Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Palladium-103 Brachytherapy for Choroidal Melanoma in a Pregnant Woman
Uveal melanoma (UM) is a rare intraocular malignancy that affects mostly people of older age and peaks at the age of 60 years.1 However, the disease can also affect young patients. Rarely, UM occurs during pregnancy. There are a few published case reports and case series on UM in pregnancy; however, medical knowledge in this field is limited.2 –6 There is a debate as to whether pregnant woman should be treated immediately or delayed until postpartum, since the fetus will be exposed to some level of ionizing radiation.Herein, we present a case where a pregnant woman with UM was treated with (Source: Ophthalmic Surgery, La...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - May 21, 2018 Category: Opthalmology Authors: Ekaterina Semenova, MD Source Type: research

Ocular Tolerance of Contemporary Electronic Display Devices
Consumers of contemporary electronic devices have increased interactive exposure to electronic computer displays today more than ever before in the form of smartphones, handheld computer tablets, laptop and desktop computers, and televisions (Table 1). These devices are ubiquitous in practically every aspect of our daily lives in the developed world. Computer display technology has undergone a revolution in recent years with the advent and adoption of new display modalities, such as light-emitting diode (LED) and active-matrix light-emitting diode (AMOLED) type displays that are often (Source: Ophthalmic Surgery, Lasers an...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - May 21, 2018 Category: Opthalmology Authors: Andrew J. Clark, PhD Source Type: research

Foveal Avascular Zone Area Analysis in Macular Hole Before and After Surgery Using Optical Coherence Tomography Angiography
Vitrectomy for the treatment of macular hole (MH) has been widely established since 1991.1 In the late 1990s, optical coherence tomography (OCT) became available for noninvasive observations of the ocular fundus. OCT findings have contributed to the understanding of the pathogenesis of idiopathic MH, such as vitreomacular traction (VMT).2Fundus fluorescein angiography has long been the gold standard for assessing the retinal vasculature, but studies have reportedly failure of this modality to visualize segmented capillary layer.3 Recently, OCT angiography (OCTA) was developed, providing a (Source: Ophthalmic Surgery, Laser...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - May 21, 2018 Category: Opthalmology Authors: Ferdiriva Hamzah, MD Source Type: research

Subfoveal Choroidal Thickness as a Potential Predictor of Clinical Response to Stereotactic Radiotherapy for Neovascular Age-Related Macular Degeneration
Neovascular age-related macular degeneration (nAMD) is one of the leading causes of blindness in individuals older than 50 years of age in industrialized nations.1 The current gold standard for treatment involves intravitreal injections (IVIs) of drugs like aflibercept (Eylea; Regeneron, Tarrytown, NY), bevacizumab (Avastin; Genentech, South San Francisco, CA), and ranibizumab (Lucentis; Genentech, South San Francisco, CA), which primarily target the vascular endothelial growth factor A (VEGF-A).2 However, optimal treatment necessitates continual hospital review and repeated IVIs, which is (Source: Ophthalmic Surgery, Lase...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - May 21, 2018 Category: Opthalmology Authors: Mahdy Ranjbar, MD Source Type: research

Five-Year Outcomes of Surgically Treated Symptomatic Epiretinal Membranes With and Without Internal Limiting Membrane Peeling
In the United States, 30 million people between the ages of 43 years and 86 years are estimated to have an epiretinal membrane (ERM).1 The prevalence of ERM increases with age, from 1.9% among those younger than 60 years to 11.6% among those aged 70 years to 79 years.2 Although the exact pathogenesis for ERM formation is not clear, it has been postulated to be secondary to mechanical M üller cell activation from posterior vitreous detachment in idiopathic cases3 or due to glial cell proliferation with associated scar formation in secondary cases.4Many patients with ERMs remain asymptomatic. (Source: Ophthalmic Surgery, La...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - May 21, 2018 Category: Opthalmology Authors: Harris Sultan, MS, MD Source Type: research

Photodynamic Therapy-Induced Macular Hole
Macular hole (MH) formation following photodynamic therapy (PDT) with or without intravitreal injection has been reported rarely in the literature;1 –4 however, only one prior case report describes MH formation following PDT alone: a patient treated for juxtafoveal choroidal neovascularization (CNV) developed MH 20 days after PDT.1 Other authors have reported MH formation following PDT in combination with intravitreal anti-vascular endothelial growth factor (VEGF) injections with or without intravitreal steroid injections.2–4 Herein we report a case of a patient who developed MH following PDT (Source: Ophthalmic Surge...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - April 19, 2018 Category: Opthalmology Authors: Margaret A. Greven, MD Source Type: research

Pilot Evaluation of a New Surgical Technique for Persistent or Recurrent Large Macular Holes
We describe a new surgical technique for persistent or recurrent large MHs that were excluded from inverted ILM flap and temporal inverted ILM flap procedure because of previously ILM (Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye)
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - April 19, 2018 Category: Opthalmology Authors: Vito Primavera, MD, PhD Source Type: research

Rethinking Management Strategies for Proliferative Diabetic Retinopathy
Seenu M. HariprasadPractical Retina Co-EditorFor this Practical Retina column, Peter H. Tang, MD, PhD, and Diana V. Do, MD, were asked to comment on the evolving paradigm for treating diabetic retinopathy (DR).Frequent discussion takes place regarding the current management of DR (especially proliferative diabetic retinopathy [PDR]) given the recent approval of anti-vascular endothelial growth factor (VEGF) therapy for the treatment of DR without diabetic macular edema (DME). For instance, given the availability of ranibizumab (Lucentis; Genentech, South San Francisco, CA) to treat PDR, is (Source: Ophthalmic Surgery, Lase...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - April 19, 2018 Category: Opthalmology Authors: Peter H. Tang, MD, PhD Source Type: research

Longitudinal Quantification of Retinal Nonperfusion in the Macula of Eyes With Retinal Vein Occlusion Receiving Anti-VEGF Therapy: Secondary Analysis of the WAVE Randomized Trial
Retinal vein occlusion (RVO) is a major cause of vision loss and typically results from thrombosis of venous outflow.1 This blockage can lead to retinal nonperfusion (RNP), physiologic ischemia, and release of angiogenic factors including vascular endothelial growth factor-A (VEGF-A).The advent of VEGF antagonists such as ranibizumab (Lucentis; Genentech, South San Francisco, CA), aflibercept (Eylea; Regeneron, Tarrytown, NY), and bevacizumab (Avastin; Genentech, South San Francisco, CA) has revolutionized the treatment and management of RVO, with multiple clinical trials demonstrating their (Source: Ophthalmic Surgery, La...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - April 19, 2018 Category: Opthalmology Authors: William C. Ou, BS Source Type: research

Comparative Evaluation of Standard ILM Peel With Inverted ILM Flap Technique In Large Macular Holes: A Prospective, Randomized Study
A full-thickness macular hole (FTMH) is defined as an anatomic defect in the fovea featuring interruption of all neural retinal layers from internal limiting membrane (ILM) to the retinal pigment epithelium (RPE).1 The role of vitreous cortex in the pathogenesis of macular hole (MH) was better understood with the biomicroscopic observations of Gass.2 MHs have been known since the 19th century3 and were thought to be an untreatable condition until Kelly and Wendell proved the benefit of pars plana vitrectomy (PPV) combined with vitreous cortex detachment and fluid-gas exchange in a significant (Source: Ophthalmic Surgery, L...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - April 19, 2018 Category: Opthalmology Authors: S. Manasa, MD Source Type: research

High Reliability of Cone Cell Measurements With Adaptive Optics Scanning Laser Ophthalmoscopy in a Simulated Real-Life Clinical Setting
Adaptive optics scanning laser ophthalmoscopy (AO-SLO) is an imaging modality that can visualize the photoreceptor mosaic.1 The ability to quantitatively measure cone photoreceptors has attracted the attention of researchers studying a variety of retinal diseases and their response to treatments.2 –8 However, use of this technology in ophthalmology is relatively new and there is still much to learn about optimizing image acquisition and analysis to make the images reliable and clinically useful.The size of the area chosen is one important consideration for optimal imaging analysis. Various (Source: Ophthalmic Surgery, La...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - April 19, 2018 Category: Opthalmology Authors: Samaneh Davoudi, MD Source Type: research

Peripheral Vascular Abnormalities Seen by Ultra-Widefield Fluorescein Angiography in Adults With History of Prematurity: Report of Three Cases
In addition to the well-documented initial manifestations of neovascularization and traction retinal detachment, retinopathy of prematurity (ROP) may lead to late-developing complications such as vitreous hemorrhage or retinal tears arising from the abnormal vitreoretinal interface over normal or cicatrized retinal vasculature in the periphery and the posterior pole.1,2There are few reports in the literature describing cases of adults with a history of prematurity and spontaneously regressed (non-treatment requiring) ROP. These patients can present with a variety of vascular abnormalities (Source: Ophthalmic Surgery, Laser...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - April 19, 2018 Category: Opthalmology Authors: Linda Alejandra Cernichiaro-Espinosa, MD Source Type: research

Congenital Hypertrophy of the Retinal Pigment Epithelium Presenting With Secondary Choroidal Neovascularization
Congenital hypertrophy of the retinal pigment epithelium (CHRPE) is a flat, well-circumscribed hyperpigmented subretinal lesion that is usually found in the fundus periphery as an incidental asymptomatic finding.1 CHRPE involving the macula is rare.2 Herein, we report a case of CHRPE located in the macula and associated symptomatic choroidal neovascularization (CNV) that was successfully treated with intravitreal bevacizumab (Avastin; Genentech, South San Francisco, CA).A 12-year-old female was referred to the Bascom Palmer Ocular Oncology Service for evaluation of vision loss associated with (Source: Ophthalmic Surgery, L...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - April 19, 2018 Category: Opthalmology Authors: Robert B. Garoon, MD Source Type: research

Optical Coherence Tomography Angiography and Ultra-Widefield Optical Coherence Tomography in a Child With Incontinentia Pigmenti
Incontinentia pigmenti (IP) is a rare X-linked dominant disorder caused by mutation in the IKBKG gene, also called NEMO, and is often associated with classic dermatologic and dental findings.1 –3 Approximately one-third of affected patients demonstrate ocular involvement.2 Exam under anesthesia (EUA) with fluorescein angiography (FA) has been the mainstay of diagnostic evaluation to identify the disease at the earliest onset before vision-threatening complications such as retinal detach ment.Optical coherence tomography angiography (OCTA) is a noninvasive imaging method that visualizes the (Source: Ophthalmic Surgery, La...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - April 19, 2018 Category: Opthalmology Authors: Sang Jin Kim, MD, PhD Source Type: research

Variable Clinical Profile of Fovea Plana in Normal Children
Macular hypoplasia was originally reported in 1913 in subjects with albinism and is characterized by the absence of a foveal depression and presence of the ganglion cell layer in the foveola during histological examination.1,2 Macular hypoplasia has been associated with multiple systemic and ophthalmologic conditions including albinism, aniridia, persistent fetal vasculature, incontinentia pigmenti, nanophthalmos, and prematurity.2 –6 This disorder has also been reported as an isolated bilateral finding.7,8Historically, macular hypoplasia has been associated with poor visual acuity (VA) and (Source: Ophthalmic Surgery, L...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - April 19, 2018 Category: Opthalmology Authors: Victor M. Villegas, MD Source Type: research