Microscopic findings in EUS ‐guided fine needle (SharkCore) biopsies with type 1 and type 2 autoimmune pancreatitis
The International Consensus Diagnostic Criteria (ICDC) for the diagnosis of autoimmune pancreatitis (AIP) include the histological criterion that is based on either pancreatic core needle biopsies (CNBs) or surgical specimens. However, CNBs are difficult to obtain by endoscopic ultrasound (EUS). EUS fine‐needle aspiration (EUS‐FNA) cytology is usually not sufficient for the diagnosis of AIP, but may sometimes contain tissue microfragments. Another approach is EUS‐guided histological fine‐needle biopsy (EUS‐FNB), using needles such as the SharkCore or ProCore needle. Published data regarding EUS‐guided SharkCore...
Source: Pathology International - September 1, 2017 Category: Pathology Authors: S önke Detlefsen, Maiken Thyregod Joergensen, Michael Bau Mortensen Tags: Case Report Source Type: research
H ürthle cell carcinoma in an unattached thyroid lobe: A diagnostic challenge
(Source: Pathology International)
Source: Pathology International - August 31, 2017 Category: Pathology Authors: Sofia Lypiridou, Theodosis Papavramidis, Antonios Michalopoulos, Aikaterini Foka ‐Karagiannopoulou, Triantafyllia Koletsa Tags: Letter to the Editor Source Type: research
Detection of tumor spread through airspaces by airway secretion cytology from resected lung cancer specimens
It currently remains unclear whether tumor spread through airspaces (STAS) actually exist in vivo or are an artifact. The morphologies of STAS and tumor cell clusters in airway secretions collected from the segmental or lobar bronchus of resected lung adenocarcinomas and squamous cell carcinomas were compared among 48 patients. The EGFR status of tumor cell clusters in airway secretions was also compared with that of the main tumor in EGFR mutant adenocarcinomas. Tumor cell clusters were observed in the airway secretion cytology of ten patients (20.8%), and eight patients were adenocarcinoma (20.0% of adenocarcinoma). The ...
Source: Pathology International - August 1, 2017 Category: Pathology Authors: Tetsuya Isaka, Tomoyuki Yokose, Yohei Miyagi, Kota Washimi, Teppei Nishii, Hiroyuki Ito, Haruhiko Nakayama, Kouzo Yamada, Munetaka Masuda Tags: Original Article Source Type: research
A case of rectal neuroendocrine carcinoma in a patient with long ‐standing ulcerative colitis involving alterations of the p16‐Rb pathway
The patient was a 54‐year‐old male who had been suffering from extensive ulcerative colitis (UC) for 17 years. Colonoscopy revealed an elevated lesion in the affected rectum, and its biopsy demonstrated neuroendocrine carcinoma (NEC). The surgical specimen obtained on laparoscopic high anterior resection showed extensive active inflammatory and dysplastic lesions and three grossly visible multifocal malignant lesions: a polypoid fungating tumor of NEC (type 1, 20 mm in diameter, pT3) that had been preoperatively noticed, a polypoid fungating tumor of adenocarcinoma (type 1, 22 mm, pT2) and a protruded sessile polyp...
Source: Pathology International - August 1, 2017 Category: Pathology Authors: Tomoko Norose, Nobuyuki Ohike, Hideyuki Imai, Hideki Shibata, Reika Suzuki, Tomohide Isobe, Kunio Asonuma, Yuichiro Kuroki, Masatsugu Nagahama, Jun ‐ichi Tanaka, Masafumi Takimoto Tags: Case Report Source Type: research
Correlation of lanthanum dosage with lanthanum deposition in the gastroduodenal mucosa of dialysis patients
Lanthanum (La) deposition has been observed in gastrointestinal mucosa of dialysis patients treated with La carbonate to treat hyperphosphatemia in the 6 years since its authorization in Japan. We investigated gastrointestinal biopsies from 112 dialysis patients, and found 15 cases of histiocytic aggregation with crystalloids and one case of duodenitis with histiocyte aggregation without crystalloids in the 30 patients treated with La carbonate. No histiocytic lesions were observed in the 82 patients without La carbonate administration. So far in total 70 cases of La deposition in the alimentary tract have been reported, i...
Source: Pathology International - August 1, 2017 Category: Pathology Authors: Kimiaki Hattori, Tamaki Maeda, Shinya Nishida, Miyuki Imanishi, Masahiro Sakaguchi, Yoshifumi Amari, Takuya Moriya, Yoshinobu Hirose Tags: Original Article Source Type: research
Notice to Contributors
(Source: Pathology International)
Source: Pathology International - July 3, 2017 Category: Pathology Tags: Notice to Contributors Source Type: research
Soft tissue sarcomas: From a morphological to a molecular biological approach
Recently developed molecular genetic techniques have led to the elucidation of tumor‐specific genomic alterations and thereby the reclassification of tumor entities of soft tissue sarcoma. A solitary fibrous tumor‐mimicking tumor with the AHRR‐NCOA2 gene has been isolated as angiofibroma of soft tissue. As for small round cell sarcomas, novel fusion genes such as CIC‐DUX4 and BCOR‐CCNB3 have been identified in these tumor groups. SMARCB1/INI1 deficient tumors with round cell morphology are also expected to be reclassified in three types, based on the combination of their morphology and genotype. The identificatio...
Source: Pathology International - July 1, 2017 Category: Pathology Authors: Yoshinao Oda, Hidetaka Yamamoto, Kenichi Kohashi, Yuichi Yamada, Kunio Iura, Takeaki Ishii, Akira Maekawa, Hirofumi Bekki Tags: Review Article Source Type: research
Diagnostic utility of automated SureFISH (Dako Omnis) in the diagnosis of musculoskeletal translocation ‐related sarcomas
Fluorescence in situ hybridization (FISH) is an essential tool for genetic diagnosis in daily pathological work. Almost full automation of FISH can be achieved with the recently released automated SureFISH platform (Dako Omnis, Agilent Technologies, Santa Clara, CA, USA). Its utility has been reported in HER2 amplification of breast and gastric carcinoma and ALK‐rearranged lung cancer. Here, we examined the utility of automated SureFISH for the identification of rearrangement signals in translocation‐related sarcomas (TRSs), including 11 EWSR1‐rearranged and 10 synovial sarcoma cases, compared with non‐automated co...
Source: Pathology International - July 1, 2017 Category: Pathology Authors: Shintaro Sugita, Tomoyuki Aoyama, Yoshimasa Ito, Hiroko Asanuma, Taro Sugawara, Keiko Segawa, Yumika Ito, Noriaki Kikuchi, Mitsuhiro Tsujiwaki, Hiromi Fujita, Yusuke Ono, Tadashi Hasegawa Tags: Short Communication Source Type: research
Expression of interferon regulatory factor 7 correlates with the expression of Epstein –Barr Virus latent membrane protein 1 and cervical lymph node metastasis in nasopharyngeal cancer
Interferon regulatory factor 7 (IRF7) has oncogenic properties in several malignancies such as Epstein–Barr virus (EBV)‐associated lymphoma. However, there is no evidence whether IRF7 is associated with the oncogenesis of nasopharyngeal cancer (NPC), the pathogenesis of which is closely associated with EBV. Herein, we report that expression of IRF7 was increased in normal nasopharyngeal cells that expressed the EBV principal oncoprotein, latent membrane protein 1 (LMP1). In addition, IRF7 was mainly expressed in the nucleus in both normal nasopharyngeal cells and nasopharyngeal cancer cells that expresses LMP1. On immu...
Source: Pathology International - July 1, 2017 Category: Pathology Authors: Satoru Kondo, Kazuhira Endo, Naohiro Wakisaka, Mitsuharu Aga, Makoto Kano, Noriko Seishima, Tomoko Imoto, Eiji Kobayashi, Makiko Moriyama ‐Kita, Yosuke Nakanishi, Shigeyuki Murono, Joseph S. Pagano, Tomokazu Yoshizaki Tags: Short Communication Source Type: research
Expression patterns of claudins in patients with triple ‐negative breast cancer are associated with nodal metastasis and worse outcome
Claudins (CLDNs) are key cell adhesion molecules, which compose tight junctions (TJs), and the disruption of TJs is associated with cancer development. Here we immunohistochemically studied expression patterns of CLDNs in 222 primary invasive breast cancers including 68 triple‐negative breast cancers (TNBCs), and examined their correlation with epithelial‐to‐mesenchymal transition (EMT)‐related markers, breast cancer stem cell (BCSC) markers, and clinicopathological features including patients’ clinical outcome. Tumor margins were classified as three infiltrating growth patterns (expanding, intermediate and infil...
Source: Pathology International - July 1, 2017 Category: Pathology Authors: Ayaka Katayama, Tadashi Handa, Kei Komatsu, Maria Togo, Jun Horiguchi, Masahiko Nishiyama, Tetsunari Oyama Tags: Original Article Source Type: research
Differences between gastric signet ‐ring cell carcinoma and poorly differentiated adenocarcinoma: A comparison of histopathologic features determined by mucin core protein and trefoil factor family peptide immunohistochemistry
We investigated differences between the pathological features of gastric signet‐ring cell carcinoma (sig) and poorly differentiated adenocarcinoma (por) by examining the expressions of the trefoil factor family peptides (TFFs) and mucin core proteins (MUCs). Ninety‐seven tissues of 97 gastric cancer patients were selected for this study. After gastrectomy, the major histopathologic types were determined to be sig, solid‐type poorly differentiated adenocarcinoma (por1), non‐solid type poorly differentiated adenocarcinoma (por2), and well‐differentiated tubular adenocarcinoma (tub1). We evaluated the prevalence of ...
Source: Pathology International - July 1, 2017 Category: Pathology Authors: Ai Fujimoto, Yukio Ishikawa, Toshiharu Ishii, Akihiro Yamada, Yoshinori Igarashi, Yasukazu Ohmoto, Mitsuru Kaise Tags: Original Article Source Type: research
Epithelial ‐to‐mesenchymal transition and its role in EGFR‐mutant lung adenocarcinoma and idiopathic pulmonary fibrosis
Lung adenocarcinoma cells with activating epidermal growth factor receptor (EGFR) mutations are highly dependent upon EGFR signaling for survival and undergo apoptosis when EGFR signaling is inhibited by tyrosine kinase inhibitor (TKI) treatment. Paradoxically, EGFR‐mutant lung adenocarcinomas have subpopulations of cells that can survive independently of activated EGFR. Such EGFR‐independent EGFR‐mutant cancer cells include cells that have undergone epithelial‐to‐mesenchymal transition (EMT) or transformed to small cell lung cancer, which almost completely lack EGFR dependency. The presence of such cells suggest...
Source: Pathology International - July 1, 2017 Category: Pathology Authors: Yuji Sakuma Tags: Review Article Source Type: research
Dedifferentiated carcinoma with clear cell carcinoma of the endometrium: A case report
We report the first case of endometrial dedifferentiated carcinoma with clear cell carcinoma in a 58‐year‐old woman. The uterine corpus was completely replaced and enlarged by a heterogeneous mass. The endometrial cut surface showed a yellowish papillary growing mass involving endometrium and deeper myometrium. Microscopically, the three components (endometrioid carcinoma, FIGO grade 1, clear cell carcinoma and undifferentiated carcinoma) were noted with differentiated carcinoma components lining the endometrial cavity, while undifferentiated carcinoma components were identified in deeper endometrium and myometrium. Ou...
Source: Pathology International - June 30, 2017 Category: Pathology Authors: Seung Eun Lee, Ha young Park, Seung ‐Hyuk Shim, Wook Youn Kim Tags: Case Report Source Type: research
Cytopathologic findings of cell block materials from the vitreous: Diagnostic distinction between intraocular lymphoma and non ‐lymphomatous diseases
In conclusion, careful cytopathological examination or immunocytochemistry of vitreous material facilitates appropriate diagnosis of intraocular lymphoma. (Source: Pathology International)
Source: Pathology International - June 7, 2017 Category: Pathology Authors: Hiromi Kanno ‐Okada, Emi Takakuwa, Yoshiaki Tagawa, Satoru Kase, Kanako C. Hatanaka, Yutaka Hatanaka, Kenichi Namba, Tomoko Mitsuhashi, Yoshihiro Matsuno Tags: Original Article Source Type: research
Fibrotic focus: An important parameter for accurate prediction of a high level of tumor ‐associated macrophage infiltration in invasive ductal carcinoma of the breast
Our group and others have previously reported that a fibrotic focus is a very useful histological factor for the accurate prediction of the outcome of patients with invasive ductal carcinoma of the breast. We classified 258 cases of invasive ductal carcinoma into those with and those without a fibrotic focus to investigate whether the presence of a fibrotic focus was significantly associated with the degree of tumor‐associated macrophage (CD68, CD163 or CD204‐positive) infiltration or whether the presence of tumor‐associated macrophage infiltration heightened the malignant potential of invasive ductal carcinoma with ...
Source: Pathology International - June 7, 2017 Category: Pathology Authors: Hiroko Shimada, Takahiro Hasebe, Michiko Sugiyama, Satomi Shibasaki, Ikuko Sugitani, Shigeto Ueda, Yoshiya Gotoh, Masanori Yasuda, Eiichi Arai, Akihiko Osaki, Toshiaki Saeki Tags: Original Article Source Type: research
