The PD ‐1/PD‐L1 axis may be aberrantly activated in occupational cholangiocarcinoma
This study examined the expression status of programmed death‐1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) in occupational cholangiocarcinoma. Immunostaining of PD‐1, PD‐L1, CD3, CD8, and CD163 was performed using tissue sections of occupational cholangiocarcinoma (n = 10), and the results were compared with those of control cases consisting of intrahepatic (n = 23) and extrahepatic (n = 45) cholangiocarcinoma. Carcinoma cells expressed PD‐L1 in all cases of occupational cholangiocarcinoma, whereas the detection of PD‐L1 expression in cholangiocarcinoma cells was limited to a low number of cas...
Source: Pathology International - December 31, 2016 Category: Pathology Authors: Yasunori Sato, Masahiko Kinoshita, Shigekazu Takemura, Shogo Tanaka, Genya Hamano, Shoji Nakamori, Masahiro Fujikawa, Yasuhiko Sugawara, Takatsugu Yamamoto, Akira Arimoto, Minako Yamamura, Motoko Sasaki, Kenichi Harada, Yasuni Nakanuma, Shoji Kubo Tags: Original Article Source Type: research
High expression of Wls is associated with lymph node metastasis and advanced TNM stage in gastric carcinomas
In this study, three gastric cancer cell lines MGC‐803, SGC‐7901, and AGS, and a set of gastric carcinoma tissue specimens were subjected to immunohistochemistry. The relationship between the expression of Wls and clinicopathological parameters was analyzed. Wls was negatively detected in MGC‐803, positively detected in SGC‐7901 and AGS cell lines. Wls was weakly expressed in 9.7% (15/154), moderately in 33.1% (51/154), and strongly in 57.1% (88/154) of tested gastric carcinoma specimens. High expression of Wls was positively associated with well and moderately differentiated tumors (P = 0.035, rs = 0.170),...
Source: Pathology International - December 31, 2016 Category: Pathology Authors: Wei Zhang, Hong Tao, Xiao Chen, Haruhiko Sugimura, Jiandong Wang, Ping Zhou Tags: Original Article Source Type: research
Epigenetic regulation of Wnt/ β‐catenin signal‐associated genes in gastric neoplasia of the fundic gland (chief cell‐predominant) type
In conclusion, our results suggest that activation of this pathway, mediated by gene methylation, may be associated with progression of some GNCCP cases, similar to CGAs. (Source: Pathology International)
Source: Pathology International - December 31, 2016 Category: Pathology Authors: Takashi Murakami, Hiroyuki Mitomi, Takashi Yao, Tsuyoshi Saito, Tomoyoshi Shibuya, Sumio Watanabe Tags: Original Article Source Type: research
Bcl ‐2 family in non‐small cell lung cancer: its prognostic and therapeutic implications
Non‐small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. Despite significant advances in its research of tumor biology and therapy, the prognosis for this neoplasm has still remained poor. The great majority of anticancer agents, regardless of their mechanisms of action, exert their lethal actions on cancer cells by inducing apoptosis following drug‐induced cellular damage. Many reported studies have evaluated the prognostic and therapeutic implications of apoptosis in lung cancer, but their exact clinical value has remained unclear. Therefore more prospective studies are currently require...
Source: Pathology International - December 31, 2016 Category: Pathology Authors: Ping ‐Li Sun, Hironobu Sasano, Hongwen Gao Tags: Review Article Source Type: research
A case of anaplastic lymphoma kinase (ALK) ‐positive ciliated muconodular papillary tumor (CMPT) of the lung
We report a case of CMPT involving the rearrangement of the anaplastic lymphoma kinase (ALK) gene. The patient was an 84‐year‐old Japanese female who had exhibited a small nodular shadow on chest computed tomography during a regular checkup 10 years ago. She underwent a partial resection of segment S10 of the right lung. The cut surface of the surgical specimen revealed a well‐circumscribed, jelly‐like mass measuring 8 × 8 × 10 mm. Histologically, the tumor was composed of a mixture of ciliated, goblet, and basal cells arranged in a papillary pattern together with pools of mucin. A diagnosis of CMPT was made. T...
Source: Pathology International - December 31, 2016 Category: Pathology Authors: Ryo Taguchi, Kayoko Higuchi, Motohiro Sudo, Kenji Misawa, Takashi Miyamoto, Osamu Mishima, Morihisa Kitano, Koji Azuhata, Nobuo Ito Tags: Case Report Source Type: research
Re ‐evaluation of Phenotypic Expression in Differentiated‐type Early Adenocarcinoma of the Stomach
In conclusion, CDX2 was a sensitive marker for assessing intestinal phenotype. A large portion of the early differentiated‐type adenocarcinomas expressed CDX2 from the very early stage of carcinogenesis, and the proportion of G‐type was unexpectedly low. Lower expression of each phenotype marker was considered the cause of phenotype alteration during submucosal invasion. (Source: Pathology International)
Source: Pathology International - December 31, 2016 Category: Pathology Authors: Masato Hayakawa, Ken Nishikura, Yoichi Ajioka, Yutaka Aoyagi, Shuji Terai Tags: Original Article Source Type: research
A typical presentation of primary pulmonary epithelioid sarcoma misdiagnosed as non ‐small cell lung cancer
(Source: Pathology International)
Source: Pathology International - December 31, 2016 Category: Pathology Authors: Makoto Emori, Mitsuharu Tamakawa, Mitsunori Kaya, Kohichi Takada, Kazuyuki Murase, Chisa Fujita, Sayuri Sato, Ryuji Takahashi, Kanako C. Hatanaka, Shintaro Sugita, Hiroshi Hirano, Toshihiko Yamashita, Tadashi Hasegawa Tags: Letter to the Editor Source Type: research
Protein induced by vitamin K absence or antagonist II (PIVKA ‐II) producing large cell neuroendocrine carcinoma (LCNEC) of lung with multiple liver metastases: A case report
A 78‐year‐old man was admitted to our hospital for multiple lung and liver tumors. Initial clinical diagnosis was hepatocellular carcinoma (HCC) with lung metastases because of a high value of serum protein induced by vitamin K absence or antagonist II (PIVKA‐II) (6,705 mAU/mL). However, a review of a prior CT showed the lung tumor had existed 6 months before liver tumors were detected. The tumors progressed rapidly and the patient died 37 days after admission. Autopsy revealed that both lung and liver tumors exhibited the histology of large cell neuroendocrine carcinoma (LCNEC). Immunohistochemistry revealed that ...
Source: Pathology International - December 31, 2016 Category: Pathology Authors: Hirokazu Kurohama, Yumi Mihara, Yasumori Izumi, Masatsugu Kamata, Seiji Nagashima, Atsumasa Komori, Yojiro Matsuoka, Nozomi Ueki, Masahiro Nakashima, Masahiro Ito Tags: Case Report Source Type: research
Double immunostaining for maspin and p53 on cell blocks increases the diagnostic value of biliary brushing cytology
In conclusion, Maspin/p53 double immunostaining on cell blocks contributes to the detection of malignant cells in biliary brushing cytology specimens. (Source: Pathology International)
Source: Pathology International - December 31, 2016 Category: Pathology Authors: Maki Kanzawa, Tsuyoshi Sanuki, Manabu Onodera, Kohei Fujikura, Tomoo Itoh, Yoh Zen Tags: Original Article Source Type: research
The eight year evolution of an osseous PEComa
(Source: Pathology International)
Source: Pathology International - December 31, 2016 Category: Pathology Authors: Georgia Karpathiou, Fabrice Guy Barral, Cyril Habougit, Vanessa Da Cruz, Fabien Forest, Olivier Collard, Michel Peoc'h Tags: Letter to the Editor Source Type: research
An autopsy case of hyperthyroid cardiomyopathy manifesting lethal congestive heart failure
(Source: Pathology International)
Source: Pathology International - December 22, 2016 Category: Pathology Authors: Makoto Sano, Taku Homma, Toshiyuki Ishige, Nami Sawada, Shingo Ihara, Kosaku Kinoshita, Shinobu Masuda, Hiroyuki Hao Tags: Letter to the Editor Source Type: research
Pleuroparenchymal fibroelastosis with prominent thrombosis
(Source: Pathology International)
Source: Pathology International - December 19, 2016 Category: Pathology Authors: Kimberly von der Oord, Heleen Rietema, Jan H. von der Thusen, Eric Thunnissen Tags: Letter to the Editor Source Type: research
Pathological findings of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease
(Source: Pathology International)
Source: Pathology International - December 19, 2016 Category: Pathology Authors: Michiie Sakamoto, Hanako Tsujikawa, Kathryn Effendi, Hidenori Ojima, Kenichi Harada, Yoh Zen, Fukuo Kondo, Masayuki Nakano, Masayoshi Kage, Yoshio Sumida, Etsuko Hashimoto, Gotaro Yamada, Takeshi Okanoue, Kazuhiko Koike Tags: Editorial Source Type: research
How to confirm or deny high ‐risk thyroid carcinoma is a challenge for pathologists
(Source: Pathology International)
Source: Pathology International - December 19, 2016 Category: Pathology Authors: Kennichi Kakudo, Masami Asai, Yanhua Bai Tags: Letter to the Editor Source Type: research
GLUT1: A novel tool reflecting proliferative activity of lung neuroendocrine tumors?
Lung neuroendocrine tumors (LNT) represents approximately 20% of all lung cancers. The classification of LNT relies upon morphology. Recently, in the World Health Organization (WHO) classification, Ki‐67 rate has been proposed for classification. It is, however, known that Ki‐67 count has a poor interlaboratory reproducibly. For that reason, our team has looked for a new biomarker. GLUT1 protein a facilitative glucose transporter protein which has ubiquitous expression in mammalian. GLUT1 is overexpressed in many human cancers. But, no study has evaluated the GLUT1 staining as an aid diagnosis in LNT. Our team have ass...
Source: Pathology International - December 19, 2016 Category: Pathology Authors: Nazim Benzerdjeb, Pascal Berna, Henri Sevestre Tags: Original Article Source Type: research
