Surg-12. laser interstitial thermal therapy (litt) to manage progressed glioblastoma during pregnancy

Glioblastoma (GB) is the most lethal primary brain tumor in adults. Despite optimized multimodality treatment, median overall survival is 14-16 months. While these tumors inevitably progress, the rare concurrence with pregnancy has been demonstrated to increase aggressive tumor behavior through mechanisms that have not been clearly defined. Pregnancy further complicates the already limited available treatment options for recurrent GB (rGB) due to pregnancy-associated host immunosuppression, increased metabolic and vascular demands, and the need to avoid risks to the fetus. Here, we review the literature of reported neurosurgical interventions for rGB during pregnancy, and are first to report a clinical case using laser interstitial thermal therapy (LITT) to manage GB recurrence during pregnancy. This work discusses the unique challenges related to determining the neurosurgical approach, selecting medical treatment, arranging multidisciplinary clinical follow-up, and evaluating neuroimaging pre- and post-LITT procedure. Ultimately, this research offers potential indications and considerations for use of the LITT neurosurgical approach in pregnant patients with progressed disease.
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: SURGICAL THERAPY Source Type: research