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Application of Tendon Stem/Progenitor Cells and Platelet-Rich Plasma to Treat Tendon Injuries
Tendon injuries such as tendinopathy are a serious health care problem in the United States. However, current treatments of tendon injuries are largely palliative. Biological treatments, including tendon stem/progenitor cells (TSCs) and platelet-rich plasma (PRP) hold great potential to effectively treat tendon injuries. TSCs are tendon-specific stem cells and have the ability to differentiate into tenocytes, the resident tendon cells responsible for tendon homeostasis and tendon repair in case of an injury. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - March 3, 2016 Category: Orthopaedics Authors: James H-C. Wang, Xavier Nirmala Source Type: research

Biologic Treatments for Hip Disorders: A Focus On Platelet-Rich Plasma
The purpose of this systematic review was to assess the role of platelet-rich plasma (PRP) in the treatment of various hip conditions (e.g. avascular necrosis, osteoarthritis, femoroacetabular impingement, labral tears). The Medline, Embase, and PubMed databases were searched on August 5, 2015 for English-language studies that addressed PRP use in any hip condition. The studies were systematically screened by two reviewers and data abstracted in duplicate. There were 11 eligible studies (five randomized controlled trials, one prospective comparative study, two case series, and three case reports) reporting on 765 patients....
Source: Operative Techniques in Orthopaedics - March 3, 2016 Category: Orthopaedics Authors: Ivan Dzaja, Jeffrey Kay, Darren de, Nicole Simunovic, Olufemi R. Ayeni Source Type: research

Biologic Treatments for Hip Disorders: A Focus On Platelet-Rich Plasma
The purpose of this systematic article was to assess the role of platelet-rich plasma (PRP) in the treatment of various hip conditions (eg, avascular necrosis, osteoarthritis, femoroacetabular impingement, and labral tears). The Medline, Embase, and PubMed databases were searched on August 5, 2015 for English language studies that addressed PRP use in any hip condition. The studies were systematically screened by 2 reviewers and data abstracted in duplicate. There were 11 eligible studies (5 randomized controlled trials, 1 prospective comparative study, 2 case series, and 3 case reports) reporting on 765 patients. (Source:...
Source: Operative Techniques in Orthopaedics - March 2, 2016 Category: Orthopaedics Authors: Ivan Dzaja, Jeffrey Kay, Darren de SA, Nicole Simunovic, Olufemi R. Ayeni Source Type: research

Overview on Small Molecule Biologic and Gene-Based Treatments in Sports Medicine
The use of biologic treatment strategies in the nonoperative and operative care of orthopaedic and sports injuries continues to expand in parallel with our understanding of the healing response after injuries. This is in large part due to the growing number of basic, translational, and clinical studies investigating the use of biologic augmentation in musculoskeletal care. Platelet-rich plasma, growth factors, and cell- and gene-based treatments are among the most commonly explored options, and they have found varying levels of success in promoting soft tissue and osseous healing. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - March 2, 2016 Category: Orthopaedics Authors: Alexander E. Weber, Ryan A. Mlynarek, Brian J. Cole, Asheesh Bedi Source Type: research

Small Molecule Biologic and Gene Based Treatments in Sports Medicine
There is a timely need for “cures” of musculoskeletal diseases, such as osteoarthritis, that result from sports injuries. The debilitating nature of osteoarthritis is displayed in joint pain and stiffness, slowly leading to joint dysfunction and eventually affecting the overall health of the patient by limiting activities of daily living. However, despite potential secondary development of osteoarthritis, injured athletes actively seek accelerated return to sport. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - March 2, 2016 Category: Orthopaedics Authors: Volker Musahl, Rocky Tuan Source Type: research

Platelet-Rich Plasma in Treating Patellar Tendinopathy
Patellar tendinopathy is a common source of pain and dysfunction in both high demand and recreational athletes. It can be a difficult condition to treat and uniform consensus on the optimal treatment strategy is currently lacking. Accordingly, platelet-rich plasma (PRP) has emerged as a treatment option for tendinosis that may improve the healing process and speed recovery. It is becoming increasingly evident that PRP is comprised of a cocktail of growth factors and cellular components that synergize to contribute to its established anabolic effects. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - March 2, 2016 Category: Orthopaedics Authors: Guang-Ting Cong, Camila Carballo, Christopher L. Camp, Zoe Album, Amir Lebaschi, Jianchun Zong, Scott A. Rodeo Source Type: research

Small Molecules Alone or in Combination to Treat Joint Disease and Progress Towards Gene Therapy
The field of biologics for joint disease, specifically cartilage injury and osteoarthritis, is one that has stimulated much excitement in the area of orthopedics. The deficit of growth factors and anti-catabolics in joint disease is now a well-recognized problem however, unraveling the mystery associated with appropriate dose and timing of administration and when these molecules might have their most therapeutic benefits -will be the subject of study for decades to come. Further, the technique of how these proteins are enhanced in the joint to result in the greatest impact remains in question. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - March 2, 2016 Category: Orthopaedics Authors: Laurie R. Goodrich, C. Wayne McIlwraith Source Type: research

“Current State for Clinical use of Stem Cells and PRP”
In the management of common orthopaedic pathology involving tendons, ligaments, bone and articular cartilage, the application of small molecules and biologic compounds has expanded greatly in the past decade. In particular, the use of platelet-rich plasma (PRP) and stem cells has gained significant attention for potential therapeutic augmentation of healing, modulation of inflammatory cascades and pain modulation. Despite the increase in clinical application and interest, there has been a paucity of high-level of evidence studies supporting the use of these biologic agents. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - March 2, 2016 Category: Orthopaedics Authors: Jason P. Zlotnicki, Jonathan Watson, Ben B. Rothrauff, Carola F. Van Eck, Volker Musahl Source Type: research

Management of Athletic Turf Toe using Biologics
Turf toe is a common injury in a variety of different athletes, especially those involved in contact sports played on rigid surfaces. It is caused by a hyperextension injury to the hallux metatarsophalangeal (MTP) joint resulting in attenuation or tearing of the plantar capsular ligamentous complex. Treatment generally consists of non-operative measures such as rest, ice, non-steroidal anti-inflammatory drugs (NSAIDS), taping, a stiff-sole shoe, walking boot or casting. There has been a recent increase in the use of biologics, such as platelet rich plasma (PRP) and autologous conditioned plasma (ACP) for the treatment of a...
Source: Operative Techniques in Orthopaedics - March 2, 2016 Category: Orthopaedics Authors: Aaron V. Mares, Ryan Schreiter, Carola F. van Eck, Robert Blanc, Volker Musahl Source Type: research

Overview on Small Molecule Biologic and Gene-Based Treatments in Sports Medicine
The use of biologic treatment strategies in the nonoperative and operative care of orthopaedic and sports injuries continues to expand in parallel with our understanding of the healing response after injuries. This is in large part because of the growing number of basic, translational, and clinical studies investigating the use of biologic augmentation in musculoskeletal care. Platelet-rich plasma, growth factors, and cell-based and gene-based treatments are among the most commonly explored options, and they have found varying levels of success in promoting soft tissue and osseous healing. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - March 1, 2016 Category: Orthopaedics Authors: Alexander E. Weber, Ryan A. Mlynarek, Brian J. Cole, Asheesh Bedi Source Type: research

Small Molecule Biologic and Gene Based Treatments in Sports Medicine
There is a timely need for “cures” of musculoskeletal diseases, such as osteoarthritis, that result from sports injuries. The debilitating nature of osteoarthritis is displayed in joint pain and stiffness, slowly leading to joint dysfunction and eventually affecting the overall health of the patient by limiting activities of daily living. However, despite potential secondary development of osteoarthritis, injured athletes actively seek accelerated return to sport. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - March 1, 2016 Category: Orthopaedics Authors: Volker Musahl, Rocky Tuan Source Type: research

Platelet-Rich Plasma in Treating Patellar Tendinopathy
Patellar tendinopathy (PT) is a common source of pain and dysfunction in both high-demand and recreational athletes. It can be a difficult condition to treat, and uniform consensus on the optimal treatment strategy is currently lacking. Accordingly, platelet-rich plasma (PRP) has emerged as a treatment option for tendinosis that may improve the healing process and speed recovery. It is becoming increasingly evident that PRP comprises a cocktail of growth factors and cellular components that synergize to contribute to its established anabolic effects. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - March 1, 2016 Category: Orthopaedics Authors: Guang-Ting Cong, Camila Carballo, Christopher L. Camp, Zoe Album, Amir Lebaschi, Jianchun Zong, Scott A. Rodeo Source Type: research

Small Molecules Alone or in Combination to Treat Joint Disease and Progress Toward Gene Therapy
The field of biologics for joint disease, specifically articular cartilage injury and osteoarthritis, is one that has stimulated much excitement in the area of orthopaedics. The deficit of growth factors and anticatabolics in joint disease is now a well-recognized problem; however, unraveling the mystery associated with appropriate dose and timing of administration and when these molecules might have their most therapeutic benefits would be the subject of study for decades to come. Further, the technique of how these proteins are enhanced in the joint to result in the greatest influence remains in question. (Source: Operat...
Source: Operative Techniques in Orthopaedics - March 1, 2016 Category: Orthopaedics Authors: Laurie R. Goodrich, C. Wayne McIlwraith Source Type: research

Current State for Clinical Use of Stem Cells and Platelet-Rich Plasma
In the management of common orthopaedic pathology involving tendons, ligaments, bone, and articular cartilage, the application of small molecules and biologic compounds has expanded greatly in the past decade. In particular, the use of platelet-rich plasma (PRP) and stem cells has gained significant attention for potential therapeutic augmentation of healing, modulation of inflammatory cascades, and pain modulation. Despite the increase in clinical application and interest, there has been a paucity of high level of evidence studies supporting the use of these biologic agents. (Source: Operative Techniques in Orthopaedics)
Source: Operative Techniques in Orthopaedics - March 1, 2016 Category: Orthopaedics Authors: Jason P. Zlotnicki, Jonathan Watson, Ben B. Rothrauff, Carola F. Van Eck, Volker Musahl Source Type: research