Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection
Summary
African trypanosomosis is a debilitating parasitic disease occurring in large parts of sub‐Saharan Africa. Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing disease. Multiple experimental murine models for trypanosomosis have demonstrated inflammation‐dependent apoptosis of splenic follicular B (FoB) cells and the destruction of B‐cell memory against previously encountered pathogens. Here, we report that during murine infection with a chronic T. b. gambiense field isolate, FoB cells are retained. This coincided with reduced levels of IFN...
Source: Parasite Immunology - July 27, 2016 Category: Parasitology Authors: J. Cnops, F. Kauffmann, C. De Trez, T. Baltz, J. Keirsse, M. Radwanska, E. Muraille, S. Magez Tags: Brief Definitive Report Source Type: research
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Source: Parasite Immunology - July 25, 2016 Category: Parasitology Authors: Una Ryan, Alireza Zahedi, Andrea Paparini Tags: Commissioned Review or Articles Source Type: research
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Source: Parasite Immunology - July 18, 2016 Category: Parasitology Authors: Natalie Nieuwenhuizen Tags: Commissioned Review or Article Source Type: research
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This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - July 17, 2016 Category: Parasitology Authors: Vanessa O. Ezenwa Tags: Commissioned Review or Article Source Type: research
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This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - July 17, 2016 Category: Parasitology Authors: Vanessa O. Ezenwa Tags: Commissioned Review or Article Source Type: research
