Asthma in Olympians
High prevalence of asthma has been reported repeatedly among elite athletes, especially among endurance athletes. So many athletes used asthma drugs that the objective demonstration of bronchial hyperresponsiveness was required to obtain approval for their use in international sports until 2012 when the most used inhaled asthma drugs was allowed for free use, but with a maximum dose for inhaled β2-agonists.Several factors contribute to the development of asthma among the Olympians causing airways inflammation and bronchial hyper-responsiveness: (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - November 26, 2015 Category: Respiratory Medicine Authors: Kai-Håkon Carlsen Tags: Short communication Source Type: research
When to suspect primary ciliary dyskinesia in children
Primary ciliary dyskinesia [PCD] is an uncommon, autosomal dominantly inherited condition that is often overlooked and undertreated in childhood. Amidst the myriad of children with coloured nasal secretions, otitis media and a wet cough, there exists a subset with PCD as the underlying unifying diagnosis. In this paper we have highlighted the varying clinical manifestations of PCD, emphasising different presentations between neonates, toddlers, school aged children and adults. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - November 23, 2015 Category: Respiratory Medicine Authors: Dominic A. Fitzgerald, Adam J. Shapiro Source Type: research
Question 7: For an infant with an equivocal sweat chloride following newborn screening, how likely is a diagnosis of cystic fibrosis?
(Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - November 23, 2015 Category: Respiratory Medicine Authors: Tyler Groves, Paul Robinson, Dominic A. Fitzgerald Source Type: research
Question 7: For an infant with an equivocal sweat chloride following newborn screening, how likely is a diagnosis of cystic fibrosis?
Identification of elevated immunoreactive trypsinogen (IRT) on newborn screening (NBS) precedes follow-up genetic and sweat chloride testing to correctly identify infants with cystic fibrosis (CF). A sweat chloride value of ≥ 60 mmol/L, regardless of genetic mutations, or a value of 30-59 mmol/L with 2 CF-causing mutations in the CF transmembrane conductance regulator (CFTR) gene defines cystic fibrosis. While the advent of NBS has led to improved survival in CF patients [1], it has also given rise to a cohort with d iagnostic uncertainty in 2-4% of screen positive infants [2,3]. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - November 22, 2015 Category: Respiratory Medicine Authors: Tyler Groves, Paul Robinson, Dominic A. Fitzgerald Tags: Cystic Fibrosis Frequently Asked Questions Source Type: research
That antibiotic prophylaxis should be used in children with repaired oesophageal atresia and or trachea-oesophageal fistula – The case in favour
Before we can determine whether prophylaxis with antibiotics is required in a patient with repaired Esophageal Atresia/trachea-esophageal fistula, it is appropriate to realize the impact and scope of the disorder. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - November 16, 2015 Category: Respiratory Medicine Authors: Peter J. Merkus Tags: Pro-Con Debate Source Type: research
