Differences in epidemiological features between ulcerative colitis and Crohn ’s disease: The early life-programmed versus late dysbiosis hypothesis

It is increasingly admitted that Crohn ’s disease and ulcerative colitis, the two entities of inflammatory bowel disease, are initiated and reactivated by environmental factors in genetically susceptible hosts, and result from aberrant immune response to specific intestinal microbes, in the context of altered composition of intestinal microbiota, called dysbiosis. We hypothesize that the role of the gut microbiota in Crohn’s disease pathogenesis is linked to early-life abnormal crosstalk with the host immune system under construction.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research