The end-stage failing human myocardium – where changes in ultrastructure of human cardiac muscle cells do not appear to dictate clinical outcomes

Heart failure is the end stage of cardiovascular abnormalities. Studies have primarily focused on the functional changes of cardiomyocytes in the failing heart from different animal models with very little information in the human condition. In addition little is known about the ultrastructural changes that proceed in cardiomyocytes in route to failure. The aim of this study was to examine the ultrastructural changes in the myocardium of human with end-stage heart failure. Left ventricular myocardial tissue samples from 7 patients with end-stage heart failure were examined with transmission and scanning electron microscopy.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research