Prognostic Significance of Macroscopic Appearance in Clear Cell Renal Cell Carcinoma and Its Metastasis ‐Predicting Model
This study aimed to define the prognostic significance of macroscopic appearance and to propose a prognostic model for post‐operative metastasis in ccRCC. A total of 1,025 patients with ccRCC were analyzed for the development dataset. A separate cohort of 399 such patients was used as an external validation dataset. Macroscopic appearances were initially divided into four groups, but were later divided into two groups: a simple nodular group (700 cases, 68.3%) and an irregular outline group (325 cases, 32.7%). During the 66.1‐month mean follow‐up period, 98 patients (9.6%) developed metastasis. Univariate analysis re...
Source: Pathology International - October 1, 2017 Category: Pathology Authors: Se Un Jeong, Ja ‐Min Park, Su‐Jin Shin, JungBok Lee, Cheryn Song, Heounjeong Go, Nam Hoon Cho, Jae Y. Ro, Yong Mee Cho Tags: Original Article Source Type: research
Pulmonary Langerhans cell histiocytosis “de novo” after lung transplantation
A pulmonary Langerhans cell histiocytosis is presented in a 40 year‐old woman two years after bilateral lung transplantation for emphysema without any signs of Langerhans cells proliferation in the explanted lungs. A microsatellite molecular analysis showed the proliferating cells were generated in a recipient cellular clone. The patient did not quit smoking after transplantation. No signs of disease were detected in the implanted lungs before surgery. Strict control of immunosupressive drug levels stabilized the disease. A “de novo” monoclonal origin of stem cells, probably from the bone marrow is suggested. The rea...
Source: Pathology International - October 1, 2017 Category: Pathology Authors: Javier G ómez‐Román, María Teresa Zarrabeitia, Ana Santurtún, José Antonio Parra, Ainara Azueta Etxebarría, Jose M Cifrian, Javier Freire Salinas Tags: Case Report Source Type: research
Telomerase reverse transcriptase (TERT) promoter mutations are rare in urachal cancer
High rates of telomerase reverse transcriptase (TERT) promoter mutations have recently been described in urothelial carcinoma (UC). Unlike UC in the bladder, adenocarcinomas account for the majority of urachal cancer (UrC) cases. As data in UrC is unclear, we analyzed TERT promoter mutations in a large cohort of UrC for its differential diagnostic, clinicopathological and prognostic significance. UrC cases from six academic centers were analyzed for c.‐146C>T (C250T) and c.‐124C>T (C228T) TERT promoter mutations by PCR and Sanger sequencing. Clinicopathological and survival data were collected. The cohort consist...
Source: Pathology International - October 1, 2017 Category: Pathology Authors: Sebastian Thiem, Thomas Herold, Ulrich Krafft, Felix Bremmer, Yuri Tolkach, Attila M. Sz ász, Joerg Kriegsmann, Nadine T. Gaisa, Christian Niedworok, Tibor Szarvas, Henning Reis Tags: Original Article Source Type: research
Fenton reaction ‐induced renal carcinogenesis in Mutyh‐deficient mice exhibits less chromosomal aberrations than the rat model
Oxidative stress including iron excess has been associated with carcinogenesis. The level of 8‐oxoguanine, a major oxidatively modified base in DNA, is maintained very low by three distinct enzymes, encoded by OGG1, MUTYH and MTH1. Germline biallelic inactivation of MUTYH represents a familial cancer syndrome called MUTYH‐associated polyposis. Here, we used Mutyh‐deficient mice to evaluate renal carcinogenesis induced by ferric nitrilotriacetate (Fe‐NTA). Although the C57BL/6 background is cancer‐resistant, a repeated intraperitoneal administration of Fe‐NTA induced a high incidence of renal cell carcinoma (RCC...
Source: Pathology International - October 1, 2017 Category: Pathology Authors: Guang Hua Li, Shinya Akatsuka, Shan Hwu Chew, Li Jiang, Takahiro Nishiyama, Akihiko Sakamoto, Takashi Takahashi, Mitsuru Futakuchi, Hiromu Suzuki, Kunihiko Sakumi, Yusaku Nakabeppu, Shinya Toyokuni Tags: Original Article Source Type: research
A case of anaplastic lymphoma kinase ‐positive renal cell carcinoma coincident with Hodgkin lymphoma
We report a case of ALK‐positive renal cell carcinoma coincident with Hodgkin lymphoma. The patient was a 19 year‐old‐girl without sickle cell trait. The right renal tumor was discovered concomitantly with Hodgkin lymphoma (HL). After chemotherapy for HL, right nephrectomy was performed. Microscopically, the tumor showed a solid and focally pseudo‐papillary growth pattern studded with tubular structures. Most tumor cells were small bland eosinophilic cells, but rhabdoid cells, vacuolated cells, pleomorphic multinucleated giant cells were also admixed. The variety of growth patterns and cell features led us to specu...
Source: Pathology International - October 1, 2017 Category: Pathology Authors: Yuzo Oyama, Haruto Nishida, Takahiro Kusaba, Hiroko Kadowaki, Motoki Arakane, Tsutomu Daa, Dai Watanabe, Yasuyuki Akita, Fuminori Sato, Hiromitsu Mimata, Shigeo Yokoyama Tags: Case Report Source Type: research
Mesonephric remnant with seminal vesicle ‐like appearance in the cervix
(Source: Pathology International)
Source: Pathology International - October 1, 2017 Category: Pathology Authors: K Koopman, B de Heus, HH de Haan Tags: Letter to the Editor Source Type: research
Whole ‐slide imaging at primary pathological diagnosis: Validation of whole‐slide imaging‐based primary pathological diagnosis at twelve Japanese academic institutes
Several reports have demonstrated the use of whole‐slide imaging (WSI) for primary pathological diagnosis, but no such studies have been published from Asia. We retrospectively collected 1070 WSI specimens from 900 biopsies and small surgeries conducted in nine hospitals. Nine pathologists, who participated in this study, trained for the College of American Pathologists guidelines, reviewed the specimens and made diagnoses based on digitized, 20× or 40× optically magnified images with a WSI scanner. After a washout interval of over 2 weeks, the same observers reviewed conventional glass slides and diagnosed them by lig...
Source: Pathology International - October 1, 2017 Category: Pathology Authors: Kazuhiro Tabata, Ichiro Mori, Takeshi Sasaki, Tomoo Itoh, Taizo Shiraishi, Naoki Yoshimi, Ichiro Maeda, Oi Harada, Kiyomi Taniyama, Daiki Taniyama, Mika Watanabe, Yoshiki Mikami, Shuntaro Sato, Yukio Kashima, Shota Fujimura, Junya Fukuoka Tags: Original Article Source Type: research
A case of mucin ‐producing urothelial‐type adenocarcinoma of the prostate showing immunoreactivity for NKX3.1, a specific marker of prostatic tissue
(Source: Pathology International)
Source: Pathology International - September 3, 2017 Category: Pathology Authors: Takashi Kawasaki, Toshihiro Saito, Katsunori Uchida, Keiji Mio, Hiroaki Nishida, Keiichi Homma Tags: Letter to the Editor Source Type: research
Improved clonality detection in B ‐cell lymphoma using a semi‐nested modification of the BIOMED‐2 PCR assay for IGH rearrangement: A paraffin‐embedded tissue study
In conclusion, tumor clonality may be detected in nearly 90% of B‐cell lymphoma cases with semi‐nested BIOMED‐2. This ancillary assay may be useful when the standard BIOMED‐2 fails to detect clonality in histopathologically suspected B‐cell lymphomas. (Source: Pathology International)
Source: Pathology International - September 3, 2017 Category: Pathology Authors: Yuma Sakamoto, Ayako Masaki, Satsuki Aoyama, Shusen Han, Kosuke Saida, Kana Fujii, Hisashi Takino, Takayuki Murase, Shinsuke Iida, Hiroshi Inagaki Tags: Original Article Source Type: research
Succinate dehydrogenase B ‐deficient renal cell carcinoma: A case report with novel germline mutation
Succinate dehydrogenase‐deficient renal cell carcinoma (SDH‐deficient RCC) is a newly introduced histological type of RCC, which is caused by loss of subunit genes of SDH. It is known to frequently demonstrate familial occurrence and be frequently associated with gastrointestinal stromal tumors and paraganglioma. To date, only 53 cases have been reported. Here, we present an additional case of SDH‐deficient RCC occurring in a 40‐year‐old female. The tumor was histologically biphasic, consisting of tubular and solid architectures. The tumor cells possessed oval nuclei with small nucleoli, and an eosinophilic granu...
Source: Pathology International - September 1, 2017 Category: Pathology Authors: Hiromichi Iwashita, Koji Okudela, Mai Matsumura, Shoji Yamanaka, Tomoe Sawazumi, Makiko Enaka, Naoko Udaka, Akio Miyake, Takashi Hibiya, Noriko Miyake, Naomichi Matsumoto, Kazuhide Makiyama, Masahiro Yao, Yoji Nagashima, Kenichi Ohashi Tags: Case Report Source Type: research
Sporadic minute medullary thyroid carcinoma with a double RET mutation: A case report
This study reports the smallest case of sporadic MTC with a double RET somatic mutation, substantiating that RET mutations can occur during a very early stage of carcinogenesis. The combined presence of C630R and C634W represent a novel somatic mutation in sporadic MTC. The present case indicates that the sporadic MTC originated from the surrounding C‐cells of the SCNs without C‐cell hyperplasia and that the SCN main cells may not be able to develop into an MTC. (Source: Pathology International)
Source: Pathology International - September 1, 2017 Category: Pathology Authors: Hiroyuki Yamamoto, Jun Ishii, Tomohiro Chiba, Yoko Nakazato, Kouichi Hirano, Hiroshi Kamma Tags: Case Report Source Type: research
A Case of the nephrotic syndrome in bone marrow transplantation recipient, histologically showing overlapped glomerular lesions of thrombotic microangiopathy and membranous nephropathy
Nephrotic syndrome (NS) rarely occurs in post‐hematopoietic stem cell transplantation (HSCT) recipients but represents the renal manifestation of graft‐versus‐host disease (GVHD). Membranous nephropathy (MN) accounts for almost two thirds of post‐HSCT NS and is caused by immune complex deposition. Renal thrombotic microangiopathy (TMA) without fulfillment of clinical criteria for TMA has been underreported because of reduced opportunity for histological examination. However, renal TMA has recently been reported in association with GVHD and humoral immunological reactions. Although both MN and TMA after HSCT are ass...
Source: Pathology International - September 1, 2017 Category: Pathology Authors: Naoko Masuzawa, Ayako Nishimura, Takashi Kitani, Keiichi Tamagaki, Mio Sugitani, Hisao Nagoshi, Junya Kuroda, Eiichi Konishi Tags: Case Report Source Type: research
Clear cell sarcoma ‐like tumor of the gastrointestinal tract: A clinicopathological review
(Source: Pathology International)
Source: Pathology International - September 1, 2017 Category: Pathology Authors: Kota Washimi, Masayuki Takagi, Masanori Hisaoka, Kae Kawachi, Masanobu Takeyama, Toru Hiruma, Hiroto Narimatsu, Tomoyuki Yokose Tags: Letter to the Editor Source Type: research
Chronic myocarditis with a long clinical course: Report of an autopsy case of probable autoimmune myocarditis
The patient was a 54‐year‐old woman, who died of chronic cardiac insufficiency after a clinical course of 2 years and 4 months. She had complained of myalgia, muscle weakness, and blepharoptosis before the onset of cardiac symptoms, but there was no evidence of myasthenia gravis or collagen‐vascular diseases. At autopsy, the heart (280 g) showed marked dilatation of the four chambers and thinning of the ventricular walls. Diffuse and intense lymphocytic infiltration and extensive fibrosis were noted, with the latter being accentuated in the subendocardial and subepicardial zones. Small foci of myocardial necrosis w...
Source: Pathology International - September 1, 2017 Category: Pathology Authors: Masayuki Shintaku, Koji Uchiyama, Yohei Kobayashi Tags: Case Report Source Type: research
Skene's gland adenocarcinoma with intestinal differentiation: A case report and literature review
We present a case of Skene's gland adenocarcinoma with intestinal differentiation. The patient was a 69‐year‐old Japanese woman who was operated on for a recurrent tumor of the external ostium of the urethra. Histopathologically, the tumor showed glandular and cribriform patterns with a signet‐ring cell component in a mucus lake. Immunohistochemically, the tumor cells were positive for prostate specific acid phosphatase (PSAP), and AMACR, and negative for Nkx3.1 or prostate specific antigen (PSA). Although in situ lesion could not be discovered, positive immunostainings for Nkx3.1, PSAP, and androgen receptor in the ...
Source: Pathology International - September 1, 2017 Category: Pathology Authors: Mariko Muto, Kentaro Inamura, Naoko Ozawa, Takashi Endo, Hitoshi Masuda, Junji Yonese, Yuichi Ishikawa Tags: Case Report Source Type: research
