Kinesiophobia modulates the feedforward motor control of the affected limb in complex regional pain syndrome (CRPS): a single-case study. Revised title: Fear of movement modulates the feedforward motor control of the affected limb in complex regional pain syndrome (CRPS): a single-case study
Pain-related fear can exacerbate physical disability and pathological pain in complex regional pain syndrome (CRPS) patients. We conducted a kinematic analysis of grasping movements with a pediatric patient suffering from CRPS in an upper limb to investigate how pain-related fear affects motor control. Using a three-dimensional measurement system, we recorded the patient ’s movement while grasping three vertical bars of different diameters (thin, middle, thick) with the affected and intact hands. (Source: Medical Hypotheses)
Source: Medical Hypotheses - December 2, 2017 Category: Biomedical Science Authors: Michihiro Osumi, Masahiko Sumitani, Yuko Otake, Shu Morioka Source Type: research
The end-stage failing human myocardium – where changes in ultrastructure of human cardiac muscle cells do not appear to dictate clinical outcomes
Heart failure is the end stage of cardiovascular abnormalities. Studies have primarily focused on the functional changes of cardiomyocytes in the failing heart from different animal models with very little information in the human condition. In addition little is known about the ultrastructural changes that proceed in cardiomyocytes in route to failure. The aim of this study was to examine the ultrastructural changes in the myocardium of human with end-stage heart failure. Left ventricular myocardial tissue samples from 7 patients with end-stage heart failure were examined with transmission and scanning electron microscopy...
Source: Medical Hypotheses - December 2, 2017 Category: Biomedical Science Authors: Ivan Varga, Paulina Galfiova, Andrea Gazova, Tomas Barczi, Stefan Polak, Lubos Danisovic, Michal Hulman, Jan Kyselovic Source Type: research
The Complex Associations Between Obstructive Sleep Apnea and Auto-Immune Disorders: A Review
Obstructive sleep apnea is known to be associated with diseases such as hypertension, metabolic disorder, and cancer. A more controversial and less understood association is that of sleep apneas and the development and worsening of autoimmune and rhuematologic disorders. Through the main pathways of intermittent hypoxia and sleep deprivation, we hypothesize that obstructive sleep apnea creates a chronic inflammatory state that worsens or incites autoimmune disorders. This thorough review of the available literature highlights our current understanding of the relationship between these disease processes in order to demonstr...
Source: Medical Hypotheses - December 1, 2017 Category: Biomedical Science Authors: Mayand Vakil, Steven Park, Anna Broder Source Type: research
A Potentially Curative Fetal Intervention for Hypoplastic Left Heart Syndrome
Hypoplastic left heart syndrome (HLHS) encapsulates a spectrum of complex congenital cardiovascular malformations involving varying degrees of underdevelopment of the left-sided heart structures. However, despite improved survival rates since the introduction of staged surgical reconstruction, treatment options for HLHS remain palliative rather than curative. A major limiting factor in the development of definitive curative therapy for HLHS is an incomplete understanding of its pathogenesis.Currently, HLHS is best conceptualised by the ‘flow theory’ of cardiogenesis, which states that normal cardiac development is reli...
Source: Medical Hypotheses - December 1, 2017 Category: Biomedical Science Authors: Andrew T. Hattam Source Type: research
Carbon dioxide therapy in hypocapnic respiratory failure
Oxygen therapy, usually administered by a facemask or nasal cannulae, is the current default treatment of respiratory failure. Since respiration entails intake of oxygen and release of carbon dioxide from tissues as waste product, the notion of administering carbon dioxide in respiratory failure appears counter-intuitive. However, carbon dioxide stimulates the chemosensitive area of the medulla, known as the central respiratory chemoreceptor, which activates the respiratory groups of neurones in the brainstem and stimulates inspiration thereby initiating oxygen intake during normal breathing. (Source: Medical Hypotheses)
Source: Medical Hypotheses - November 30, 2017 Category: Biomedical Science Authors: P.O.O. Julu, M. Shah, J.A. Monro, B.K. Puri Source Type: research
