Treating murine Kala Azar with a Mayan plant induces immunochemical changes
ConclusionsP. andrieuxii root extract is an affordable phytomedicine to treat experimental Kala Azar in Balb/c mice.This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - October 1, 2017 Category: Parasitology Authors: C. M Lezama ‐Dávila, A. P Isaac‐Márquez Tags: Original Paper Source Type: research
Protease ‐activated receptor 2 contributes to Toxoplasma gondii‐mediated gut inflammation
Summary
Toxoplasma gondii is a widespread intracellular parasite, which naturally enters the organism via the oral route and crosses the intestinal barrier to disseminate. In addition to neuronal and ocular pathologies, this pathogen also causes gut inflammation in a number of animals. This infection‐triggered inflammation has been extensively studied in the C57BL/6 mice, highlighting the importance of the immune cells and their mediators in the development of gut pathology. However, despite their importance in inflammation, the role of protease‐activated receptors (PAR) was never reported in the context of T.gondii‐...
Source: Parasite Immunology - September 27, 2017 Category: Parasitology Authors: C. Bonnart, G. Feuillet, V. Vasseur, N. Cenac, N. Vergnolle, N. Blanchard Tags: ORIGINAL ARTICLE Source Type: research
Leishmania tarentolae expressing CXCL ‐10 as an efficient immunotherapy approach against Leishmania major‐infected BALB/c mice
This study was undertaken to investigate the therapeutic effects of recombinant Leishmania tarentolae expressing CXCL‐10 and an expression vector encoding CXCL‐10 (pcDNA‐CXCL‐10‐EGFP) in a model of BALB/c mice susceptible to infection by Leishmania major. The outcome of intervention was examined at 3 weeks post‐treatment by evaluating the parameters of parasite burden (PB), arginase activity, NO and various cytokines such as IFN‐γ, IL‐4, IL‐6 and IL‐10. The results have shown that despite the efficacy of CXCL‐10 expression vector as gene therapy, the live therapy strategy using L. tarentolae expres...
Source: Parasite Immunology - September 20, 2017 Category: Parasitology Authors: H. Montakhab ‐Yeganeh, Z. Abdossamadi, F. Zahedifard, Y. Taslimi, A. Badirzadeh, N. Saljoughian, T. Taheri, M. Taghikhani, S. Rafati Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Parasite Immunology)
Source: Parasite Immunology - September 20, 2017 Category: Parasitology Tags: ISSUE INFORMATION Source Type: research
Induction of heme oxygenase ‐1 increases infection of dog macrophages by L. infantum
ConclusionInduction of HO‐1 metabolism in dogs infected by L. infantum is possibly one of the mechanisms responsible for increasing the infection of macrophages, mainly through reduction of the oxidative and nitrosative metabolisms of these cells.This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - September 20, 2017 Category: Parasitology Authors: Breno Fernando Martins Almeida, Kathlenn Liezbeth Oliveira Silva, Gabriela Lovizutto Venturin, Vanessa Marim Chiku, Aline Aparecida Correa Leal, Anelise Maria Bosco, Paulo Cesar Ciarlini, Val éria Marçal Felix Lima Tags: Original Article Source Type: research
Effect of ES products from Anisakis (Nematoda: Anisakidae) on experimentally induced colitis in adult zebrafish
This study therefore dissects to what extent a series of immune‐related genes are modulated in zebrafish with experimentally induced colitis following exposure to excretory‐secretory (ES) products isolated from larval Anisakis, a widely distributed fish nematode. Adult zebrafish intrarectally exposed to the colitis‐inducing agent TNBS developed severe colitis leading to 80% severe morbidity, but if co‐injected (ip) with Anisakis ES products, the morbidity rate was 50% at the end of the experiment (48 hours post‐exposure). Gene expression studies of TNBS‐treated zebrafish showed clear upregulation of a range of...
Source: Parasite Immunology - September 5, 2017 Category: Parasitology Authors: S. Haarder, P. W. Kania, T. L. Holm, L. von Gersdorff J ørgensen, K. Buchmann Tags: ORIGINAL ARTICLE Source Type: research
Dog skin parasite load, TLR ‐2, IL‐10 and TNF‐α expression and infectiousness
This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - September 1, 2017 Category: Parasitology Authors: Dandara Camila Morais Pereira ‐Fonseca, Fernanda Muller Oliveira‐Rovai, Lílian Aparecida Colebrusco Rodas, Carolina Aparecida Carlin Beloti, Rafaela Beatriz Pintor Torrecilha, Píer Kenji Rauschkolb Katsuda Ito, Saulo Vinícius Avanço, Rafael Silva Tags: Original Article Source Type: research
Pegylation of Cationic Liposomes Encapsulating Soluble Leishmania Antigens (SLA) Reduces the Adjuvant Efficacy of Liposomes in Murine Model
This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - September 1, 2017 Category: Parasitology Authors: Hadi Naseri, Faezeh Eskandari, Mahmoud Reza Jaafari, Ali Khamesipour, Azam Abbasi, Ali Badiee Tags: Original Paper Source Type: research
Total Leishmania antigens with Poly(I:C) induce Th1 protective response
ConclusionOur findings demonstrate a promising vaccine against cutaneous leishmaniasis that is relatively economic and easy to develop and which should be taken into account for preventing leishmaniasis in developing countries.This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - September 1, 2017 Category: Parasitology Authors: Maria Victoria Sanchez, Ricardo Javier Eli çabe, María Silvia Di Genaro, María José Germanó, Susana Gea, María Fernanda García Bustos, María Cristina Salomón, Eduardo Alberto Scodeller, Diego Esteban Cargnelutti Tags: Brief Definitive Report Source Type: research
Triggering immunological memory against the tapeworm Hymenolepis diminuta to protect against colitis
ConclusionAn additional approach to managing inflammatory disease could be infection with H. diminuta followed by eliciting anti‐worm recall responses.This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - September 1, 2017 Category: Parasitology Authors: Arthur Wang, Toshio Arai, Alec Campbell, Jose Luis Reyes, Fernando Lopes, Derek M. McKay Tags: Original Paper Source Type: research
Protease ‐Activated Receptor 2 contributes to Toxoplasma gondii–mediated gut inflammation
This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - September 1, 2017 Category: Parasitology Authors: Chrystelle Bonnart, Guyl ène Feuillet, Virginie Vasseur, Nicolas Cenac, Nathalie Vergnolle, Nicolas Blanchard Tags: Original Article Source Type: research
Anti ‐schistosome antibodies change NTPDase 1 activity from macrophages
This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - August 31, 2017 Category: Parasitology Authors: Danielle Gomes Marconato, Mich élia Antônia do Nascimento Gusmão, Juliana Melo, Juciane Maria de Andrade Castro, Gilson Costa Macedo, Eveline Gomes Vasconcelos, Priscila de Faria‐Pinto Tags: Original Paper Source Type: research
Evaluation of gene expression levels for cytokines in ocular toxoplasmosis
This study evaluated levels for mRNA expression of 7 cytokines in ocular toxoplasmosis. Peripheral blood mononuclear cells (PBMC) of ocular toxoplasmosis patients (OT Group, n= 23) and chronic toxoplasmosis individuals (CHR Group, n= 9) were isolated and stimulated in vitro with T. gondii antigen. Negative controls (NC) were constituted of 7 PBMC samples from individuals seronegative for toxoplasmosis. mRNA expression for cytokines was determined by qPCR. Results showed a significant increase of mRNA levels from antigen stimulated PBMCs derived from OT Group for expressing IL‐6 (at p<0.005 and p < 0.0005 for CHR an...
Source: Parasite Immunology - August 24, 2017 Category: Parasitology Authors: Marta Marques Maia, Cristina Silva Meira ‐Strejevitch, Vera Lucia Pereira‐Chioccola, Daise Damaris Carnietto de Hippólito, Valéria Oliveira Silva, Cinara Cássia Brandão de Mattos, Fábio Batista Frederico, Rubens Camargo Siqueira, Luiz Carlos de M Tags: Original Paper Source Type: research
Leishmania tarentolae expressing CXCL ‐10 as an efficient immunotherapy approach against L. major‐infected BALB/c mice
This article is protected by copyright. All rights reserved. (Source: Parasite Immunology)
Source: Parasite Immunology - August 18, 2017 Category: Parasitology Authors: Hossein Montakhab ‐Yeganeh, Zahra Abdossamadi, Farnaz Zahedifard, Yasaman Taslimi, Alireza Badirzadeh, Noushin Saljoughian, Tahereh Taheri, Mohammad Taghikhani, Sima Rafati Tags: Original Paper Source Type: research
Ascaris suum infection modulates inflammation: Implication of CD4+ CD25high Foxp3+ T cells and IL ‐10
In conclusion, our results demonstrated that A. suum experimental infection was capable of suppressing LPS‐induced inflammation by mechanisms, which seem to be dependent on responses of CD4+ CD25+ T cells and secretion of IL‐10 cytokine. (Source: Parasite Immunology)
Source: Parasite Immunology - August 18, 2017 Category: Parasitology Authors: T. de O. Titz, C. A. A. Ara újo, C. S. Enobe, P. O. Rigato, T. M. Oshiro, M. F. Macedo‐Soares Tags: ORIGINAL ARTICLE Source Type: research
