Atherosclerosis is a vascular stem cell disease caused by insulin
The present article proposes the hypothesis that when multipotent vascular stem cells are exposed to excessive insulin in a rhythmic pattern of sharply rising and falling concentrations, their differentiation is misdirected toward adipogenic and osteogenic cell lineages. This results in plaque-like accumulation of adipocytes with fat and cholesterol deposition from adipocyte debris, and osteogenic (progenitor) cells with a calcified matrix in advanced lesions. The ingrowth of capillaries and infiltration with macrophages, which upon uptake of lipids turn into foam cells, are unspecific pro-resolving reactions. (Source: Medical Hypotheses)
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: Friederike Traunm üller Source Type: research
KLF4 signalling in carcinogenesis and epigenetic regulation of hTERT
Gene expression is crucial and tightly regulated to steer the development, differentiation, proliferation and even apoptosis of a cell. Each cell and tissue type shows a unique repertoire of transcription factors. Tissue micro-environmental regulation of epigenetic signature of a gene has been documented in many cases. Epigenetic factors play a significant role in the regulation of gene expression. KLF4 is a well-known transcription factor regulating the expression of several genes including hTERT. (Source: Medical Hypotheses)
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: Suresh Singh Yadav, Rohini Ravindran Nair, Pramod Kumar Yadava Source Type: research
Differences in epidemiological features between ulcerative colitis and Crohn ’s disease: The early life-programmed versus late dysbiosis hypothesis
It is increasingly admitted that Crohn ’s disease and ulcerative colitis, the two entities of inflammatory bowel disease, are initiated and reactivated by environmental factors in genetically susceptible hosts, and result from aberrant immune response to specific intestinal microbes, in the context of altered composition of intestinal microbiota, called dysbiosis. We hypothesize that the role of the gut microbiota in Crohn’s disease pathogenesis is linked to early-life abnormal crosstalk with the host immune system under construction. (Source: Medical Hypotheses)
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: Laurent Beaugerie, Ebbe Langholz, Nynne Nyboe-Andersen, B énédicte Pigneur, Harry Sokol, ECCO Epicom Source Type: research
Out of the box: A psychedelic model to study the creative mind
Our creativity is challenged daily when facing new situations asking for novel solutions. Creativity, a multicomponent construct includes flexible divergent and rigid convergent thinking. Psychedelic drugs like psilocybin can enhance creativity and affect state of mind (mood, empathy, openness). Of note, flexible thinking is disturbed in psychopathological conditions like anxiety disorders and depression and preliminary findings have shown psychedelics to be efficacious in the treatment of those conditions. (Source: Medical Hypotheses)
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: K.P.C. Kuypers Source Type: research
Fibromyalgia as a glymphatic overload syndrome
We read with great interest the paper by Hulens et al. [1], hypothesizing that the unexplained widespread pain associated with fibromyalgia is caused by chronic postural idiopathic cerebrospinal hypertension. We admire their efforts to provide this new hypothesis and would like to comment. (Source: Medical Hypotheses)
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: Peter Wostyn, Debby Van Dam, Kurt Audenaert, Peter Paul De Deyn Source Type: research
Is the glass half empty or half full? A novel “philosophical” approach to the “mystery” of the so-called ferrule effect
The prognosis of endodontically treated teeth has traditionally been associated with the presence of the so-called ferrule effect that is generally related with the presence of a minimum of 1 –2 mm of sound tooth structure at the cervical area of parallel axial walls that totally encircle the tooth. Even though all of these factors are well desired, one should question if their absence should condemn a tooth and compel extraction as the only logical treatment plan option.For this rea son an hypothesis is being formed that associates the aforementioned factors not with the presence of the so-called ferrule effect, but r...
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: Minos Stavridakis, Yiannis Brokos, Ivo Krejci Source Type: research
Flow cytometric detection of gamma-H2AX to evaluate DNA damage by low dose diagnostic irradiation
γH2AX assay has been used for DNA damage assessment at higher doses of radiation exposure. Its expression has not been studied in cases with diagnostic low dose radiation exposure. Concerns have been raised about the after-effects of radiation in diagnostic procedures like Computed Tomography (CT) scan, Angiography etc especially when such scans are repeated within short span of time. The purpose of the present study was to assess immediate DNA damage after exposure to low level of ionizing radiation by the flow cytometric method of gamma-H2AX. (Source: Medical Hypotheses)
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: Kainat Khan, Shikha Tewari, Namrata Punit Awasthi, Surendra Prasad Mishra, Gaurav Raj Agarwal, Madhup Rastogi, Nuzhat Husain Source Type: research
KLF4 signalling in carcinogenesis and epigenetic regulation of hTERT
Gene expression is crucial and tightly regulated to steer the development, differentiation, proliferation and even apoptosis of a cell. Each cell and tissue type shows a unique repertoire of transcription factors. Tissue micro-environmental regulation of epigenetic signature of a gene has been documented in many cases. Epigenetic factors play a significant role in the regulation of gene expression. KLF4 is a well-known transcription factor regulating the expression of several genes including hTERT. (Source: Medical Hypotheses)
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: Suresh Singh Yadav, Rohini Ravindran Nair, Pramod Kumar Yadava Source Type: research
Differences in epidemiological features between ulcerative colitis and Crohn ’s disease: the early life-programmed versus late dysbiosis hypothesis.
It is increasingly admitted that Crohn ’s disease and ulcerative colitis, the two entities of inflammatory bowel disease, are initiated and reactivated by environmental factors in genetically susceptible hosts, and result from aberrant immune response to specific intestinal microbes, in the context of altered composition of intestinal microbiota, called dysbiosis. We hypothesize that the role of the gut microbiota in Crohn’s disease pathogenesis is linked to early-life abnormal crosstalk with the host immune system under construction. (Source: Medical Hypotheses)
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: Laurent Beaugerie, Ebbe Langholz, Nynne Nyboe-Andersen, B énédicte Pigneur, Harry Sokol Source Type: research
Atherosclerosis is a vascular stem cell disease caused by insulin
The present article proposes the hypothesis that when multipotent vascular stem cells are exposed to excessive insulin in a rhythmic pattern of sharply rising and falling concentrations, their differentiation is misdirected toward adipogenic and osteogenic cell lineages. This results in plaque-like accumulation of adipocytes with fat and cholesterol deposition from adipocyte debris, and osteogenic (progenitor) cells with a calcified matrix in advanced lesions. The ingrowth of capillaries and infiltration with macrophages, which upon uptake of lipids turn into foam cells, are unspecific pro-resolving reactions. (Source: Medical Hypotheses)
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: Friederike Traunm üller Source Type: research
Out of the box: a psychedelic model to study the creative mind
Our creativity is challenged daily when facing new situations asking for novel solutions. Creativity, a multicomponent construct includes flexible divergent and rigid convergent thinking. Psychedelic drugs like psilocybin can enhance creativity and affect state of mind (mood, empathy, openness). Of note, flexible thinking is disturbed in psychopathological conditions like anxiety and depression and preliminary findings have shown psychedelics to be efficacious in the treatment of those conditions. (Source: Medical Hypotheses)
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: K.P.C. Kuypers Source Type: research
Fibromyalgia as a glymphatic overload syndrome
We read with great interest the paper by Hulens et al. [1], hypothesizing that the unexplained widespread pain associated with fibromyalgia is caused by chronic postural idiopathic cerebrospinal hypertension. We admire their efforts to provide this new hypothesis and would like to comment. (Source: Medical Hypotheses)
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: Peter Wostyn, Debby Van Dam, Kurt Audenaert, Peter Paul De Deyn Source Type: research
Is the glass half empty or half full? A novel “philosophical” approach to the “mystery” of the so-called ferrule effect.
The prognosis of endodontically treated teeth has traditionally been associated with the presence of the so-called ferrule effect that is generally related with the presence of a minimum of 1 to 2 mm of sound tooth structure at the cervical area of parallel axial walls that totally encircle the tooth. Even though all of these factors are well desired, one should question if their absence should condemn a tooth and compel extraction as the only logical treatment plan option.For this reason an hypothesis is being formed that associates the aforementioned factors not with the presence of the so-called ferrule effect, but rath...
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: Minos Stavridakis, Yiannis Brokos, Ivo Krejci Source Type: research
Flow Cytometric Detection of Gamma-H2AX To Evaluate DNA Damage by Low Dose Diagnostic Irradiation
γH2AX Assay has been used for DNA damage assessment at higher doses of radiation exposure. Its expression has not been studied in cases with diagnostic low dose radiation exposure. Concerns have been raised about the after-effects of radiation in diagnostic procedures like Computed Tomography (CT) scan, Angiography etc especially when such scans are repeated within short span of time. The purpose of the present study was to assess immediate DNA damage after exposure to low level of ionizing radiation by the flow cytometric method of Gamma-H2AX. (Source: Medical Hypotheses)
Source: Medical Hypotheses - March 26, 2018 Category: Biomedical Science Authors: Kainat Khan, Shikha Tewari, Namrata Punit Awasthi, Surendra Prasad Mishra, Gaurav Raj Agarwal, Madhup Rastogi, Nuzhat Husain Source Type: research
The role of Alu-derived RNAs in Alzheimer ’s and other neurodegenerative conditions
Non-coding RNAs have emerged as essential contributors to neuroinflammation. The Alu element is the most abundant potential source of non-coding RNA in the human genome represented by over 1.1 million copies totaling ∼10% of the genome's mass. Accumulation of “Alu RNA” was observed in the brains of individuals with dementia and Creutzfeldt-Jakob disease – a degenerative brain disorder. “Alu RNAs” activate inflammatory pathways and apoptosis in the non-neural cells. In particular, the “Alu RNA” cy totoxicity is suggested as a mechanism in retinal pigment epithelium (RPE), a compartment damaged in the process...
Source: Medical Hypotheses - March 22, 2018 Category: Biomedical Science Authors: Oksana Polesskaya, Evgeniya Kananykhina, Astrid M. Roy-Engel, Olga Nazarenko, Irina Kulemzina, Ancha Baranova, Yegor Vassetsky, Max Myakishev-Rempel Source Type: research
