Phenylalanine hydroxylase: a biomarker of disease susceptibility in Parkinson ’s disease and Amyotrophic lateral sclerosis

The S-oxidation of S-carboxymethyl-L-cysteine has been reported previously to be a biomarker of disease susceptibility in Parkinson ’s disease and Amyotrophic lateral sclerosis. In this investigation, the original observations have been confirmed with the incidence of the poor metaboliser phenotype (no urinary recovery of S-oxide metabolites) being found to be 3.9% within healthy control population. However, 38.3% of the Parki nson’s disease subjects and 39.0% of the Amyotrophic lateral sclerosis group were phenotyped as poor metabolisers.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research