with no considerable toxicity against latent toxoplasmosis. However, more studies are required to elucidate the correct anti-Toxoplasma mechanisms of SeNPs. PMID: 32496989 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - June 5, 2020 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Perspective in Topical Infective and Non-infective Skin Diseases Therapy with Emergence of Nanomedicine.
Authors: Rahman M, Beg S PMID: 31722657 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - November 15, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

The Chemical composition and anti-mycobacterial activities of Trachyspermum copticum and Pelargonium graveolens essential oils.
Authors: Kardan-Yamchi J, Mahboubi M, Kazemian H, Hamzelou G, Feizabadi MM Abstract BACKGROUND: Microbial resistance to antibiotics and their adverse effects related to these antibiotics are the matter of global public health in 21th century. Emergence of drug resistant strains has interested the scientists to find the new antimicrobial agents among the medicinal plant's essential oil. METHODS: Anti-mycobacterial effects of Trachyspermum copticum and Pelargonium graveolens essential oils were assessed against multi-drug resistant clinical strains of Mycobacterium tuberculosis, Mycobacterium kansasi...
Source: Recent Patents on Anti-Infective Drug Discovery - October 29, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Investigating The Retention Potential Of Chitosan Nanoparticulate Gel: Design, Development, In-Vitro & Ex-Vivo Characterization.
Investigating The Retention Potential Of Chitosan Nanoparticulate Gel: Design, Development, In-Vitro & Ex-Vivo Characterization. Recent Pat Antiinfect Drug Discov. 2019 Oct 14;: Authors: Kaul S, Jain N, Pandey J, Nagaich U Abstract INTRODUCTION: The main purpose of the research was to develop, optimize and characterize tobramycin sulphate loaded chitosan nanoparticles based gel in order to ameliorate its therapeutic efficacy, precorneal residence time, stability, targeting and to provide controlled release of drug. METHODS: Box-Behnken design was used to optimize formu...
Source: Recent Patents on Anti-Infective Drug Discovery - October 17, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Conventional formulations, Challenges and Nanomedicines in Infective and Non-Infective Skin Diseases Therapy.
Authors: Rahman M, Beg S, Akhter S Abstract Oral based formulations for treatment of topical infectious and non-infectious disorders causes numerous adverse reactions including of hepatic toxicity, higher metabolism, poor absorption and serious skin events such as drug - drug interactions resulted from metabolism through the cytochrome P450 system [1-3]. Other prefer routes is topical route, in which drug molecules deliver to the SC or epidermis and retained there for an optimum time to exert it therapeutic effect [3, 4-5]. The skin is an ideal site for drug delivery in treatment of topical infective and n...
Source: Recent Patents on Anti-Infective Drug Discovery - August 12, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Nano-emulgel: Emerging as smarter topical lipidic emulsion based nanocarrier for skin Healthcare applications.
CONCLUSION: Nanoemulgel preparations of many recently approved drugs are being used successfully in different areas of health care and re-defining the significance of topical route of delivery as compared to other routes. However, along with various improvements in current state of delivery system, it also needs a serious concern related to safety and toxicological studies of the materials used for such formulation. PMID: 31333141 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - July 24, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Identification of quinolone and colistin resistance genes in Escherichia coli strains isolated from mucosal samples of patients with colorectal cancer and healthy subjects.
CONCLUSION: These findings indicate increased resistance of E. coli to ciprofloxacin in comparison with prior studies. Further research in this field will increase our knowledge and more effective exposure to the antibiotic resistance of the pathogenic microorganisms. PMID: 31198116 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - June 16, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Lyme Neuroborreliosis - The Mystifying Pitfall: "Neuropathology and Current Therapeutics".
Authors: Chavda V, Patel S Abstract Lyme's Disease (LD) is a severe rapidly growing broad spectrum chronic infection caused by the bacterium 'Borrelia (B.) burgdoferi', which can be easily transmitted through the bite of certain species of ticks. The prevalence of LD is swiftly mounting in present scenario in many countries from species to species. Although Lyme's infection is now detectable via serologic examination of early and late Lyme neuroborreliosis (LNB), the management of persistent symptoms is still fraught with quora of doubt and debate. LD is a multisystem spirochete which results after the dis...
Source: Recent Patents on Anti-Infective Drug Discovery - March 29, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Promising role of Wolbachia as anti-parasitic drug target and eco-friendly biocontrol agent.
CONCLUSION: Wolbachia has opened a new window to design costly, potent and eco-friendly for effective treatment and elimination of vector-borne parasitic diseases. PMID: 30747079 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - February 14, 2019 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Nanomedicine Advances in Topical Infective and Non-Infective Skin Diseases Therapy.
Authors: Rahman M, Akhter S, Beg S Abstract PMID: 30556494 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - December 19, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Patent Selections.
Authors: Abstract PMID: 30556495 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - December 19, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Biological efficacy of carvacrol analogues.
CONCLUSION: Based on several reports on cavarcrol analogues, more research on the development of carvacrol analogues will result in potent compounds that can overcome drug resistance which is currently a challenge in the treatment of diseases such as bacterial infections, cancer, fungal infections etc. However more biological evaluation is required in order to fully understand the mode of action of these analogues on selected pathogens. PMID: 30516115 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - December 7, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Topical nano-emulgel for skin disorders: Formulation approach and characterization.
CONCLUSIONS: From the above studies, it concluded that aqueous-based gel vehicle of the developed formulation system exploited for topical delivery has moisturising properties which can improve local tolerability also. PMID: 30488798 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - December 1, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Polymyxin resistance mechanisms: from intrinsic resistance to mcr genes.
Authors: Meletis G, Skoura L Abstract The global spread of carbapenemase-encoding genes among Gram-negative nosocomial pathogens, has led to the revival of polymyxins. Colistin and polymyxin B, despite their serious adverse effects, have become last resort treatment options for multi- or even extensively-drug-resistant bacterial infections due to Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. Their use however has been followed by an increase in polymyxin resistance rates and the spread of transferable resistance genes limiting further the treatment options and contributing to t...
Source: Recent Patents on Anti-Infective Drug Discovery - November 27, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research

Preface.
Authors: Kabelitz D Abstract PMID: 30424718 [PubMed - in process] (Source: Recent Patents on Anti-Infective Drug Discovery)
Source: Recent Patents on Anti-Infective Drug Discovery - November 16, 2018 Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research