Theoretical basis for a new approach of studying Emery-Dreifuss muscular dystrophy by means of thermography
Emery-Dreifuss muscular dystrophy (EDMD) is a clinical condition characterized by neuro-skeletal and cardiac impairments. By means of thermography, an image acquisition technique that allows the recording of the heat emitted by objects or bodies, news insight can be obtained insights about the evaluation and follow-up of this disease. Actually, musculoskeletal disorders are a major cause of counseling and access to rehabilitation services and are some of the most important problems that affect the quality of life of many people. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 2, 2018 Category: Biomedical Science Authors: A. Cabizosu, N. Carboni, A. Martinez-Almagro Andreo, J.M. Vegara-Meseguer, N. Marziliano, G. Gea Carrasco, G. Casu Source Type: research
Intracranial pressure and glaucoma: is there a new therapeutic perspective on the horizon?
Primary open-angle glaucoma is one of the leading causes of irreversible blindness worldwide. Raised intraocular pressure is the most important modifiable risk factor and lowering it remains the mainstay therapeutic approach for slowing optic nerve damage and visual field progression in glaucoma patients. An intriguing finding of clinical retrospective and prospective studies is that intracranial pressure is lower in patients with glaucoma. Furthermore, in a recent study on monkeys subjected to an implantation of a lumboperitoneal cerebrospinal fluid shunt to lower intracranial pressure, chronic reduction in intracranial p...
Source: Medical Hypotheses - July 2, 2018 Category: Biomedical Science Authors: Peter Wostyn, Debby Van Dam, Peter Paul De Deyn Source Type: research
No significant cancer mortality increase after the TMI accident
Sir, (Source: Medical Hypotheses)
Source: Medical Hypotheses - June 26, 2018 Category: Biomedical Science Authors: Alfred K örblein Source Type: research
Hypothesis Kynurenic and quinolinic acids: the main players of the kynurenine pathway and opponents in inflammatory disease
I hypothesize that the intermediates of the kynurenine (Kyn) pathway (KP) of tryptophan degradation kynurenic acid (KA) and quinolinic acid (QA) play opposite roles in inflammatory diseases, with KA being antiinflammatory and QA being immunosuppressant. Darlington et al. have demonstrated a decrease in the ratio of plasma 3-hydroxyanthranilic acid to anthranilic acid ([3-HAA]/[AA]) in many inflammatory conditions and proposed that this decrease either reflects inflammatory disease or is an antiinflammatory response. (Source: Medical Hypotheses)
Source: Medical Hypotheses - June 21, 2018 Category: Biomedical Science Authors: Abdulla A-B Badawy Source Type: research
Relapse Prevention: Using Sound to Reduce the Probability of Recidivism and Suffering Following Detoxification
The truth of the adage, “An ounce of prevention is worth a pound of cure”, is exemplified by the opioid crisis now facing the world. While the best way to rid society of drug addiction is to prevent it from occurring in the first place, this is highly unlikely in the near future given the many ways that individuals can be first exposed to some potentially addicting substance. When an addiction is established, the first treatment for it is detoxification, but the insidious nature of addiction is its propensity to relapse. (Source: Medical Hypotheses)
Source: Medical Hypotheses - June 20, 2018 Category: Biomedical Science Authors: Robert Sewak, Neil I. Spielholz Source Type: research
Several effects of boron are induced by uncoupling steroid hormones from their transporters in blood
Boron is increasingly added to food supplements due to multiple effects that have been reported in mammals after boric acid administration. Among these effects are inflammatory process control, bone and muscle strength enhancement, protein expression regulation, and a decreased risk of developing some pathologies in which these processes are key, such as osteoporosis, dermatological inflammatory non-infectious maladies and diseases affecting the central nervous system. Experimental data have suggested that steroid hormone levels in plasma change after boric acid administration, but a clear mechanism behind these variations...
Source: Medical Hypotheses - June 20, 2018 Category: Biomedical Science Authors: Martiniano Bello, Concepci ón Guadarrama-García, Luz M. Velasco-Silveyra, Eunice D. Farfán-García, Marvin A. Soriano-Ursúa Source Type: research
Should all women with postpartum depression be screened for bipolar disorder?
The term postpartum depression is used generically to denote occurrence of a depressive episode after childbirth. Emerging research suggests that bipolar disorder is common among women with postpartum depression. Due to the lack of awareness of its existence, bipolar postpartum depression is often misdiagnosed as major depressive disorder, causing long delays for women to receive appropriate treatment. We hypothesize that screening all women with postpartum depression for bipolar disorder would help correctly identify subgroups of women based on the underlying psychiatric diagnosis. (Source: Medical Hypotheses)
Source: Medical Hypotheses - June 19, 2018 Category: Biomedical Science Authors: Verinder Sharma, Malak Al-Farayedhi, Minakshi Doobay, Christine Baczynski Source Type: research
How Chronic Administration of Benzodiazepines Leads To Unexplained Chronic Illnesses: A Hypothesis
It is thought that an ill defined biochemical cascade may lead to protracted withdrawal symptoms subsequent to discontinuance of routine use of benzodiazepine class drugs and establish chronic illness in some patients. In this review, published findings are presented that support the novel concept that withdrawal from benzodiazepine class drugs can trigger elevated and sustained levels of a potent oxidant called peroxynitrite via potentiation of the L-type voltage-gated calcium channels, and in the later stages of withdrawal, via excessive N-methyl-D-aspartate receptor activity, as well. (Source: Medical Hypotheses)
Source: Medical Hypotheses - June 19, 2018 Category: Biomedical Science Authors: S. LaCorte Source Type: research
Plerixafor and related macrocyclic amines are potential drug candidates in treatment of malaria by “filling the flap” region of plasmepsin enzymes
Death by Plasmodium falsiparum, the leading cause of malaria, is going to remain a major obstacle among the infectious diseases. Plasmepsin aspartic proteases are key proteins in the pathogenesis of plasmodium species which break down the hemoglobin and exploit it as a source of amino acids. These enzymes are one of the favorite targeting agents for medicinal chemists to design new drugs. Plasmepsin proteins show a “flap” region in their N-terminal domain, predisposing them to a good “filler” drug with an exceptional affinity to this enzyme. (Source: Medical Hypotheses)
Source: Medical Hypotheses - June 19, 2018 Category: Biomedical Science Authors: Ardavan Abiri Source Type: research
Spinal Fluid Evacuation May Provide Temporary Relief for Patients with Unexplained Widespread Pain and Fibromyalgia
Fibromyalgia (FM) exhibits characteristics of a neurological disorder, and similarities have been identified between FM and idiopathic intracranial hypertension (IICH). When intracranial pressure rises, the drainage of excess cerebrospinal fluid (CSF) through the subarachnoid space of the cranial and spinal nerves increases. higher CSF pressure irritates nerve fibers inside nerve root sheaths and may consequently cause radicular pain, as was reported in patients with IICH. Moreover, the cut-off of 20-25 cm H20 used to define IICH may be too high, as has been suggested in patients with chronic fatigue syndrome. (Source: Medical Hypotheses)
Source: Medical Hypotheses - June 19, 2018 Category: Biomedical Science Authors: M. Hulens, R. Rasschaert, W. Dankaerts, I. Stalmans, G. Vansant, F. Bruyninckx Source Type: research
Phenylalanine hydroxylase: a biomarker of disease susceptibility in Parkinson ’s disease and Amyotrophic lateral sclerosis
The S-oxidation of S-carboxymethyl-L-cysteine has been reported previously to be a biomarker of disease susceptibility in Parkinson ’s disease and Amyotrophic lateral sclerosis. In this investigation, the original observations have been confirmed with the incidence of the poor metaboliser phenotype (no urinary recovery of S-oxide metabolites) being found to be 3.9% within healthy control population. However, 38.3% of the Parki nson’s disease subjects and 39.0% of the Amyotrophic lateral sclerosis group were phenotyped as poor metabolisers. (Source: Medical Hypotheses)
Source: Medical Hypotheses - June 19, 2018 Category: Biomedical Science Authors: Glyn B. Steventon, Stephen C. Mitchell Source Type: research
Ketogenic diet for schizophrenia: nutritional approach to antipsychotic treatment
Schizophrenia is a mental disorder that mostly appears in the second or third decade of life with no consistent appearance. The first-line pharmacological treatment are antipsychotic drugs, which mainly act by suppressing the activity of dopamine. Unfortunately many of schizophrenic patients suffer from persistent positive or negative symptoms that cannot be fully treated with available medication. With exploration on the possible causes of the disease there is evidence on dopaminergic transmission defects, there is a need to find more holistic way in treating the disease and a diet regimen could be one of them. (Source: Medical Hypotheses)
Source: Medical Hypotheses - June 19, 2018 Category: Biomedical Science Authors: Adam W łodarczyk, Mariusz S. Wiglusz, Wiesław Jerzy Cubała Source Type: research
Oral manifestations in stem cell transplantation for acute myeloid leukemia
Acute myeloid leukemia is a highly aggressive malignancy with a high morbidity rate, for which an accurate and rapid diagnostic is essential. Acute myeloid leukemia manifestations frequently include oral abnormalities. Still, there is a limited number of studies reporting the incidence of oral manifestations in acute leukemia, the prevalence of periodontal status and periodontal parameters in these patients. Our aim was to emphasize the importance of early recognition by the dental practitioners of oral cavity manifestations as signs of acute myeloid leukemia, so that prompt referral to the hematologists is being done, and...
Source: Medical Hypotheses - June 16, 2018 Category: Biomedical Science Authors: Alexandru Mester, Alexandra Irimie, Liana Oprita, Delia Dima, Bobe Petrushev, Ondine Lucaciu, Radu-Septimiu Campian, Alina Tanase Source Type: research
Evidence of an ancient (2000 years ago) goiter attributed to iodine deficiency in North America
The Adena pipe figurine was found in the 2000 year-old Adena burial mound in Ross County, Ohio, USA by William C. Mills in 1901. The pipe reportedly represents an achondroplastic dwarf male Native American. However, the clinical aspect (swelling of the neck), the environmental/cultural characteristics in this area (iodine-poor soils, absence of seafood and milk consumption, tobacco smoking), and the marked prevalence of goiter among Native American populations favor the diagnosis of a goiter associated to iodine deficiency. (Source: Medical Hypotheses)
Source: Medical Hypotheses - June 15, 2018 Category: Biomedical Science Authors: F. Bauduer, K. Barnett Tankersley Source Type: research
Bone Resorption and Bone Metastasis Risk
Breast cancer tumors have a tendency to metastasize to the bone. After development of a bone metastasis, the median survival time is 40 months. Currently, little is known about the modifiable risk factors for developing bone metastases in women diagnosed with breast cancer. One possible modifiable risk factor is increased bone resorption. Increased bone resorption is caused by an imbalance between osteoblasts and osteoclasts favoring osteoclast-driven bone resorption. Osteoclast activity results in the release of growth factors from the bony matrix that are requirement for successful breast cancer tumor cell proliferation ...
Source: Medical Hypotheses - June 15, 2018 Category: Biomedical Science Authors: Katlynn M. Mathis, Kathleen M. Sturgeon, Renate M. Winkels, Joachim Wiskemann, Mary Jane De Souza, Katherine H. Schmitz Source Type: research
