Rthp-08. long-term follow up of high-risk low-grade glioma patients treated with radiotherapy (rt) or rt and adjuvant temozolamide or procarbazine, ccnu, and vincristine (pcv) chemotherapy at a single institution
CONCLUSION:Similar to RTOG-9802, chemotherapy improved survival compared to RT in our small, retrospective study. TMZ was associated with improved survival in astrocytomas compared to RT alone. Though not statistically significant, PCV was associated with improved OS compared to TMZ, however, a higher proportion of oligodendroglioma patients received PCV. Molecular markers were not routinely assessed in this cohort during this era. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Kreofsky, C., Youland, R., Buckner, J., Uhm, J., Lachance, D., Laack, N. Tags: RADIATION THERAPY Source Type: research
Rthp-07. impact of radiotherapy and gross-total resection for ependymoma in young children: a population-based study
Recent genomic characterization of pediatric ependymomas revealed a unique balanced genetic profile without recurrent mutations, predominantly associated with children under 3 years of age. We analyzed the prognostic factors and treatment outcomes of 493 patients between ages 0 and 3 with diagnosis of ependymoma identified from the Surveillance, Epidemiology, and End Results registry (1973-2013). The impact of treatment on overall survival (OS) was assessed by Log-rank test and multivariate Cox proportional hazard modeling. Radiation therapy (RT) was delivered to 51.9% of patients, and gross-total resection (GTR) was ...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Snider, C., Yang, K., Mack, S., Suh, J., Chao, S., Murphy, E. Tags: RADIATION THERAPY Source Type: research
Rthp-06. treatment of vestibular schwannoma with stereotactic radiation: a single institution comparison of 3 different linac-based fractionation schemas
CONCLUSIONS:All three regimens (cfSRT, hSRT, and SRS) demonstrated similar excellent local control with minimal toxicity. However, the ability of hSRT to treat larger tumors (or tumors abutting the brain stem) with comparable outcomes to SRS and the greater patient convenience when compared to cfSRT, suggest that hSRT may be an optimal treatment approach. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Goyal, U., Slane, B., Grow, J., Morrison, C., Hullet, C., Georgiev, G., Sanan, A., Stea, B. Tags: RADIATION THERAPY Source Type: research
Rthp-05. intraoperative radiotherapy (iort) using low-energy x-rays in a cohort of predominantly incompletely resected newly diagnosed glioblastoma multiforme (intrago trial)
CONCLUSIONS:IORT with low-energy photons in addition to standard therapy is safe and tolerable. Despite multiple poor prognostic factors, median and local PFS compare favourably to historic data (mPFS was 6.9 m in the EORTC/NCIC trial). The technique is now tested in a multinational randomized phase III trial (NCT02685605). (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Giordano, F. A., Brehmer, S., Mürle, B., Welzel, G., Sperk, E., Keller, A., Abo-Madyan, Y., Clausen, S., Schneider, F., Herskind, C., Seiz-Rosenhagen, M., Groden, C., Schmiedek, P., Glas, M., Hänggi, D., Petrecca, K., Wenz, F. Tags: RADIATION THERAPY Source Type: research
Rthp-04. reirradiation for diffuse intrinsic pontine glioma: a single-institution experience
CONCLUSIONS:Our experience demonstrates the feasibility of reirradiation for recurrent DIPG and illustrates its potential efficacy in symptom management and prolongation of life, which may be furthered with the addition of concomitant PD-1 inhibition. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Duriseti, S., Kline-Nunnally, C., Banerjee, A., Nicolaides, T., Raber, S., Gupta, N., Haas-Kogan, D., Braunstein, S., Mueller, S. Tags: RADIATION THERAPY Source Type: research
RTHP-03. GENE EXPRESSION LANDSCAPE INCLUDING miRNAs IN DELAYED RADIATION NECROSIS OF BRAIN
CONCLUSIONS:This DBRN model would be useful for understanding the pathophysiological mechanisms and for searching therapeutic molecular targets or diagnostic biomarkers. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Miyatake, S.-I., Toho, T., Fujita, M., Furuse, M., Kawabata, S., Kuroiwa, T., Nonoguchi, N. Tags: RADIATION THERAPY Source Type: research
Rthp-02. towards therapeutic optimism - increasing radiation therapy utilization in patients with glioblastoma
CONCLUSIONS:The rate of RT utilization is increasing, in contrast to a previous trend of declining use. In the absence of significant new data for RT, this change is likely due to a shift toward greater therapeutic optimism in light of other advances in the field. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Johnson, D., Kaufmann, T., Ashman, J., Porter, A. Tags: RADIATION THERAPY Source Type: research
Rthp-01. comparison of co-planar and non-coplanar treatment planning for tumor nearby critical organs in high grade gliomas
CONCLUSION:IMRT techniques provided better target coverage than VMAT plans. VMAT techniques reduced treatment delivery time compared to IMRT techniques. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Ba, H., Ayata, s., Ceylan, C. Tags: RADIATION THERAPY Source Type: research
RBIO-06. CROSSTALK OF ErbB2 WITH LEF1 REGULATES JAGGED1-MEDIATED RADIORESISTANCE IN GLIOBLASTOMA
ErbB2 (Her2) belongs to the family of EGF receptor tyrosine kinases and plays a vital oncogenic role in several cancers. Gliomas are reported to have aberrant overexpression of ErbB2, but its role in glioma biology and treatment resistance have not been well studied. We have previously reported that ionizing radiation (IR) increases cell invasiveness and radioresistance. In our preliminary studies, we observed that shRNA mediated ErbB2 silencing in glioma cell lines resulted in a significant inhibition of proliferation and invasion which was associated with a suppression of Notch signaling. To examine its role in radioresi...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Kesanakurti, D., Xu, J., Kaur, B., Puduvalli, V., Canella, A. Tags: RADIOBIOLOGY Source Type: research
RBIO-05. miRNAs THAT CONFER GLIOBLASTOMA RESISTANCE: IS THE COMBINATION MERELY A SUM OF THE PARTS?
CONCLUSION:Through an unbiased, systematic screen designed to identify miR combinations that confer glioblastoma radiation resistance, we uncovered a novel miRNA combination. The effects of the four miRNAs in aggregate was distinct from that seen with each individual siRNAs. The study points to the importance of an integrated study of miRNA combinations relative to the characterization of each individual miRNAs. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Chen, C., Moskwal, P., Zinn, P., Eun Choi, Y., Shukla, S., Fendler, W., Lu, J., Golub, T., Hjelmeland, A., Chowdhury, D. Tags: RADIOBIOLOGY Source Type: research
Rbio-04. fractal structure in the volumetric contrast enhancement of malignant gliomas as a marker of oxidative metabolic pathway gene expression
CONCLUSION:There is fractal structure in the volumetric enhancement pattern of glioblastomas, with dimension approximately 2.15. Variation in this fractal dimension, and therefore the complexity of contrast enhancement it reflects, is specifically associated with genetic correlates of a shift to glycolytic metabolism in tumor cells. Drugs that shift glioblastoma to oxidative metabolism have recently been identified as independent therapeutic agents as well as sensitizing agents for irradiation. Therefore, a radiogenomic marker of glucose metabolism, such as this fractal structure in enhancement, might help to guide individ...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Miller, K., Berendsen, S., Seute, T., Yeom, K., Gephardt, M., Grant, G., Robe, P. Tags: RADIOBIOLOGY Source Type: research
Rbio-03. improving gemcitabine-mediated radio-sensitization using molecularly targeted meningioma therapy
BACKGROUND:Of the many treatment options, gemcitabine has been currently used clinically to a variety of solid tumors types both as a chemotherapeutic agent and as a radiation sensitizer. However, it has been speculated that the gemcitabine plus relatively high dose of radiation increased the toxicity. Therefore, our current approaches to integrate of molecularly targeted agents, which potentially produce less toxicity than standard chemotherapy, and with gemcitabine-radiation improve chemo-radiation sensitivity.METHODS:We combined HDACs or Chk1 inhibitors with gemcitabine and radiation using three meningioma cell lines (B...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Das, A., McDonald, D. G., Alexander Vandergrift, W., Varma, A. K., Lindhorst, S. M., Raizer, J., Giglio, P., Patel, S. J., Decandio, M. L., Banik, N. L., Vanek, K. N., Jenrette, J. M., Cachia, D. Tags: RADIOBIOLOGY Source Type: research
RBIO-02. PERSONALIZED SCREENING OF RADIOSENSITIZATION BY A TGF-{beta} SMALL MOLECULE INHIBITOR USING CULTURED EXPLANTS OF HIGH GRADE GLIOMA (HGG) PATIENT SPECIMENS
High-grade gliomas (HGG) manifest profound radioresistance via cell-intrinsic and microenvironmental mechanisms. Transforming growth factor-β (TGF-β) is a key component of the HGG microenvironment, which we have shown enables radioresistance directly by enforcing an effective DNA damage response (DDR), and indirectly by promoting glioma stem cell self-renewal. Heterogeneity of HGG subtypes and patient differences raise the question of general utility of TGF-β inhibition for radiosensitization. Given the impact of microenvironment, we reasoned that personalized radiation biology could be attained by maintaini...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Ma, L., Sumru Bayin, N., Placantonakis, D., Helen Barcellos-Hoff, M. Tags: RADIOBIOLOGY Source Type: research
RBIO-01. RADIATION RESPONSES OF 2D AND 3D GLIOBLASTOMA CELLS: A NOVEL, 3D-SPECIFIC RADIOPROTECTIVE ROLE OF VEGF/Akt SIGNALING THROUGH FUNCTIONAL ACTIVATION OF NHEJ
Glioblastoma (GBM) is resistant to conventional treatments with dismal prognosis. . Tumours exhibit inherent resistance to radiation and chemotherapy which has been attributed to a subpopulation of cancer cells termed ‘GBM stem-like cells’ (GSC) characterised by multipotentiality and potent tumorigenic capacity. Anti-VEGF antibody bevacizumab increases progression-free survival of GBM patients in combination with standard radio-chemotherapy. We have previously shown that bevacizumab enhanced radiosensitivity of 3D GSC cultures in clonogenic and neurosphere formation assays, but had no effect on radiation respon...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Gomez-Roman, N. Tags: RADIOBIOLOGY Source Type: research
Rare-65. dysembryoplastic neuroepithelial tumors: 13 cases of a rare condition
CONCLUSIONS:This case series highlights key clinical themes in DNET cases as well as clinical areas of uncertainty. As previously reported, the most common presenting symptom was seizure, and the most common radiographic appearance was T1 non-enhancing, T2 hyperintense. Most tumors were located in the temporal lobe, and 12/13 patients were treated with gross total resection. Only one patient required repeat surgery for recurrence. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Goslinga, J., Gill, C., Batchelor, T. Tags: RARE TUMORS Source Type: research
