Surg-25. stability of shunt programmable valve settings with simultaneous use of the optune transducer array
In this study, shunt valve settings were stable over a period of five days despite concurrent Optune therapy. This is reassuring for patients with GBM that require simultaneous treatment with both the Optune device and a programmable shunt system. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Chan, A., Birk, H. Tags: SURGICAL THERAPY Source Type: research
Surg-24. surgical resection of fourth ventricular ependymomas - case series and technical nuances
CONCLUSIONS:Tumor adherence to the 4thventricular floor is not an absolute contraindication for complete resection. Intraoperative neuro-monitoring is essential, and the development of sustained, but not transient CN activity, and/or hemodynamically significant bradycardia should limit the extent of resection. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Winkler, E., Birk, H., Safaee, M., Yue, J., Burke, J., Viner, J., Pekmezci, M., Perry, A., Aghi, M., Berger, M. S., McDermott, M. Tags: SURGICAL THERAPY Source Type: research
Surg-23. patient experience and satisfaction with dexmedetomidine in awake craniotomy for brain tumours
CONCLUSIONS:The outcome of our survey looking at the use of dexmedetomidine +/- remifentanil matches the previous study in our institution using remifentanil+/-propofol and appears to be as equally as tolerated by patients. The use of dexmedetomidine has the added benefit of little or no respiratory depression. Larger studies are required to explore the true potential of dexmedetomidine further. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Roach, J., Weidmann, C., Chapman, R., Apostolopoulos, V., Wykes, V., Grundy, P. Tags: SURGICAL THERAPY Source Type: research
Surg-22. adult neurosurgical oncology at a large academic quaternary referral center: impact of residency training and volume on outcome
CONCLUSIONS:Morbidity and mortality rates are low and compare favorably to other published series. These data suggest that excellent outcomes for adult cranial tumor can be maintained in high volume clinical practices without sacrificing commitment to resident education. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Brown, D., Himes, B. Tags: SURGICAL THERAPY Source Type: research
Surg-21. case-matched study of effect of intra-operative mri on extent of resection and clinical outcome in glioma patients undergoing surgical resection
Recent studies indicate that increased extent of resection of malignant gliomas correlates with extended survival. Intra-operative MRI (iMRI) has been purported as a tool to aid surgeons in increasing the extent of resection. While several institutions have adopted iMRI, no reports to our knowledge discuss the effects of discontinuing its use. From July 2004 to June 2008, our institution used an intra-operative 1.5T MRI scanner (iMRI) to aid in glioma resection surgery. However, when the institution moved physically into a new hospital, the iMRI unit was discontinued. Using a single surgeon retrospective database, we ident...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Everson, R., Tucker, A., Garrett, M., Marcus, L., Harris, R., Prins, R., Ellingson, B., Liau, L. Tags: SURGICAL THERAPY Source Type: research
Surg-20. first in-human study of a novel device for convection enhanced delivery of topotecan and gadolinium for recurrent gbm: interim results
CONCLUSIONS:This first-in-human experience shows that the CMC provides high volume, backflow resistant CED and demonstrates the value associated with use of a tracer to image infusate distribution. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Vogelbaum, M., Ahluwalia, M., Peereboom, D., Stevens, G., Mohammadi, A., Brewer, C. Tags: SURGICAL THERAPY Source Type: research
Surg-19. day-case image-guided biopsy for brain tumours: a decade of experience
DISCUSSION:DIB surgery with close clinical and radiological surveillance is well-tolerated, safe and feasible. We advocate this concept is more widely adopted. REFERENCES: 1) Grundy P.L et al (2008) Br.J.Neurosurg (22) 360-367. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Wykes, V., McElligott, S., Duffill, J., Grundy, P. Tags: SURGICAL THERAPY Source Type: research
Surg-18. real-time intraoperative molecular diagnosis and surgical guidance using laser spectroscopy
CONCLUSIONS:Raman spectroscopy represents a new modality for in-vivo tissue characterisation with high accuracy. Our study demonstrates it can correctly characterise a range of different types of brain tumors rapidly during surgery. Current challenges to more widespread adoption include the modifications necessary for it to work in the OR and patient-patient and machine-machine variability. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Vaqas, B., ONeill, K., Short, M., Zeng, H., Patel, I., Faiz, U. Tags: SURGICAL THERAPY Source Type: research
Surg-17. gross total resection outcomes in adult patients with brainstem glioma
Brainstem glioma (BSG) is much more rare and heterogeneous in adults compared to pediatric population. Clinical outcome of this type of brain tumor remains poor despite aggressive treatment. We analyzed 1667 patients of age 19 or older with the diagnosis of BSG identified from the NCI Surveillance, Epidemiology, and End Results database (1973-2012). Surgical treatment was categorized into no surgery, subtotal resection (STR), and gross total resection (GTR). Kaplan-Meier analysis and multivariate Cox proportional hazard modeling were used to assess the impact of treatment on overall survival (OS). 54.6% were males, and 83....
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Yang, K., Kim, L., Suh, J., Murphy, E., Chao, S. Tags: SURGICAL THERAPY Source Type: research
Surg-16. magnetic resonance-guided laser ablation for the treatment of recurrent dural based tumors
CONCLUSIONS:MR-LITT is a promising technology for dural based tumor treatment. This initial study demonstrates that MR-LITT is safe and offers several advantages over open surgical treatment. Randomized studies are needed to evaluate its role as a treatment adjunct. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Ivan, M. E., Diaz, R. J., Berger, M., Osiason, D., Plate, T., Wallo, A., Komotar, R. J. Tags: SURGICAL THERAPY Source Type: research
Surg-15. integrating molecular markers and extent of resection for risk stratification of patients with newly-diagnosed glioblastoma: a multicentre study
CONCLUSION:The combination of MGMT-M and EoR ≥ 95% is synergistic in improving patient survival, possibly reflecting the improved efficacy of chemotherapy at lower residual tumour volumes. Review of remaining cases and recursive partitioning analysis(RPA) are pending, and will allow development of an integrative risk stratification algorithm. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Sayeed, W., Batuyong, E., Li, H., Cadieux, M., Kelly, J., Scott, J., Semenchuk, J., Pitz, M., Easaw, J. Tags: SURGICAL THERAPY Source Type: research
Surg-14. operative mortality rates of acoustic neuroma surgery: a nationwide cancer database analysis
CONCLUSIONS:The 30-day mortality rate following surgery for AN is 1/200 (0.5%), which is equivalent to the established in-hospital operative mortality rate, and is 2.5 times higher than the cumulative assessment from single-center studies (Sughrue et al., 2011). No patient demographic other than increasing medical comorbidities reached significance in predicting 30-day operative mortality. The nearly identical rates of 30-day and in-hospital mortality from separate nationwide analyses indicate that nearly all of the operative mortality occurs prior to initial postoperative discharge from the hospital. This mortality r...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: McClelland, S., Murphy, J. D., Thomas, C. R. Tags: SURGICAL THERAPY Source Type: research
Surg-12. laser interstitial thermal therapy (litt) to manage progressed glioblastoma during pregnancy
Glioblastoma (GB) is the most lethal primary brain tumor in adults. Despite optimized multimodality treatment, median overall survival is 14-16 months. While these tumors inevitably progress, the rare concurrence with pregnancy has been demonstrated to increase aggressive tumor behavior through mechanisms that have not been clearly defined. Pregnancy further complicates the already limited available treatment options for recurrent GB (rGB) due to pregnancy-associated host immunosuppression, increased metabolic and vascular demands, and the need to avoid risks to the fetus. Here, we review the literature of reported ne...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Gatson, N. T., Pillainayagam, C., Rao, G., Chi, T. L., Prabhu, S., Weathers, S.-P. Tags: SURGICAL THERAPY Source Type: research
Surg-11. personal preferences for gross total resection of glioblastoma: a pilot study
CONCLUSIONS:A physician’s choice survey suggests that preference for GTR of glioblastoma is influenced by tumor location and the values of the afflicted patient. These factors should be considered during patient counseling and surgical planning. *The findings of this study reflect only the opinions of the physicians surveyed and in no way reflect an official endorsement by the Society for Neuro-Oncology. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Wilson, B., Hirshman, B., Chen, C. Tags: SURGICAL THERAPY Source Type: research
Surg-10. impact of insurance status and race on receipt of surgery for acoustic neuroma: a national cancer database analysis
CONCLUSIONS:Elderly age, African-American race (by 30%), Medicare insurance (by 40%) and treatment at a community hospital (by 60%) were independent predictors for reduced receipt of AN surgery. Conversely, Medicaid insurance (by 20%), Charlson/Deyo score of one, central United States location, and treatment at an integrated network (by 20%) independently predicted increased receipt of AN surgery. Given that the adjusted relative risk for in-hospital mortality of AN surgery for African-Americans is 10.6 compared with Caucasians (Curry et al., 2009), and that private insurance reduces in-hospital and perioperative morb...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: McClelland, S., Murphy, J. D., Thomas, C. R. Tags: SURGICAL THERAPY Source Type: research
