Rthp-07. impact of radiotherapy and gross-total resection for ependymoma in young children: a population-based study

Recent genomic characterization of pediatric ependymomas revealed a unique balanced genetic profile without recurrent mutations, predominantly associated with children under 3 years of age. We analyzed the prognostic factors and treatment outcomes of 493 patients between ages 0 and 3 with diagnosis of ependymoma identified from the Surveillance, Epidemiology, and End Results registry (1973-2013). The impact of treatment on overall survival (OS) was assessed by Log-rank test and multivariate Cox proportional hazard modeling. Radiation therapy (RT) was delivered to 51.9% of patients, and gross-total resection (GTR) was performed in 51.0% of patients. Tumor histology was WHO grade II (9391 ependymoma) in 62.1% of patients and grade III (9392 anaplastic ependymoma) in 37.9% of patients. OS at 10 years was 48.6% with median follow up 8.4 years. WHO grade was not predictive of OS, with 47.2% and 51.4% survival at 10 years for grade II and III (p=0.340), respectively. Extent of resection was significant to survival, as the OS at 10 years with GTR was 61.0%, while OS for patients with STR and biopsy was 38.7% and 35.2%, respectively (p<0.001). RT significantly benefitted OS for both grade II and III. 10 year OS for grade II was 50.8% with RT and 43.4% without RT (p=0.024); 10 year OS for grade III was 66.8% with RT and 35.5% without RT (p=0.001). Multivariate analysis showed significantly improved OS with RT (HR 0.566, 95% CI 0.412-0.777, p<0....
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: RADIATION THERAPY Source Type: research