Corrigendum
(Source: Pathology International)
Source: Pathology International - March 1, 2017 Category: Pathology Tags: Corrigendum Source Type: research
Laminar crystal deposition in large vessels in a patient with crystalglobulinemia
Crystalglobulinemia is an extremely rare complication of monoclonal gammopathy and is characterized by crystal thrombi within systemic organs. We herein report the first described case of crystalglobulinemia accompanied by laminar crystal deposition in the large vessels. A 44‐year‐old man presented with a history of numbness, pain, and swelling of the left leg in addition to visual impairment. Renal and skin biopsies revealed crystal thrombi within the capillary lumens. The patient was finally diagnosed with crystalglobulinemia associated with multiple myeloma. He was treated with hemodialysis and chemotherapy but died...
Source: Pathology International - March 1, 2017 Category: Pathology Authors: Yukako Shintani ‐Domoto, Aya Shinozaki‐Ushiku, Hidemi Okuma, Mineo Kurokawa, Masashi Fukayama Tags: Case Report Source Type: research
L ‐type amino acid transporter 1 expression in esophageal carcinogenesis according to WHO and Japanese classifications of intraepithelial neoplasia
L‐type amino acid transporter 1 (LAT1) has an essential role in cell proliferation especially in neoplasms. Although immunohistochemical expression of LAT1 has been investigated in invasive esophageal carcinoma, its expression in intraepithelial neoplasia (IEN) has not been reported. Further, classification of esophageal IEN is currently different between the World Health Organization (WHO) and Japanese criteria. Therefore, in this study, immunohistochemical expressions of LAT1 along with Ki‐67 were analyzed in 66 esophageal samples of endoscopic submucosal dissection. Extension of cells positive for either marker with...
Source: Pathology International - March 1, 2017 Category: Pathology Authors: Hirotsugu Hashimoto, Atsushi Kurata, Hiroyuki Kikuchi, Yoshio Masuda, Koji Fujita, Rikiya Okuyama, Shigeru Inoue, Hajime Horiuchi, Masahiko Kuroda Tags: Original Article Source Type: research
Retroperitoneal dedifferentiated liposarcoma with huge cystic degeneration: A case report
We report here a case of dedifferentiated liposarcoma with huge cystic change without preoperative chemo‐ or radiation therapy. The lesion arose in the retroperitoneum juxtaposed to the right kidney of a 67‐year‐old woman. She underwent a surgical removal of the retroperitoneal cyst. The cystic tumor contained 1600 mL of old bloody fluid, and its wall was composed of edematous, inflamed or sclerosing fibrous tissue with fatty tissue containing abundant atypical stromal cells, which were immunohistochemically positive for MDM2 and CDK4, and demonstrated MDM2 gene amplification by fluorescence in situ hybridization. ...
Source: Pathology International - March 1, 2017 Category: Pathology Authors: Kazuyoshi Uchihashi, Atsuji Matsuyama, Eisuke Shiba, Yoshizo Kimura, Toshiro Ogata, Kei Yabuki, Hiroshi Harada, Chisachi Kubo, Yojiro Tsuda, Mao Jotatsu, Masanori Hisaoka Tags: Case Report Source Type: research
Bizarre stromal cells mimicking malignancy in chondro ‐osseous respiratory epithelial adenomatoid hamartoma
(Source: Pathology International)
Source: Pathology International - February 28, 2017 Category: Pathology Authors: Kyriakos Chatzopoulos, Marios Stavrakas, Prodromos Hytiroglou, Stefanos Triaridis Tags: Letter to the Editor Source Type: research
Plaque formation and the intraneuronal accumulation of β‐amyloid in Alzheimer's disease
Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β‐amyloid peptides (Aβ), while NFTs contain hyperphosphorylated tau proteins. Patients with familial AD who have mutations in the amyloid precursor protein (APP) gene have either increased production of Aβ or generate more aggregation‐prone forms of Aβ. The findings of familial AD mutations in the APP gene suggest that Aβ plays a central role in the pathophysiology of AD. Aβ42, composed of 42 amino acid residues, aggregates readily and is considered to fo...
Source: Pathology International - February 28, 2017 Category: Pathology Authors: Reisuke H. Takahashi, Toshitaka Nagao, Gunnar K. Gouras Tags: Review Article Source Type: research
A Case of aggressive solid pseudopapillary neoplasm: Comparison of clinical and pathologic features with non ‐aggressive cases
Solid pseudopapillary neoplasms (SPNs) may have an aggressive clinical course, but clinical predictors of this condition have not been thoroughly evaluated. We performed a retrospective study of 11 cases of SPN managed in our hospital between January 2007 and April 2015. Of these 11 cases, we encountered a single case with an aggressive clinical course. Histological, immunohistochemical, and clinical features were compared to identify predictors of poor prognosis. The 11 patients comprised four women and seven men with a median age of 41 years (range, 26–58 years). Clinical symptoms were nonspecific and the median tumor ...
Source: Pathology International - February 15, 2017 Category: Pathology Authors: Yukihiro Watanabe, Kojun Okamoto, Katsuya Okada, Masayasu Aikawa, Isamu Koyama, Hiroshi Yamaguchi Tags: Case Report Source Type: research
Solid pseudopapillary neoplasm expresses inhibin ‐α and Tcf‐3
(Source: Pathology International)
Source: Pathology International - January 31, 2017 Category: Pathology Authors: Shirai et al., Yoko Shirai, Yasunori Enomoto, Toru Harada, Koji Asai, Shuichi Ashizuka, Masahiro Ikegami, Kei Takahashi, Norikazu Shimizu, Takashi Sekine Tags: Letter to the Editor Source Type: research
A rare case of TFE ‐related pigmented renal tumor with overlapping features between melanotic Xp11 translocation renal cancer and Xp11 renal cell carcinoma with melanotic features
In recent years, an increasing number of TFE3 rearrangement‐associated tumors with melanotic features have been reported as primary neoplasm in different anatomical sites, including the kidney. Melanotic Xp11 translocation renal cancer (MXTRC) and Xp11 renal cell carcinoma with melanotic features (XRCCM) have been proposed to be main categories for pigmented lesions in the microophthalmia‐associated transcription factor (MiTF/TFE3) family of renal tumors that may show variable degrees of melanocytic differentiation. Herein we report a rare case of TFE3‐related pigmented renal tumor showing unusual immunoexpression of...
Source: Pathology International - January 31, 2017 Category: Pathology Authors: Leonardo Cardili, Greg ório Wrublevsky Pereira, Cristiano Ribeiro Viana Tags: Case Report Source Type: research
Composite lymphoma of peripheral T ‐cell lymphoma and Hodgkin lymphoma, mixed cellularity type; pathological and molecular analysis
Composite lymphomas (CLs) are defined as two unrelated lymphomas occurring at the same time within the same tissue. The incidence of these tumors is low. Of all possible combinations between lymphomas, the least frequent are the ones combining peripheral T‐cell lymphoma (PTCL) and Hodgkin lymphoma (HL). We recently identified five cases of CL composed of PTCL and classical HL, mixed cellularity type. We investigated histological and clinical features of these cases. Immunostaining was performed on paraffin sections. PTCL cells were positive for CD8 and TIA‐1 in four of the five cases. Hodgkin and Reed‐Sternberg (HRS)...
Source: Pathology International - January 31, 2017 Category: Pathology Authors: Ayako Ichikawa, Hiroaki Miyoshi, Takuji Yamauchi, Fumiko Arakawa, Riko Kawano, Hiroko Muta, Yasuo Sugita, Koichi Akashi, Koichi Ohshima Tags: Original Article Source Type: research
Primary giant cell tumor of the common bile duct: No mutation H3F3A found
(Source: Pathology International)
Source: Pathology International - January 19, 2017 Category: Pathology Authors: Aur élie Beaufrère, Frédérique Larousserie, Safi Dokmak, Eric Pasmant, Janick Selves, Dominique Cazals‐Hatem Tags: Letter to the Editor Source Type: research
Pathogenesis of developmental anomalies of the central nervous system induced by congenital cytomegalovirus infection
In humans, the herpes virus family member cytomegalovirus (CMV) is the most prevalent mediator of intrauterine infection‐induced congenital defect. Central nervous system (CNS) dysfunction is a distinguishing symptom of CMV infection, and characterized by ventriculoencephalitis and microglial nodular encephalitis. Reports on the initial distribution of CMV particles and its receptors on the blood brain barrier (BBB) are rare. Nevertheless, several factors are suggested to affect CMV etiology. Viral particle size is the primary factor in determining the pattern of CNS infections, followed by the expression of integrin β1...
Source: Pathology International - January 9, 2017 Category: Pathology Authors: Hideya Kawasaki, Isao Kosugi, Shiori Meguro, Toshihide Iwashita Tags: Review Article Source Type: research
Notice to Contributors
(Source: Pathology International)
Source: Pathology International - January 1, 2017 Category: Pathology Tags: Notice to Contributors Source Type: research
Ciliated muconodular papillary tumor of the lung harboring ALK gene rearrangement: Case report and review of the literature
Ciliated muconodular papillary tumor (CMPT) of the lung is an extremely rare peripheral tumor of the lung. The pathogenesis of CMPT is still unknown, and its nature as a benign tumor or reactive process is still open to discussion. Recent studies have identified BRAF, EGFR and AKT1 mutations in CMPT, which would support a true neoplastic process. Here for the first time, we report a case of morphologically typical CMPT harboring ALK gene rearrangement to further provide convincing evidence that CMPT is a neoplastic process rather than a reactive lesion. The patient was a 59‐year‐old woman, characterized by a circumscri...
Source: Pathology International - December 31, 2016 Category: Pathology Authors: Yan Jin, Xuxia Shen, Lei Shen, Yihua Sun, Haiquan Chen, Yuan Li Tags: Case Report Source Type: research
Clinicopathological importance of anterior prostate cancer in Japanese Men
Prostate cancer of transition zone origin or anterior location has been recognized as infrequent, smaller in size and indolent, whereas, our previous report showed that transition zone/anterior cancer was frequently experienced in Japanese men. The current study was conducted to show clinicopathological characteristics of transition zone/anterior cancer. A total of 201 radical prostatectomy specimens were categorized as cancer of anterior or posterior prostate where more than two thirds of the tumor existed in the specific area. Clinicopathological characteristics including Gleason score, pathological stage, lymph node met...
Source: Pathology International - December 31, 2016 Category: Pathology Authors: Shun Sato, Hiroyuki Takahashi, Takahiro Kimura, Shin Egawa, Bungo Furusato, Masahiro Ikegami Tags: Original Article Source Type: research
