Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Multimodal Imaging of Astrocytic Hamartomas Associated With Tuberous Sclerosis
Tuberous sclerosis complex (TSC) is an autosomal dominant multisystem disorder with highly variable findings. The prevalence has been estimated about one in 100,000.1 Retinal astrocytic hamartomas have been documented in up to 87% of individuals with TSC.2 Although their clinical appearance has been extensively described, the value of optical coherence tomography (OCT) in the evaluation of astrocytic hamartomas has been less well-documented. By spectral-domain OCT (SD-OCT), astrocytic hamartoma consists of a solid intraretinal mass continuous with the inner retina, often with hyperreflective (Source: Ophthalmic Surgery, La...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - September 14, 2017 Category: Opthalmology Authors: Stephen G. Schwartz, MD, MBA Source Type: research

En Face Optical Coherence Tomography Angiography Imaging Versus Fundus Photography in the Measurement of Choroidal Nevi
Choroidal nevi are the most common benign intraocular tumors, reported in large population studies to have anywhere between a 4% to 8% prevalence rate in the Caucasian population.1 –4 These tumors are commonly diagnosed as incidental findings on fundoscopic examination, as almost all nevi are asymptomatic.5 Lesions are classically well-defined, round or oval, flat, pigmented or nonpigmented tumors that can be located anywhere in the fundus. The cumulative incidence of transf ormation to choroidal melanoma is 0.78% by the age of 80 years.6–11Choroidal melanoma occurs in six to seven per 1 (Source: Ophthalmic Surgery, La...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - September 14, 2017 Category: Opthalmology Authors: Michele D. Lee, MD Source Type: research

Confluent Endpoint Subthreshold Argon Laser for Serous Macular Detachment in Tilted Disc Syndrome Refractory to Anti-VEGF
Tilted disc syndrome (TDS) is a relatively common congenital optic nerve anomaly that can be accompanied by macular complications such as choroidal neovascularization (CNV), polypoidal choroidal vasculopathy (PPCV), retinal pigment epithelium (RPE) changes and macular serous detachment.1,2The treatment of the macular serous detachment secondary to TDS is still controversial. There are reports describing the successful use of intravitreal anti-vascular endothelial growth factor (VEGF) injections of aflibercept (Eylea; Regeneron, Tarrytown, NY) and focal laser photocoagulation,3,4 whereas (Source: Ophthalmic Surgery, Lasers ...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - September 14, 2017 Category: Opthalmology Authors: Maria Fernanda Abalem, MD Source Type: research

Multicenter, Randomized Clinical Trial to Assess the Effectiveness of Intravitreal Injections of Bevacizumab, Triamcinolone, or Their Combination in the Treatment of Diabetic Macular Edema
Diabetic retinopathy (DR) affects more than 90 million people worldwide and it is the leading cause of vision loss and blindness in working-aged adults .1 The most prevalent cause of vision loss in non-proliferative DR is diabetic macular edema (DME).2The pathogenesis of DME is related to ischemia, oxidative stress, inflammation, and vascular dysfunction.3 –5 The upregulation of inflammatory factors, including vascular endothelial growth factor (VEGF), intracellular adhesion molecule-1, interleukin-6, and monocyte chemotactic protein-1, is responsible for leukostasis within the retinal (Source: Ophthalmic Surgery, Lasers...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - September 14, 2017 Category: Opthalmology Authors: Hermelino O. Neto, MD, PhD Source Type: research

Cataract Surgery in Patients With Wet Macular Degeneration
Howard F. Fine, Practical Retina Co-EditorCorrelation does not imply causation. Cataracts and macular degeneration are both common conditions and both are related to aging. Controversy has raged in the ophthalmic literature regarding any links between the two. Although some smaller studies suggested cataract surgery might increase the risk of conversion from dry to wet age-related macular degeneration (AMD), the AREDS 2 Study definitively concluded that cataract surgery does not increase this risk.Another logical question to address is whether cataract surgery can worsen wet AMD, due to (Source: Ophthalmic Surgery, Lasers ...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - September 14, 2017 Category: Opthalmology Authors: Michael D. Ober, MD Source Type: research

Multi-Modal Imaging Including Optical Coherence Tomography Angiography in Patients With Posterior Multifocal Placoid Pigment Epitheliopathy
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a white dot syndrome, hence being a primary inflammatory capillaropathy (PICCP). Due to the predominant involvement of the choriocapillaris, APMPPE is also called multifocal ischemic choroidopathy.1 The pathology is characterized by yellowish inflammatory lesions localized in the outer retina, the retinal pigment epithelium (RPE), and the choroid.2APMPPE is a rare inflammatory disease affecting the choriocapillaris and the avascular part of the retina (RPE and the outer layers of the retina).3,4 The main initial clinical (Source: Ophthalmic Surgery, Lase...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - September 14, 2017 Category: Opthalmology Authors: Jens Ulrich Werner, MD Source Type: research

High-Dose Decanted Triamcinolone for Treatment-Resistant Persistent Macular Edema
Macular edema (ME) is associated with a variety of retinal disorders and ocular inflammatory conditions including diabetes, retinal vein occlusion (RVO), and uveitis. Although anti-vascular endothelial growth factor (VEGF) intravitreal injections have generally become the initial treatment of choice for many forms of ME,1 intravitreal steroids still play a key role in the treatment paradigm, particularly in retinovascular disease.2,3 There is growing evidence suggesting that disease processes such as chronic diabetic macular edema (DME) may have an inflammatory component and, thus, may be (Source: Ophthalmic Surgery, Laser...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - September 14, 2017 Category: Opthalmology Authors: Ilkay Kilic Muftuoglu, MD Source Type: research

Centrifugal Extension of Retinal Atrophy in Retinal Pigment Epithelium Tears Secondary to Age-Related Macular Degeneration
A retinal pigment epithelium (RPE) tear develops when the RPE detaches from the Bruch's membrane and tears off. When the RPE retracts and its edges roll, the Bruch's membrane is left exposed in the part adjacent to the hyperpigmented area consisting of the retracted RPE. The area in which RPE is lost (and Bruch's membrane is exposed) is ultimately subject to chorioretinal atrophy, which results in the development of a scotoma.1,2An RPE tear typically occurs secondary to exudative age-related macular degeneration (AMD)3 as part of the clinical course of pigment epithelial detachment (PED) (Source: Ophthalmic Surgery, Lasers...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - September 14, 2017 Category: Opthalmology Authors: Vittorio Capuano, MD Source Type: research

Whither (or Wither) Adherence to Retina Trial Protocols in Clinical Practice?
Darius M. Moshfeghi, Editor in ChiefContinuous dosing treatment regimens with vascular growth factor inhibitors (VEGF-i) as evaluated by randomized controlled clinical trials for age-related macular degeneration, retinal vein occlusion, and diabetic macular edema offer superior visual acuity and anatomic outcomes compared to noncontinuous dosing regimens. Although, at first appearance, these differences seem to be marginal, they accrue over time, resulting in real loss of function that is significant. Similarly, arguments have been made that off-label use of repackaged bevacizumab (Avastin; (Source: Ophthalmic Surgery, Las...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - September 14, 2017 Category: Opthalmology Authors: Darius M. Moshfeghi, MD Source Type: research

Quantitative and Qualitative Features of Spectral-Domain Optical Coherence Tomography Provide Prognostic Indicators for Visual Acuity in Patients With Choroideremia
Choroideremia (CHM) (#MIM: 303100) is an X-linked chorioretinal dystrophy characterized by progressive atrophy of the choroid and outer retina. The estimated prevalence of affected males is one in 50,000 to 100,000.1,2 The CHM gene is located at Xq21.2 and encodes Rab escort protein 1 (REP-1).1,3 The majority of mutations in the CHM gene are loss of function,3,4 although two missense mutations L550P and H507R have been identified,5 but no genotype-phenotype correlation has been established.6,7The advent of emerging human gene therapy clinical trials calls for suitable imaging techniques for (Source: Ophthalmic Surgery, Las...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - September 14, 2017 Category: Opthalmology Authors: Alessandro Abbouda, MD Source Type: research

Vascular Density of Retinal Capillary Plexuses in Different Subtypes of Macular Hole
The understanding of vitreomacular interface disorders has been considerably fostered by the development of high-resolution spectral-domain optical coherence tomography (SD-OCT).1 Such advances in macular imaging have facilitated both the study and the classification of each different clinical entity.Although OCT-based diagnostic criteria for full-thickness macular hole (FTMH) and for non-FTMH have been fully described in literature, significant controversy still exists regarding their pathogenesis, management, and prognosis.1,2 Indeed, much morphological heterogeneity may be found while (Source: Ophthalmic Surgery, Lasers...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - August 16, 2017 Category: Opthalmology Authors: Luisa Pierro, MD Source Type: research

Evaluation of Macular Perfusion in Healthy Smokers by Using Optical Coherence Tomography Angiography
Acute and chronic effects of cigarette smoking on ocular circulation have been reported in the literature since the 1980s.1 –3 Although mechanisms responsible for sympathetic activation by cigarette smoking in humans have been shown, hemodynamic changes associated with smoking on ocular blood circulation is not yet fully known.4Ocular blood flow assessment techniques used in humans such as color duplex imaging, laser speckle flowgraphy, laser Doppler velocimetry, and flowmetry are well-documented and provide measurements of different segments of ocular blood flow.5 –11Recently, developments in (Source: Ophthalmic Surge...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - August 16, 2017 Category: Opthalmology Authors: Ziya Ayhan, MD Source Type: research

Swept-Source Optical Coherence Tomography Angiography in West Nile Virus Chorioretinitis and Associated Occlusive Retinal Vasculitis
West Nile virus (WNV) infection is a worldwide distributed arboviral disease that may cause severe neurologic disease, usually in association with advanced age and diabetes.1 –3 Bilateral multifocal chorioretinitis, with typical clinical and angiographic features of chorioretinal lesions and a self-limited disease course, has been recognized as the most common ocular manifestation of WNV infection.1–4 Retinal vascular involvement also has been described including ret inal hemorrhages, retinal vascular sheathing, retinal vascular leakage on fluorescein angiography (FA), and, rarely, occlusive (Source: Ophthalmic Surgery...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - August 16, 2017 Category: Opthalmology Authors: Moncef Khairallah, MD Source Type: research

The Role of Pneumatic Retinopexy: Lessons Learned and Keys to Successful Outcomes
Howard F. Fine, Practical Retina Co-EditorMost surgical subspecialties evolve to provide increasingly less-invasive approaches for patients. This trend often maximizes outcomes while minimizing patient recovery, surgical comorbidities, and cost. One of the common keys to success is appropriate patient selection.Similarly, ophthalmic surgery is increasingly moving away from hospitals and into ambulatory surgical centers (ASCs). Although there are often improvements in efficiency and turnover time, ASC's quite frequently are limited in staffing for emergency night and weekend cases. Thus, (Source: Ophthalmic Surgery, Lasers ...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - August 16, 2017 Category: Opthalmology Authors: Michael N. Cohen, MD Source Type: research

8 Questions with Darius Moshfeghi
Darius MoshfeghiMar ía H. BerrocalInterview with Mar ía H. Berrocal, MDDarius M. Moshfeghi, MD: Who has had the greatest influence on your career?Mar ía H. Berrocal, MD: My father, Stanley Chang, and Don Gass had the most influence on me as a retinal specialist. For my father, the first retinal specialist in Puerto Rico, ophthalmology was his life. He loved to work and teach, he went to every meeting, and his best friends were in the field. I ro unded with him, worked in his office in high school, and travelled to many meetings. From him I learned how priceless loving what you do can be, and the (Source: Ophthalmic Surg...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - August 16, 2017 Category: Opthalmology Authors: Mar ía H. Berrocal, MD Source Type: research