Operative Techniques in Orthopaedics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Biologics and Cell-Based Treatments for Upper Extremity Injuries
Many orthopaedic conditions of the upper extremity can have a protracted course of conservative management during which the patient gains may be unpredictable. More specifically, lateral epicondylitis, medial epicondylitis, and partial ulnar collateral ligament tears can be the cause of debilitating pain that may not have durable long-term relief without a surgical intervention. Recent advances have led to an expanded role of biologics in the treatment of orthopaedic conditions. Some of the developing modalities include blood-derived products, marrow-derived products, and stem cells. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - June 12, 2016 Category: Orthopaedics Authors: Stephenson Ikpe, Bryson Lesniak Source Type: research

Cell-Based Therapies for Degenerative Disc Diseases
Intervertebral discs degeneration are responsible for most of cases of low back pain, which affects millions of people worldwide. Current clinical therapies for degenerative disc diseases involve medications or physiotherapy for mild to moderate degeneration, and surgeries for severe degeneration. However, current treatments aim to remove symptoms sometimes at the cost of mobility instead of restoring the biological function. Future therapy for disc repair is in development by biological strategies, including protein or growth factor injections, gene therapy or cell therapy approaches. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - June 12, 2016 Category: Orthopaedics Authors: Feng-Juan Lv, Victor Y.L. Leung, Kenneth M.C. Cheung Source Type: research

Cell Mediated Pathologies in Traumatic Orthopaedic Injuries
Physical trauma is one of the most common mechanisms leading to Orthopaedic injury. The trauma and associated inflammatory response initiates the process of tissue regeneration and repair, which includes the recruitment and/or induction of multipotential cells to participate in the process. Too much inflammation can overwhelm this response to cause scarring. While stem cells have been extensively studied as therapy for regenerating functional tissues, concerns of ethics, availability, and ease of clinical utility call for investigation into an alternative source of multipotential cells for potential therapeutic use. (Sourc...
Source: Operative Techniques in Orthopaedics - June 12, 2016 Category: Orthopaedics Authors: Daniel W. Griffin, Youngmi Ji, Vyomesh Patel, Leon J. Nesti Source Type: research

Cell and Biologic-Based Treatment of Flexor Tendon Injuries
The 2 primary factors leading to poor clinical results after intrasynovial tendon repair are adhesion formation within the digital sheath and repair-site elongation and rupture. As the outcomes following modern tendon multistrand repair and controlled rehabilitation techniques are often unsatisfactory, alternative approaches, such as the application of growth factors and mesenchymal stem cells, have become increasingly attractive treatment options. Successful biological therapies require carefully controlled spatiotemporal delivery of cells, growth factors, and biocompatible scaffold matrices to simultaneously (1) promote ...
Source: Operative Techniques in Orthopaedics - June 12, 2016 Category: Orthopaedics Authors: Stephen W. Linderman, Richard H. Gelberman, Stavros Thomopoulos, Hua Shen Source Type: research

Cartilage Therapy & Repair in Equine Athletes
The status of articular cartilage often defines the level, progression and subsequent prognosis of joint disease in both human and equine athletes. While methods to diagnose equine cartilage defects have significantly improved over the last decade, articular cartilage damage and ensuing osteoarthritis (OA) remain a challenge to treat. Two categories of surgical options for cartilage repair in the horse are typically considered: palliative, reparative/restorative. Palliative surgical care consists of arthroscopic debridement and lavage, while reparative options involve the use of marrow stimulation techniques. (Source: Oper...
Source: Operative Techniques in Orthopaedics - June 12, 2016 Category: Orthopaedics Authors: Sherry A. Johnson, David D. Frisbie Source Type: research

Cell and Biomimetic Scaffold-Based Approaches for Cartilage Regeneration
This article discusses tissue engineering approaches in the repair of focal cartilage defects and degenerative joint conditions. It introduces the traditionally applied methods and provides a look at newer clinical and preclinical cell-based therapies for these treatments. In addition, cutting-edge approaches, both on the cellular front and the scaffold fabrication front, are examined for potential clinical application. Finally, the article closes with a look at future perspectives and directions in studying and understanding degenerative joint diseases. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - June 12, 2016 Category: Orthopaedics Authors: Aaron X. Sun, Piya-on Numpaisal, Riccardo Gottardi, He Shen, Guang Yang, Rocky S. Tuan Source Type: research

The Current State of Stem Cell Therapies in Sports Medicine
The theoretical clinical potential of stem cells in the orthopaedic sports medicine setting is unprecedented. The application of cellular-based treatments, such as stem cells represents a fascinating and continuously evolving therapeutic approach into treating underlying pathologies. In recent years, technological advancements and innovation have shifted the mindset of clinicians from treating symptomatology to fundamentally altering the underlying disease process at the primordial molecular level. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - June 12, 2016 Category: Orthopaedics Authors: Jeffrey M. DeLong, James P. Bradley Source Type: research

Cell and Biomimetic Scaffold Based Approaches for Cartilage Regeneration
This chapter discusses tissue engineering approaches in the repair of focal cartilage defects and degenerative joint conditions. It introduces the traditionally applied methods and provides a look at newer clinical and pre-clinical cell-based therapies for these treatments. In addition, cutting-edge approaches, both on the cellular front and the scaffold fabrication front, are examined for potential clinical application. Finally, the chapter closes with a look at future perspectives and directions in studying and understanding degenerative joint diseases. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - June 12, 2016 Category: Orthopaedics Authors: Aaron X Sun, Piya-on Numpaisal, Riccardo Gottardi, He Shen, Guang Yang, Rocky S Tuan Source Type: research

Sexual Dimorphism in Stem Cell based therapies for the Musculoskeletal System
Musculoskeletal health is one of the areas of medicine in which the differences between males and females are most striking. Differences in disease prevalence, pain sensation, drug handling, and healing responses between individuals have known biologic bases; however, how these biologic processes are affected by sex is unclear. In skeletal muscle tissues, stem cells and progenitor cells are known to persist throughout life and contribute to the ongoing process of repair and regeneration. However, currently, there is a paucity of literature that describes the sex-related differences in satellite cells and other muscle stem ...
Source: Operative Techniques in Orthopaedics - June 12, 2016 Category: Orthopaedics Authors: Jihee Sohn, Johnny Huard Source Type: research

Biologics and cell based treatments for upper extremity injuries
Many orthopaedic conditions of the upper extremity can have a protracted course of conservative management during which the patient gains may be unpredictable. More specifically, lateral epicondylitis, medial epicondylitis and partial ulnar collateral ligament tears can be the cause of debilitating pain that may not have durable long-term relief without a surgical intervention. Recent advances have led to an expanded role of biologics in the treatment of orthopaedic conditions. Some of the developing modalities include blood-derived products, marrow-derived products, and stem cells. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - June 12, 2016 Category: Orthopaedics Authors: Stephenson Ikpe, Bryson Lesniak Source Type: research

Cell-based Therapies for Degenerative Disc Diseases
Intervertebral discs (IVDs) degeneration are responsible for the majority of cases of low back pain, which affects millions of people worldwide. Current clinical therapies for degenerative disc diseases (DDD) involve medications or physiotherapy for mild to moderate degeneration, and surgeries for severe degeneration. However, current treatments aim to remove symptoms sometimes at the cost of mobility instead of restoring the biological function. Future therapy for disc repair is in development by biological strategies, including protein/growth factor injections, gene therapy or cell therapy approaches. (Source: Operative ...
Source: Operative Techniques in Orthopaedics - June 12, 2016 Category: Orthopaedics Authors: Feng-Juan Lv, Victor YL Leung, Kenneth MC Cheung Source Type: research

Cell and Biologic-Based Treatment of Flexor Tendon Injuries
The two primary factors leading to poor clinical results after intrasynovial tendon repair are adhesion formation within the digital sheath and repair-site elongation and rupture. As the outcomes following modern tendon multi-strand repair and controlled rehabilitation techniques are often unsatisfactory, alternative approaches, such as the application of growth factors and mesenchymal stem cells (MSCs), have become increasingly attractive treatment options. Successful biological therapies require carefully controlled spatiotemporal delivery of cells, growth factors, and biocompatible scaffold matrices in order to simultan...
Source: Operative Techniques in Orthopaedics - June 12, 2016 Category: Orthopaedics Authors: Stephen W. Linderman, Richard H. Gelberman, Stavros Thomopoulos, Hua Shen Source Type: research