Sporadic minute medullary thyroid carcinoma with a double RET mutation: A case report

This study reports the smallest case of sporadic MTC with a double RET somatic mutation, substantiating that RET mutations can occur during a very early stage of carcinogenesis. The combined presence of C630R and C634W represent a novel somatic mutation in sporadic MTC. The present case indicates that the sporadic MTC originated from the surrounding C‐cells of the SCNs without C‐cell hyperplasia and that the SCN main cells may not be able to develop into an MTC.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fpin.12588

Source: Pathology International - September 1, 2017 Category: Pathology Authors: Hiroyuki Yamamoto, Jun Ishii, Tomohiro Chiba, Yoko Nakazato, Kouichi Hirano, Hiroshi Kamma Tags: Case Report Source Type: research