Signalling pathways associated with IL ‐6 production and epithelial–mesenchymal transition induction in prostate epithelial cells stimulated with Trichomonas vaginalis
Summary
Trichomonas vaginalis (Tv) has been found in patient tissue of benign prostatic hyperplasia (BPH), and suggested to cause chronic prostatitis. IL‐6 is known as one of the important factors of chronic inflammation in prostate cancer. Patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) had higher levels of IL‐6 in seminal plasma. Furthermore, inflammatory conditions induced by pathogen infections have been shown to promote epithelial–mesenchymal transition (EMT). Here, we investigated the signals involved in IL‐6 production by human prostate epithelial cells (PECs) stimulated with Tv and ...
Source: Parasite Immunology - October 3, 2016 Category: Parasitology Authors: I. H. Han, J. H. Kim, S. S. Kim, M. H. Ahn, J. S. Ryu Tags: Original Paper Source Type: research
Small RNAs and extracellular vesicles in filarial nematodes: from nematode development to diagnostics
This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - September 30, 2016 Category: Parasitology Authors: Juan F. Quintana, Simon A. Babayan, Amy H. Buck Tags: Commissioned Review or Article Source Type: research
Mucosal and systemic immune modulation by Trichuris trichiura in a self ‐infected individual
This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - September 30, 2016 Category: Parasitology Authors: Anders Dige, Tue Kruse Rasmussen, Peter Nejsum, Rikke Hagemann ‐Madsen, Andrew R. Williams, Jørgen Agnholt, Jens F Dahlerup, Christian L Hvas Tags: Original Paper Source Type: research
Protective Role of IL ‐22 against Schistosoma mansoni Soluble Egg Antigen‐ Induced Granuloma in Vitro
Conclusion, IL‐17 accelerates SEA‐induced granuloma formation and inhibits granulocytes functions in Schistosoma‐infected patients, while IL‐22 inhibited the granuloma formation, but enhanced granulocyte functions.
This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - September 30, 2016 Category: Parasitology Authors: Soad Nady, Mohamed Tarek M. Shata, Mohammad A. Mohey, Ayatollah El ‐Shorbagy Tags: Original Paper Source Type: research
Progress in the development of subunit vaccines for gastrointestinal nematodes of ruminants
This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - September 30, 2016 Category: Parasitology Authors: J. B. Matthews, P. Geldhof, T. Tzelos, E. Claerebout Tags: Commissioned Review or Article Source Type: research
Parasites, microbiota and metabolic disease
This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - September 30, 2016 Category: Parasitology Authors: Sonakshi Bhattacharjee, Nils Kalbfuss, Clarissa Prazeres da Costa Tags: Commissioned Review or Article Source Type: research
Corrigendum
(Source: Parasite Immunology)
Source: Parasite Immunology - September 28, 2016 Category: Parasitology Tags: Corrigendum Source Type: research
Host Th1/Th2 immune response to Taenia solium cyst antigens in relation to cyst burden of neurocysticercosis
This study examined ex vivo CD4+ T cells and in vitro Th1 and Th2 cytokine responses to T. solium cyst antigens of peripheral blood mononuclear cells of healthy subjects from endemic and nonendemic regions and of single‐ and multicyst‐infected patients for association with cyst burden of NCC. T. solium cyst antigens elicited a Th1 cytokine response in healthy subjects of T. solium‐endemic and T. solium‐non‐endemic regions and those with single‐cyst infections and a Th2 cytokine response from subjects with multicyst neurocysticercosis. Multicyst neurocysticercosis subjects also exhibited low levels of effect...
Source: Parasite Immunology - September 28, 2016 Category: Parasitology Authors: J. Tharmalingam, A. T. Prabhakar, P. Gangadaran, P. Dorny, J. Vercruysse, P. Geldhof, V. Rajshekhar, M. Alexander, A. Oommen Tags: Original Article Source Type: research
Issue Information
(Source: Parasite Immunology)
Source: Parasite Immunology - September 28, 2016 Category: Parasitology Tags: Issue Information Source Type: research
Immunogenomics of gastrointestinal nematode infection in ruminants – breeding for resistance to produce food sustainably and safely
Summary
Gastrointestinal nematode (GIN) infection of ruminants represents a major health and welfare challenge for livestock producers worldwide. The emergence of anthelmintic resistance in important GIN species and the associated animal welfare concerns have stimulated interest in the development of alternative and more sustainable strategies aimed at the effective management of the impact of GINs. These integrative strategies include selective breeding using genetic/genomic tools, grazing management, biological control, nutritional supplementation, vaccination and targeted selective treatment. In this review, the logic o...
Source: Parasite Immunology - September 20, 2016 Category: Parasitology Authors: T. Sweeney, J. P. Hanrahan, M. T. Ryan, B. Good Tags: Commissioned Review Article Source Type: research
Anisakis – immunology of a foodborne parasitosis
Summary
Anisakis species are marine nematodes which can cause zoonotic infection in humans if consumed in raw, pickled or undercooked fish and seafood. Infection with Anisakis is associated with abdominal pain, nausea and diarrhoea and can lead to massive infiltration of eosinophils and formation of granulomas in the gastrointestinal tract if the larvae are not removed. Re‐infection leads to systemic allergic reactions such as urticarial or anaphylaxis in some individuals, making Anisakis an important source of hidden allergens in seafood. This review summarizes the immunopathology associated with Anisakis infection. Ani...
Source: Parasite Immunology - September 20, 2016 Category: Parasitology Authors: Natalie E. Nieuwenhuizen Tags: Commissioned Review Article Source Type: research
Cryptosporidium in humans and animals —a one health approach to prophylaxis
Summary
Cryptosporidium is a major cause of moderate‐to‐severe diarrhoea in humans worldwide, second only to rotavirus. Due to the wide host range and environmental persistence of this parasite, cryptosporidiosis can be zoonotic and associated with foodborne and waterborne outbreaks. Currently, 31 species are recognized as valid, and of these, Cryptosporidium hominis and Cryptosporidium parvum are responsible for the majority of infections in humans. The immune status of the host, both innate and adaptive immunity, has a major impact on the severity of the disease and its prognosis. Immunocompetent individuals typicall...
Source: Parasite Immunology - September 20, 2016 Category: Parasitology Authors: U. Ryan, A. Zahedi, A. Paparini Tags: Commissioned Review Article Source Type: research
Helminth –microparasite co‐infection in wildlife: lessons from ruminants, rodents and rabbits
Summary
Co‐infection is now recognized as the natural state of affairs in most hosts and co‐infecting parasites interact in a variety of ways that can impact host health and parasite fitness. Interactions between helminths and microparasites have captured particular attention in this regard owing to the ubiquity of helminth infections in many host populations. The mechanistic underpinnings and health implications of co‐infection are typically studied in laboratory and clinical settings, but recently studies of wild species have begun to tackle similar issues. Case studies from three wild mammal groups—ruminants, ro...
Source: Parasite Immunology - September 20, 2016 Category: Parasitology Authors: V. O. Ezenwa Tags: Commissioned Review Article Source Type: research
Editorial —One Health Special Issue—Parasite Immunology
(Source: Parasite Immunology)
Source: Parasite Immunology - September 20, 2016 Category: Parasitology Authors: G. Mulcahy Tags: Commissioned Review Article Source Type: research
Issue Information
(Source: Parasite Immunology)
Source: Parasite Immunology - September 20, 2016 Category: Parasitology Tags: Issue Information Source Type: research
