A Novel Advanced Laboratory Diagnosis to Guide Tuberculosis Drug Therapy.

A Novel Advanced Laboratory Diagnosis to Guide Tuberculosis Drug Therapy. Recent Pat Antiinfect Drug Discov. 2015 Aug 3; Authors: Amaral L, van Soolingen D Abstract Tuberculosis presenting severe resistance, defined as extensively drug resistant tuberculosis (XDR TB) continues to increase world-wide to the point that resistance to all available drugs, defined as totally drug resistant tuberculosis (TDR TB) is now significantly present in India, Iran, and other countries (ex. China) and regions (ex. Central Asia) where multi-drug resistance is commonplace. Although the need for new- and more effective drugs is urgent, control of tuberculosis lies primarily in early case finding, prevention of transmission and successful therapy with available drugs. Essential to effective diagnosis and treatment is the appropriate use of a number of laboratory procedures for identification of the infecting bacteria and the selection of effective drugs. Because the outcome of each tuberculosis infection and similar infections by non-tuberculous mycobacteria (NTM) is determined by the nature of the infecting organism, but also depends on the immune response of the patient affected, it is essential that all aspects that contribute to the interaction between bacteria and patient are studied for each specific patient/infecting agent combination. This herein Current Opinion presents a proposed procedure which includes the genetic identification of the isola...
Source: Recent Patents on Anti-Infective Drug Discovery - Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research