Carcinoma ex basal cell adenoma of the parotid gland: A report of an extremely rare case
Malignant non‐basaloid tumors that arise from basal cell adenoma (BCA) are extremely rare. The patient was a 72‐year‐old Japanese male, who had noticed swelling of the left parotid region 21 years ago. A superficial lobectomy was performed. About 60% of the tumor was made up of cribriform and trabecular tissue composed of basaloid cells, which exhibited mild atypia and nuclear expression of β‐catenin. This portion of the tumor was considered to be a BCA. In the other part of the tumor, the proliferation of large eosinophilic atypical cells, most of which formed intraductal structures, was observed. These tumor cel...
Source: Pathology International - May 1, 2017 Category: Pathology Authors: Kimihide Kusafuka, Takuya Kawasaki, Takashi Nakajima, Takashi Sugino Tags: Case Report Source Type: research
Human intestinal spirochetosis in Japanese patients aged less than 20 years: Histological analysis of colorectal biopsy and surgical specimens obtained from 479 patients
This study aimed to determine the incidence and clinicopathological manifestations of HIS in Japanese patients aged less than 20 years. We retrospectively reviewed 3605 biopsy and 92 surgical specimens obtained from 479 patients admitted to Shinshu University Hospital between 1997 and 2014. All slides were reviewed independently by two pathologists to confirm the histological presence of spirochetes. Among 387 patients who underwent biopsy, the most common pathologic diagnosis was ulcerative colitis (12.6%, n = 49). Additionally, about half of the biopsy specimens showed non‐specific, mildly inflamed mucosa (50.6%, n...
Source: Pathology International - May 1, 2017 Category: Pathology Authors: Shojiro Ichimata, Akihiko Yoshizawa, Mai Kusakari, Yoshiko Nakayama, Shiho Asaka, Tatsuya Negishi, Eriko Kasuga, Takehisa Matsumoto, Takayuki Honda Tags: Short Communication Source Type: research
Pilomatrical carcinosarcoma of the cheek: Immunohistochemical and molecular analysis of beta ‐catenin
(Source: Pathology International)
Source: Pathology International - May 1, 2017 Category: Pathology Authors: Takayuki Suyama, Shuji Momose, Megumi Yokoyama, Jun Kikuchi, Seiichi Izaki, Eiichi Arai, Junichi Tamaru Tags: Letter to the Editor Source Type: research
Expression of p16Ink4a in mixed squamous cell and glandular papilloma of the lung
Mixed squamous cell and glandular papilloma (mixed papilloma) of the lung is an extremely rare neoplasm, with only 21 cases reported in the English literature. Although the expression of p16Ink4a has been analyzed in only two cases of mixed papilloma, they were negative for p16Ink4a. Therefore, the significance of p16Ink4a overexpression in mixed papilloma remains unclear. This is the first case of mixed papilloma with positive p16Ink4a expression in a 72‐year‐old male smoker. The 20 mm sized tumor was histologically diagnosed as mixed papilloma following right upper lobectomy. Immunohistochemically, cytokeratin 5 an...
Source: Pathology International - May 1, 2017 Category: Pathology Authors: Ryo Miyoshi, Toshi Menju, Akihiko Yoshizawa, Hiroshi Date Tags: Case Report Source Type: research
Primary malignant pericardial sarcomatoid mesothelioma: An autopsy report
We present an autopsy case in an 80‐year‐old man admitted for heart failure after one month of treatment at an outpatient clinic. He died three months after symptom onset. A complete autopsy revealed localization of the tumor to the pericardium without other lesions. Histologically, mainly spindle‐shaped atypical cells with hyperchromatic nuclei and nucleoli were observed. Immunohistochemical markers for mesothelioma were positive for calretinin, cytokeratin AE1/AE3, and cytokeratin CAM5.2. Thus, we diagnosed primary sarcomatoid malignant mesothelioma of the pericardium. To our knowledge, only four PMPSM cases have b...
Source: Pathology International - May 1, 2017 Category: Pathology Authors: Hiroko Muta, Yasuo Sugita, Koichi Ohshima, Hitoshi Otsubo Tags: Case Report Source Type: research
Corrigendum
(Source: Pathology International)
Source: Pathology International - April 3, 2017 Category: Pathology Tags: Corrigendum Source Type: research
Abstracts of Presentation by the winners of The Japanese Society of Pathology; Japan Pathology Award in 2017 (in program order)
(Source: Pathology International)
Source: Pathology International - April 3, 2017 Category: Pathology Tags: Abstract Source Type: research
Striated duct adenoma presenting with intra ‐tumoral hematoma and papillary thyroid carcinoma‐like histology
Striated duct adenoma of the salivary gland is a rare benign tumor characterized by unilayered duct epithelium and striations of the tumor cell membranes. To the best of our knowledge, only six cases have been reported in the literature. Here we report an additional case, which was complicated by an intra‐tumoral hematoma on clinical presentation and by papillary thyroid carcinoma‐like histology on intra‐operative frozen section diagnosis. An asymptomatic 78‐year‐old male presented with a two‐year‐history of a painless tumor of the left parotid. An intra‐tumoral hematoma, which is unusual for a salivary gla...
Source: Pathology International - April 1, 2017 Category: Pathology Authors: Yohei Ito, Kana Fujii, Takayuki Murase, Kosuke Saida, Yoshihide Okumura, Hisashi Takino, Ayako Masaki, Shintaro Beppu, Daisuke Kawakita, Kei Ijichi, Hiroshi Inagaki Tags: Case Report Source Type: research
Cellular retinoic acid bioavailability in various pathologies and its therapeutic implication
Retinoic acid (RA), an active metabolite of vitamin A, is a critical signaling molecule in various cell types. We found that RA depletion caused by expression of the RA‐metabolizing enzyme CYP26A1 promotes carcinogenesis, implicating CYP26A1 as a candidate oncogene. Several studies of CYP26s have suggested that the biological effect of RA on target cells is primarily determined by “cellular RA bioavailability”, which is defined as the RA level in an individual cell, rather than by the serum concentration of RA. Consistently, stellate cells store approximately 80% of vitamin A in the body, and the state of cellular RA...
Source: Pathology International - April 1, 2017 Category: Pathology Authors: Makoto Osanai Tags: Review Source Type: research
A case of solitary pulmonary capillary hemangioma indicating true gross appearance
(Source: Pathology International)
Source: Pathology International - April 1, 2017 Category: Pathology Authors: Hirotsugu Hashimoto, Masahiro Yanagiya, Yoshio Suzuki, Masashi Kusakabe, Genki Usui, Jun Matsumoto, Hajime Horiuchi Tags: Letter to the Editor Source Type: research
Pathogenetic significance and possibility as a therapeutic target of platelet derived growth factor
Platelet‐derived growth factor (PDGF) is one of the major mitogens and chemoattractants for mesenchymal and glial cells. Nowadays, the expression of PDGFs are recognized widely in our body, and emerging data indicate the relevance of PDGFs in the homeostatic control of systemic connective tissue as well as parenchymal cells such as neurons. Aberrant PDGF signal is primarily tumorigenic, and also regulates tumor microenvironments. The roles of the PDGF signal in tumorigenesis are diverse depending on the type of cancer, and anti‐PDGF therapy needs to be carefully designed based on the information of each tumor cell type...
Source: Pathology International - April 1, 2017 Category: Pathology Authors: Yoko Ishii, Takeru Hamashima, Seiji Yamamoto, Masakiyo Sasahara Tags: Review Article Source Type: research
Clinical and pathological significance of myeloid differentiation factor 88 expression in human hepatocellular carcinoma tissues
In this study, MyD88 expression was examined in 105 samples of human hepatocellular carcinoma (HCC) tissue by immunohistochemistry, Western blot, and quantitative reverse‐transcriptase polymerase chain reaction methods. The relationships between MyD88 expression and clinical and pathological parameters were analyzed. The results showed that attenuated expression of MyD88 in HCC tissue tumor cells was significantly related to hepatitis B virus infection, large tumor size, positive vascular invasion, and intrahepatic metastasis (P < 0.05). Western blot analysis of MyD88 protein in nine normal livers and 28 HCCs show...
Source: Pathology International - April 1, 2017 Category: Pathology Authors: Keiichi Kinowaki, Yurie Soejima, Arisa Kumagai, Fukuo Kondo, Keiji Sano, Takeshi Fujii, Masanobu Kitagawa, Toshio Fukusato Tags: Original Article Source Type: research
Renal angiomyolipoma with para ‐aortic lymph node involvement
(Source: Pathology International)
Source: Pathology International - March 7, 2017 Category: Pathology Authors: Koto Kon ‐Nanjo, Youichiro Baba, Yuko Yoshio, Ryuichi Suzuki, Tomio Araki, Tetsuya Murata Tags: Letter To The Editor Source Type: research
A case of ovarian steroid cell tumor with bizarre nuclear atypia and CTNNB1 mutation
(Source: Pathology International)
Source: Pathology International - March 7, 2017 Category: Pathology Authors: Masaki Suzuki, Jun Matsushima, Takuya Yazawa, Satoshi Ota, Takako Kiyokawa, Hiroki Sonehara, Shinsuke Hanawa, Akira Mitsuhashi, Makio Shozu, Yukio Nakatani Tags: Letter to the Editor Source Type: research
A case of primary aldosteronism caused by unilateral multiple adrenocortical micronodules presenting as muscle cramps at rest: The importance of functional histopathology for identifying a culprit lesion
Unilateral multiple adrenocortical micronodules (UMNs) constitute a rare subset of primary aldosteronism (PA) characterized by the hypersecretion of aldosterone derived from multiple small nodules in the zona glomerulosa of the unilateral adrenal grand. This case study describes a 49‐year‐old man with PA and UMNs who presented with muscle cramps at rest due to hypokalemia. The patient had a 6‐year history of hypertension treated with antihypertensive drugs. Imaging studies revealed bilateral adrenal nodules as large as 5 mm. Adrenal venous sampling confirmed unilateral PA; therefore, the patient underwent the remov...
Source: Pathology International - March 4, 2017 Category: Pathology Authors: Atsushi Ito, Yuto Yamazaki, Hironobu Sasano, Daisuke Matsubara, Noriyoshi Fukushima, Mio Tamba, Kenichi Tabata, Kentaro Ashizawa, Akihito Takei, Masaru Koizumi, Yasunaru Sakuma, Naohiro Sata, Hisashi Oshiro Tags: Case Report Source Type: research
