Question 9: What is the role for bronchoscopy and bronchoalveolar lavage in Cystic Fibrosis?
For the last twenty-five years there has been an increasing emphasis on the early detection of airway infection and inflammation, mitigation with antibiotics and anti-inflammatory therapies and prevention or slowing of the progression of bronchiectasis in cystic fibrosis. There is clear evidence that the acquisition of Pseudomonas aeruginosa in sputum is a key adverse prognostic factor in the development of bronchiectasis and thereby in life expectancy [1 –3]. Thus, the earlier detection and treatment of such airway pathogens in children who are unable to provide adequate sputum samples through the use of bronchoscopy is...
Source: Paediatric Respiratory Reviews - May 11, 2016 Category: Respiratory Medicine Authors: Dominic A. Fitzgerald Tags: Cystic Fibrosis: Frequently Asked Questions Source Type: research
Question 9: What is the role for bronchoscopy and bronchoalveolar lavage in Cystic Fibrosis?
For the last twenty-five years there has been an increasing emphasis on the early detection of airway infection and inflammation, mitigation with antibiotics and anti-inflammatory therapies and prevention or slowing of the progression of bronchiectasis in cystic fibrosis. There is clear evidence that the acquisition of Pseudomonas aeruginosa in sputum is a key adverse prognostic factor in the development of bronchiectasis and thereby in life expectancy [1–3]. Thus, the earlier detection and treatment of such airway pathogens in children who are unable to provide adequate sputum samples through the use of bronchoscopy is ...
Source: Paediatric Respiratory Reviews - May 11, 2016 Category: Respiratory Medicine Authors: Dominic A. Fitzgerald Tags: Cystic Fibrosis: Frequently Asked Questions Source Type: research
Cystic Fibrosis Frequently Asked Questions No 9: What is the role for bronchoscopy and bronchoalveolar lavage in Cystic Fibrosis?
For the last twenty-five years there has been an increasing emphasis on the early detection of airway infection and inflammation, mitigation with antibiotics and anti-inflammatory therapies and prevention or slowing of the progression of bronchiectasis in cystic fibrosis. There is clear evidence that the acquisition of Pseudomonas aeruginosa in sputum is a key adverse prognostic factor in the development of bronchiectasis and thereby in life expectancy [1–3]. Thus, the earlier detection and treatment of such airway pathogens in children who are unable to provide adequate sputum samples through the use of bronchoscopy is ...
Source: Paediatric Respiratory Reviews - May 11, 2016 Category: Respiratory Medicine Authors: Dominic A. Fitzgerald Source Type: research
Slipping Rib Syndrome: An elusive diagnosis
Slipping rib syndrome remains rarely recognized and frequently undiagnosed or misdiagnosed. Awareness of this condition may prevent extensive and unnecessary diagnostic evaluation and avoid chronic debilitating pain. Persistent lower chest and/or upper abdomen pain after analgesic treatment may suggest the possibility of this disorder. The diagnosis of this syndrome, is a clinical one, based on history and the hooking maneuver. A few cases have been published in the literature, giving no clear consensus about the treatment of this condition. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - May 11, 2016 Category: Respiratory Medicine Authors: Nelson L. Turcios Tags: Clinical Usefulness Source Type: research
Neurocognitive and behavioural outcomes following intervention for obstructive sleep apnoea syndrome in children
The obstructive sleep apnoea syndrome (OSAS) is common in children and results in several complications when untreated. Considering that children are undergoing important brain development, recent research has focused on neurocognitive and behavioural (NCB) complications of OSAS. Studies have shown that treatment of paediatric OSAS may improve a child's long-term cognitive and social potential and school performance. There is demonstrated benefit in terms of behaviour, attention, and social interactions, as well as likely improvement in cognitive abilities with academic and social achievements. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - May 11, 2016 Category: Respiratory Medicine Authors: Sofia Konstantinopoulou, Ignacio E. Tapia Source Type: research
What is the role for bronchoscopy and bronchoalveolar lavage in Cystic Fibrosis?
(Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - May 11, 2016 Category: Respiratory Medicine Authors: Dominic A. Fitzgerald Source Type: research
Hypoxic Challenge Test for airflight in children with respiratory disease
During airflight, cabins are pressurised to 8000ft (2438m) leading to an effective FiO2 of 0.15. This leads to a fall in oxygen saturation in all passengers, and especially those with underlying lung disease. The hypoxic challenge test using a body plethysmograph can predict a need for supplemental oxygen during airflight, and the process is described. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - May 10, 2016 Category: Respiratory Medicine Authors: Ian M. Balfour-Lynn Tags: Clinical usefulness Source Type: research
Question 8: How should distal intestinal obstruction syndrome [DIOS] be managed?
The underlying pathophysiology of Cystic Fibrosis (CF) is related to the abnormal function of chloride and bicarbonate transporters, secondary to mutations in the CF transmembrane conductance regulator (CFTR) gene. While much of the associated morbidity and mortality is due to pulmonary complications, improved life expectancy and late abnormal CF presentations in adulthood have given rise to an increasing awareness of patients suffering from gastrointestinal manifestations of CF [1,2]. Delayed intestinal obstruction syndrome (DIOS), formerly known as ‘meconium ileus equivalent’, describes a range of clinical conditions...
Source: Paediatric Respiratory Reviews - April 27, 2016 Category: Respiratory Medicine Authors: Tyler Groves, Andrea Kench, Shoma Dutt, Kevin Gaskin, Dominic A. Fitzgerald Tags: Cystic Fibrosis: Frequently Asked Questions Source Type: research
Surgical Treatment of Tracheobronchomalacia: A novel approach
Tracheobronchomalacia, as a whole, is likely misdiagnosed and underestimated as a cause of respiratory compromise in pediatric patients. Currently, there is no standardized approach for the overall evaluation of pediatric tracheobronchomalacia (TBM) and the concept of excessive dynamic airway collapse (EDAC); no grading score for the evaluation of severity; nor a standardized means to successfully approach TBM and EDAC. This paper describes our experience standardizing the approach to these complex patients whose backgrounds include different disease etiologies, as well as a variety of comorbid conditions. (Source: Paediat...
Source: Paediatric Respiratory Reviews - April 27, 2016 Category: Respiratory Medicine Authors: Sigrid Bairdain, David Zurakowski, Christopher W. Baird, Russell W. Jennings Tags: Mini-Symposium: Esophageal Atresia and Tracheo-esophageal Fistula Source Type: research
Question 8: How should distal intestinal obstruction syndrome [DIOS] be managed?
The underlying pathophysiology of Cystic Fibrosis (CF) is related to the abnormal function of chloride and bicarbonate transporters, secondary to mutations in the CF transmembrane conductance regulator (CFTR) gene. While much of the associated morbidity and mortality is due to pulmonary complications, improved life expectancy and late abnormal CF presentations in adulthood have given rise to an increasing awareness of patients suffering from gastrointestinal manifestations of CF [1,2]. Delayed intestinal obstruction syndrome (DIOS), formerly known as ‘meconium ileus equivalent’, describes a range of clinical conditions...
Source: Paediatric Respiratory Reviews - April 27, 2016 Category: Respiratory Medicine Authors: Tyler Groves, Andrea Kench, Shoma Dutt, Kevin Gaskin, Dominic A. Fitzgerald Tags: Cystic Fibrosis: Frequently Asked Questions Source Type: research
Cystic Fibrosis Frequently Asked Questions
(Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - April 27, 2016 Category: Respiratory Medicine Source Type: research
How should distal intestinal obstruction syndrome [DIOS] be managed?
(Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - April 27, 2016 Category: Respiratory Medicine Authors: Tyler Groves, Andrea Kench, Shoma Dutt, Kevin Gaskin, Dominic A. Fitzgerald Source Type: research
Surgical Treatment of Tracheobronchomalacia: A novel approach
Tracheobronchomalacia, as a whole, is likely misdiagnosed and underestimated as a cause of respiratory compromise in the pediatric population. Currently, there is no standardized approach for the overall evaluation of pediatric tracheobronchomalacia (TBM) and the concept of excessive dynamic airway collapse (EDAC), no grading score for the evaluation of severity, nor a standardized means to successfully approach TBM and EDAC. This paper describes our experience standardizing the approach to these complex patients whose backgrounds include different disease etiologies, as well as a variety of comorbid conditions. (Source: P...
Source: Paediatric Respiratory Reviews - April 27, 2016 Category: Respiratory Medicine Authors: Sigrid Bairdain, David Zurakowski, Christopher W. Baird, Russell W. Jennings Source Type: research
Obstructive Sleep Apnoea: Children are not little Adults
During a child's development, several important developmental physiological sleep processes occur, and, occasionally, pathological disorders occur, which results in differences between obstructive sleep apnoea (OSA) in adults and children. There are major differences in sleep and respiratory physiology as well as OSA symptoms and treatment options between children and adults. Many practitioners do not realize these differences, which results in delays in the diagnosis and treatment of OSA in children. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - April 20, 2016 Category: Respiratory Medicine Authors: Haya S. Alsubie, Ahmed S. BaHammam Tags: Review Source Type: research
